Traditional <scp>J</scp>apanese medicine, <i><scp>Y</scp>okukansan</i>, for the treatment of nocturnal enuresis in children

Ohtomo, Yoshiyuki; Umino, Daisuke; Takada, Moriatsu; Niijima, Shinichi; Fujinaga, Shuichiro; Shimizu, Toshiaki

doi:10.1111/ped.12158

Cited by 11 publications

(9 citation statements)

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“…Some clinical trials assessed the efficacy and safety of "Suoquan" (a herbal medicine) used in traditional Korean and traditional Chinese medicine for the treatment of enuresis (49). "Yokukansan" is a Japanese traditional herbal prescription that is a candidate for the second-line therapy of nocturnal enuresis (50).…”

Section: Discussionmentioning

confidence: 99%

Nocturnal Enuresis in Children and Its Herbal Remedies in Medieval Persia: A Narrative Review

2019

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Context: Nocturnal Enuresis (NE) refers to intermittent involuntary voiding during sleep in a child aged five years or more without any other urinary tract symptoms. Although pharmacological interventions are useful, the NE of most children relapses after the medication is discontinued. Persian Medicine (PM), as an complementary and alternative medicine, offers some useful herbal remedies to manage this disorder. This study aimed to introduce the most common medicinal plants used in Iranian Traditional Medicine (ITM) for the treatment of NE in children.Evidence Acquisition: In this study, we collected and classified the information about nocturnal enuresis in the old reliable Persian medical texts. Then the achieved information was compared with contemporary medical findings in credible published articles.Results: NE is a well-known disorder mentioned in PM. Lifestyle modification, in addition to herbal, animal, and mineral medicines, have been used to treat NE; however, most remedies have focused on medicinal herbs. In our investigation, 29 plants were used in ITM as the most frequently used herbs for the treatment of NE in children. These therapeutic herbs were used alone or in combination with other compounds in various forms. Most of them control NE with their anticholinergic and antispasmodic effects. Through literature review, it was found that few studies have investigated the utilization of these plants in children with enuresis. Conclusion:Despite the vast use of these herbs in PM, evidence of their effectiveness in children with enuresis is not strong, so clinical trials and pharmacological tests are required to evaluate safety and efficacy of these herbal remedies.

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Section: Discussionmentioning

confidence: 99%

Nocturnal Enuresis in Children and Its Herbal Remedies in Medieval Persia: A Narrative Review

2019

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“…A total of 157 patients were given ODM as the treatment for PMNE between May 2012 and October 2013 at the outpatient clinics of Juntendo University Nerima Hospital (Tokyo, Japan), Juntendo University Juntendo Hospital (Tokyo, Japan) and Musashimurayama Hospital (Tokyo, Japan). Fourteen of them were enrolled in our previous study, and only children 6–15 years old with enuresis without daytime LUTS were included in the study. Any child with neuropathic bladder, spinal dysraphism, anatomical abnormalities (e.g.…”

Section: Methodsmentioning

confidence: 99%

Gradual tapering of desmopressin leads to better outcome in nocturnal enuresis

Ohtomo

Umino

Takada

et al. 2015

Pediatrics International

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“…Only one previous case study of the effectiveness of YKS in nocturnal enuresis in children has been conducted. Interestingly, in a child with monosymptomatic nocturnal enuresis who did not response to desmopressin, which is the primary therapy for nocturnal enuresis, YKS with desmopressin was shown to be effective [84]. However, this case of pediatric monosymptomatic nocturnal featured no other lower urinary tract symptoms or history of bladder dysfunction or PD-like symptoms.…”

Section: Relevance Of Yks To Autonomic Dysfunctionsmentioning

confidence: 99%

Potential Application of Yokukansan as a Remedy for Parkinson’s Disease

Jang

Jung

Kim

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Parkinson's disease (PD), the second most common progressive neurodegenerative disorder, is characterized by complex motor and nonmotor symptoms. The clinical diagnosis of PD is defined by bradykinesia and other cardinal motor features, although several nonmotor symptoms are also related to disability, an impaired quality of life, and shortened life expectancy. Levodopa, which is used as a standard pharmacotherapy for PD, has limitations including a short half-life, fluctuations in efficacy, and dyskinesias with long-term use. There have been efforts to develop complementary and alternative therapies for incurable PD. Yokukansan (YKS) is a traditional herbal medicine that is widely used for treating neurosis, insomnia, and night crying in children. The clinical efficacy of YKS for treating behavioral and psychological symptoms, such as delusions, hallucinations, and impaired agitation/aggression subscale and activities of daily living scores, has mainly been investigated in the context of neurological disorders such as PD, Alzheimer's disease, and other psychiatric disorders. Furthermore, YKS has previously been found to improve clinical symptoms, such as sleep disturbances, neuropsychiatric and cognitive impairments, pain, and tardive dyskinesia. Preclinical studies have reported that the broad efficacy of YKS for various symptoms involves its regulation of neurotransmitters including GABA, serotonin, glutamate, and dopamine, as well as the expression of dynamin and glutamate transporters, and changes in glucocorticoid hormones and enzymes such as choline acetyltransferase and acetylcholinesterase. Moreover, YKS has neuroprotective effects at various cellular levels via diverse mechanisms. In this review, we focus on the clinical efficacy and neuropharmacological effects of YKS. We discuss the possible mechanisms underpinning the effects of YKS on neuropathology and suggest that the multiple actions of YKS may be beneficial as a treatment for PD. We highlight the potential that YKS may serve as a complementary and alternative strategy for the treatment of PD.

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Traditional Japanese medicine, Yokukansan, for the treatment of nocturnal enuresis in children

Abstract: Yokukansan should be a candidate for the medication of nocturnal enuresis.

Cited by 11 publications

References 20 publications

Nocturnal Enuresis in Children and Its Herbal Remedies in Medieval Persia: A Narrative Review

Nocturnal Enuresis in Children and Its Herbal Remedies in Medieval Persia: A Narrative Review

Gradual tapering of desmopressin leads to better outcome in nocturnal enuresis

Potential Application of Yokukansan as a Remedy for Parkinson’s Disease

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