Traditional <scp>C</scp>hinese medicine and cancer: History, present situation, and development

Liu, Jie; Wang, Shuo; Zhang, Ying; Fan, Huiying; Lin, Hongsheng

doi:10.1111/1759-7714.12270

Cited by 169 publications

(133 citation statements)

References 46 publications

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“…Traditional Chinese Medicine (TCM) has a long history for treating cancer in China, and to date, the Guidelines of Diagnosis and Therapy in Oncology using TCM was generated with international standards, to be consistent with modern clinical practice 10 . Poria robiniophila (Murrill) Ginns (formerly called Trametes robiniophila Murr) or Huaier is a sandy beige mushroom that grows on hard wood trees.…”

Section: Introductionmentioning

confidence: 99%

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

Chang

Shu²,

Laurence

et al. 2018

Gut

176

140

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Section: Introductionmentioning

confidence: 99%

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

Chang

Shu²,

Laurence

et al. 2018

Gut

176

140

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“…Traditional Chinese herbal medicines have long been used to treat diseases including cancer, while effective chemical components have not been clearly elucidated [1–12]. SH003 is a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag), and Trichosanthes Kirilowii Maximowicz (Tk), which is based on the principle of traditional Chinese medicine [12–16].…”

Section: Introductionmentioning

confidence: 99%

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2

et al. 2016

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Tumor angiogenesis is a key feature of cancer progression, because a tumor requires abundant oxygen and nutrition to grow. Here, we demonstrate that SH003, a mixed herbal extract containing Astragalus membranaceus (Am), Angelica gigas (Ag) and Trichosanthes Kirilowii Maximowicz (Tk), represses VEGF-induced tumor angiogenesis both in vitro and in vivo. SH003 inhibited VEGF-induced migration, invasion and tube formation in human umbilical vein endothelial cells (HUVEC) with no effect on the proliferation. SH003 reduced CD31-positive vessel numbers in tumor tissues and retarded tumor growth in our xenograft mouse tumor model, while SH003 did not affect pancreatic tumor cell viability. Consistently, SH003 inhibited VEGF-stimulated vascular permeability in ears and back skins. Moreover, SH003 inhibited VEGF-induced VEGFR2-dependent signaling by blocking VEGF binding to VEGFR2. Therefore, our data conclude that SH003 represses tumor angiogenesis by inhibiting VEGF-induced VEGFR2 activation, and suggest that SH003 may be useful for treating cancer.

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“…For improved therapeutic effect and higher quality of life, multi-target therapy should be emphasized, and the majority of TCMs including HDW exhibit advantages in this respect (27,28). HDW has been reported to be clinically effective with few side effects (5). In the present study using MTT assays, colony formation assays, CFDA-SE and annexin V/PI staining, it was established that the anticancer effect of CEHDW is primarily achieved through the inhibition of proliferation and promotion of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…TCM combined with modern treatments may improve symptoms, enhance quality of life, prevent recurrence and metastasis, and prolong patient survival. Additionally, TCM has potential advantages in patients who are not suitable candidates for radiotherapy and chemotherapy (5). TCM involves numerous chemical compounds, and is therefore considered to be multi-component and multi-target exerting therapeutic functions in a more holistic way.…”

Section: Introductionmentioning

confidence: 99%

Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways

et al. 2017

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Abstract.Hedyotis diffusa Willd (HDW) is a widely used traditional Chinese medicine in clinical therapy to treat various types of cancer, including colorectal cancer (CRC), but its effective polar fractions and functional mechanisms remain unclear. The aim of the present study was to determine the most effective extract of HDW and to investigate its effects on the regulation of CRC cell proliferation and apoptosis, as well as to investigate the underlying molecular mechanisms. The results demonstrated that the chloroform extract of HDW (CEHDW) exhibited the most anticancer ability. Furthermore, results of the MTT assay, colony formation, carboxyfluorescein diacetate succinimidyl ester assay and annexin V/propidium iodide staining suggested that CEHDW significantly inhibits proliferation and promotes apoptosis in the SW620 CRC cell line. Additionally, reverse transcription-polymerase chain reaction and western blot analysis demonstrated that CEHDW treatment downregulated the expression of Survivin, proliferating cell nuclear antigen, Cyclin D1, cyclin-dependent kinase 4 and B-cell lymphoma 2 (Bcl-2), and upregulated the expression of Bcl-2-associated X protein at the mRNA and protein levels. CEHDW also decreased the phosphorylation of protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK), which indicated that the suppression of the AKT and ERK signaling pathways may be one of the underlying molecular mechanisms by which CEHDW exhibited its anticancer effect. Thus, CEHDW may be a promising agent for anticancer therapy.

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Traditional Chinese medicine and cancer: History, present situation, and development

Cited by 169 publications

References 46 publications

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2

Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways

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