Traditional risk factors for Helicobacter pylori infection not found among patients undergoing diagnostic upper endoscopy—Republic of Georgia, 2007–2008

Tarkhashvili, Nato; Chakvetadze, Neli; Mebonia, Nana; Chubinidze, Marina; Bakanidze, Lela; Shengelidze, Vladimer; Mirtskhulava, Merab; Chachava, Tamar; Katsitadze, Guram; Gabunia, Ucha; Kordzaia, Dimitri; Imnadze, Paata; Guarner, Jeannette; Sobel, Jeremy

doi:10.1016/j.ijid.2012.05.1031

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…However, regardless of whether 14 C‐UBT or serological assay was used, participants over 50 years exhibited a gradual decline in the H. pylori infection rate. This result was similar to reports from Linqu and Yangzhong of China [6, 14], but inconsistent with other studies which reported that old age groups were at a higher risk for infection than young ones [26]. There are two possible reasons to explain these findings.…”

Section: Discussioncontrasting

confidence: 64%

Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north‐western China

Zhang

et al. 2020

Tropical Med Int Health

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Objectives To evaluate the prevalence of Helicobacter pylori infection and risk factors and to serotype the strains in Wuwei, located in north‐western China, which has a high incidence of gastric cancer. Methods Helicobacter pylori infection was analysed in 21 291 adults by 14C‐urea breath test, and H. pylori antibody were detected in 9183 serum samples by latex immunoturbidimetric method. The correlation of H. pylori infection with demographic–economic, lifestyle factors and medical history among the participants was determined by questionnaire. The antibodies against H. pylori urease, VacA and CagA in serum were determined by dot immunobinding assay. Results The infection rate of H. pylori was 53.0%, and 90.1% of strains were type I strains. The H. pylori infection rate was higher among farmers (OR = 1.34, 95% CI: 1.19–1.50) and individuals who had a junior high school or higher education level (OR = 1.10, 95% CI: 1.06–1.15), and was lower in older individuals (OR = 0.86, 95% CI: 0.83–0.90), individuals with high income (OR = 0.93, 95% CI: 0.90–0.95), individuals with a habit of eating quickly (OR = 0.93, 95% CI: 0.87–0.99) and individuals who consumed more fruit and vegetables (OR = 0.90, 95% CI: 0.85–0.95). Individuals with history of cholecystitis/cholecystolithiasis, hypertension and asthma were negatively correlated with H. pylori infection (P < 0.05). Conclusion The prevalence of H. pylori infection is high in Wuwei. The major prevalent strain is type I strain. Age, education, occupation, household income, consumption of fruit and vegetables, and habit of eating quickly are independent risk factors for H. pylori infection, which is also associated with individuals with a history of extragastric diseases.

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Section: Discussioncontrasting

confidence: 64%

Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north‐western China

Zhang

et al. 2020

Tropical Med Int Health

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“…The virulence factors of H. pylori are important risk determinants but are not sufficient to induce the full development of severe gastroduodenal disease. The host’s genetic and sociocultural factors also contribute to the risk of pre-cancerous lesions and gastric cancer [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

The EPIYA-ABCC motif pattern in CagA of Helicobacter pyloriis associated with peptic ulcer and gastric cancer in Mexican population

et al. 2014

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BackgroundHelicobacter pylori chronic infection is associated with chronic gastritis, peptic ulcer, and gastric cancer. Cytotoxin-associated gene A (cagA)-positive H. pylori strains increase the risk of gastric pathology. The carcinogenic potential of CagA is linked to its polymorphic EPIYA motif variants. The goals of this study were to investigate the frequency of cagA-positive Helicobacter pylori in Mexican patients with gastric pathologies and to assess the association of cagA EPIYA motif patterns with peptic ulcer and gastric cancer.MethodsA total of 499 patients were studied; of these, 402 had chronic gastritis, 77 had peptic ulcer, and 20 had gastric cancer. H. pylori DNA, cagA, and the EPIYA motifs were detected in total DNA from gastric biopsies by PCR. The type and number of EPIYA segments were determined by the electrophoretic patterns. To confirm the PCR results, 20 amplicons of the cagA 3′ variable region were sequenced, and analyzed in silico, and the amino acid sequence was predicted with MEGA software, version 5. The odds ratio (OR) was calculated to determine the associations between the EPIYA motif type and gastric pathology and between the number of EPIYA-C segments and peptic ulcers and gastric cancer.ResultsH. pylori DNA was found in 287 (57.5%) of the 499 patients, and 214 (74%) of these patients were cagA-positive. The frequency of cagA-positive H. pylori was 74.6% (164/220) in chronic gastritis patients, 73.6% (39/53) in peptic ulcer patients, and 78.6% (11/14) in gastric cancer patients. The EPIYA-ABC pattern was more frequently observed in chronic gastritis patients (79.3%, 130/164), while the EPIYA-ABCC sequence was more frequently observed in peptic ulcer (64.1%, 25/39) and gastric cancer patients (54.5%, 6/11). However, the risks of peptic ulcer (OR = 7.0, 95% CI = 3.3–15.1; p < 0.001) and gastric cancer (OR = 5.9, 95% CI = 1.5–22.1) were significantly increased in individuals who harbored the EPIYA-ABCC cagA gene pattern.ConclusionscagA-positive H. pylori is highly prevalent in southern Mexico, and all CagA variants were of the western type. The cagA alleles that code for EPIYA-ABCC motif patterns are associated with peptic ulcers and gastric cancer.

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“…However, previous studies have shown ambiguous associations between H. pylori infection and age. Tarkhashvili et al showed that H. pylori infection was associated with older age, and they attributed the higher infection rate to lower socioeconomic conditions (18). A study that aimed to explore associations between H. pylori infection and metabolic syndrome also showed a higher prevalence in older age groups (19).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors for Helicobacter pylori infection in southwest China: a study of health examination participants based on 13C-urea breath test

Liu¹,

Wang²,

Zhao³

et al. 2017

Turk J Med Sci

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Background/aim: Helicobacter pylori (H. pylori) has a high prevalence in developing countries. We aimed to investigate the current prevalence of H. pylori, as well as its potential serum risk factors, in a population from southwest China. Materials and methods:This cross-sectional study included 10,912 subjects who received medical examinations at the First Affiliated Hospital of Chongqing Medical University in 2014. Data regarding physical examinations and biochemical measurements were collected, and H. pylori infection was diagnosed with a 13 C-urea breath test. Logistic regression was conducted to identify the risk factors for H. pylori infection. Results:The infection rate of H. pylori was 34.4% (3750/10,912). Older age, lower albumin levels, and higher total cholesterol, LDLcholesterol, and fasting blood sugar were significantly associated with increased incidence of H. pylori infection. Moreover, logistic regression analysis showed that older age, low albumin, and hyperglycemia were independent risk factors for H. pylori infection after adjusting for other covariables. Conclusion:The results from our study showed that H. pylori was prevalent in southwest China. Older age, low albumin levels, and hyperglycemia were significant risk factors associated with H. pylori infection.

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Traditional risk factors for Helicobacter pylori infection not found among patients undergoing diagnostic upper endoscopy—Republic of Georgia, 2007–2008

Cited by 5 publications

References 28 publications

Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north‐western China

Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north‐western China

The EPIYA-ABCC motif pattern in CagA of Helicobacter pyloriis associated with peptic ulcer and gastric cancer in Mexican population

Prevalence and risk factors for Helicobacter pylori infection in southwest China: a study of health examination participants based on 13C-urea breath test

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