“…Flavonoids, secondary metabolites, are widely available in the plant kingdom, both in free form and the form of glycosides, with a wide range of pharmacological [38] Derivatives of various flavonoids from the genus Rhamnus have been reported. Members of this genus have had a wide range of applications in modern medicine from ancient times to the present [39] In addition, the plants of the genus Rhamnus are known for antimicrobial, antirheumatic, hypoglycemic, anthelmintic, antipyretic, antiepileptic, and antidiabetic, in the treatment of vertigo, headache, eye diseases, and elimination of intestinal worms [19] . The main strategy to avoid or reduce QS-regulated bacterial virulence is to block the receptor by structural analogs of the QS signaling molecule.…”