Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review)

Abstract

Emerging evidence on molecular biology related to tumors, inflammation, and immunity, highlights their architectural commonality shifting cancer treatment paradigms toward more economical prevention than treatment. Statistical surveys reveal exponentially growing herbal drug supplementation in cancer worldwide as vast pre‐clinical and clinical data unravel their multi‐mechanistic pharmacology. The integrative oncological approach calls for more “holistic” principles to be amalgamated into cancer care. New cancer drug development from herbs need not be limited by the archetypal ‘RCT‐Standardization’ bottlenecks. Based on comprehensive literature scoping as per Prisma‐ScR guidelines, we herein concurrently reviewed evidence‐based research reports of selected Indian Traditional Medicine (ITM) herbs of anticancer repute in parallel with their holistic therapeutics; a rationalistic exploration of ITM's scientific genre. Their synergy effect on cancer revisited using a trans‐pharmacological approach validates ITM's seemingly simplistic health/disease equation model, showing a fresh new avenue for re‐purposing whole herbal drug complexes in cancer management. Herbal drugs as per ITM are natural matrices whose dynamics of interaction in the etiopathology of cancer are conceptually and mechanistically integrative. Lateral perspective to the same as laid out in this review holds the key to their effectual development as more tangible cancer chemopreventives/new drug targets/leads if not as new pharmacological tools.

Traditional Chinese Medicine Approaches for the Treatment of Diabetes

“…However, the current chapter will give information not only about different aspects that are utilized in TCM but also provide the latest research and review on this context. (White et al, 2018;Kalachaveedu et al, 2023).…”

Anticancer Potential of Indole Phytoalexins and Their Analogues

“…Despite advancements in treatment modalities, the quest for novel and more effective anticancer agents persists. In recent years, natural compounds have garnered considerable attention due to their diverse pharmacological activities and potential as leads for drug development [2][3][4]. Among these, indole phytoalexins have emerged as intriguing candidates for exploration due to their diverse biological activities and potential as anticancer agents.…”

Effect of Using Ground Anise Seeds with Ground Pomegranate Peels on some Productive and Physiological Traits After Parturition of Local Female Goats

“…Herbs with hypolipidemic, antiplatelet, anticancer, or immune-stimulating characteristics have attracted a lot of attention from researchers because they might be effective tools in the fight against cancer and cardiovascular disease. Antimicrobial activity is just one of their many biological activities; they also act as hypocholesterolemics and antioxidants [3][4][5][6]. They also stimulate the digestive systems of animals [7][8][9][10][11][12], leading to an increase in enzyme production and better utilization of digestive products through improved liver functions [13][14][15].…”

“…Anise is a fragrant annual herb native to a wide variety of warm climates, including Iran, India, Turkey, and Egypt. Its scientific name is Piminella anisum L. Anise has several potential medical uses, including as an antiparasitic, antibacterial, antifungal, antipyretic, and digestive aid [4,[19][20][21]. It may even have direct antiviral properties.…”