Traditional, one-pot three-component synthesis and anti-bacterial evaluations of some new pyrimidine derivatives

Mamand, Soran O.; Abdul, Dalia A.; Ayoob, Mzgin M.; Hussein, Awaz J.; Samad, Mohammed K.; Hawaiz, Farouq E.

doi:10.1016/j.inoche.2023.111875

Inorganic Chemistry Communications

2024

DOI: 10.1016/j.inoche.2023.111875

|View full text |Cite

Traditional, one-pot three-component synthesis and anti-bacterial evaluations of some new pyrimidine derivatives

Soran O. Mamand,

Dalia A. Abdul,

Mzgin M. Ayoob

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Synthesis Development and Molecular Docking Study of New Azo Chalcone Derivatives

Ibrahim,

Mohammed

2024

ARO

View full text Add to dashboard Cite

This work is divided into two main parts. The first part involves the synthesis of new azo chalcone compounds through a two-step process. Initially, azo compounds are synthesized by diazotizing 3-nitroaniline, followed by a coupling reaction with 4-hydroxyacetophenone, which has a terminal ketone group. Subsequently, the resulting product undergoes a Claisen–Schmidt condensation reaction with various aromatic aldehyde substrates to produce new α, β-unsaturated ketones, known as azo chalcone compounds. The successful synthesis of these compounds is confirmed using Fourier-transform infrared spectroscopy, ¹HNMR, and ¹³C NMR spectral analyses. The second part of this study explores the theoretical biological activity of the synthesized compounds against severe acute respiratory syndrome coronavirus 2 through molecular docking studies. The results indicate potential antiviral properties for each compound, with compounds B5 and B8 exhibiting the most promising results. These compounds achieved higher docking scores (ΔG −6.235 kcal/mol and −5.832 kcal/mol, respectively) and each formed four hydrogen bonds with the target protein.

show abstract

Synthesis Development and Molecular Docking Study of New Azo Chalcone Derivatives

Ibrahim,

Mohammed

2024

ARO

View full text Add to dashboard Cite

show abstract

Synthesis, Characterization, Antimicrobial Activity, and Molecular Docking Study of Newer Chalcone-based Triazolo Pyrimidine Compounds

Gohil,

Das,

Boruah

2024

COC

View full text Add to dashboard Cite

Abstract:: In this work, we present the synthesis of a newer series of 15 chalcone-based pyrimidine compounds 4a-o. All the compounds were characterized by elemental analysis, melting point determination, mass, FTIR, and NMR analysis. We have evaluated the antimicrobial activity of these compounds. The compounds showed good inhibition activity towards different bacterial and fungal species such as S. aureus, S. pneumonia, E. coli, P. aeruginosa, Candida albicans, Aspergillus niger, and Alternaria alternata. Compounds 4c, 4h, 4k, and 4g showed comparable activities to those of commercially available drugs. Molecular docking study showed good interaction between each of the compounds and DNA gyrase enzyme. The docking score of the compounds ranges between -8.0 to -8.9 kcal/mol. Further, the ADMET analysis indicated the potential of the compounds as a drug candidate.

show abstract

Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects

Venugopala,

Kamat

2024

Pharmaceuticals

View full text Add to dashboard Cite

Pyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not many technical skills are needed. All these factors attract chemists to focus more on pyrimidines. Apart from the synthesis of biological applications of pyrimidines, medicinal chemists have gathered to explore more pyrimidine scaffolds due to their interesting medicinal properties and easy targeting of various binding sites. This review delves into the diverse biological activities of compounds derived from pyrimidine during the year 2024. We have attempted to explore the growing significance of pyrimidine derivatives and provide a new path for designing new potent molecules.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Traditional, one-pot three-component synthesis and anti-bacterial evaluations of some new pyrimidine derivatives

Cited by 3 publications

References 43 publications

Synthesis Development and Molecular Docking Study of New Azo Chalcone Derivatives

Synthesis Development and Molecular Docking Study of New Azo Chalcone Derivatives

Synthesis, Characterization, Antimicrobial Activity, and Molecular Docking Study of Newer Chalcone-based Triazolo Pyrimidine Compounds

Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects

Contact Info

Product

Resources

About