Traditional Thai Medicines Inhibit &lt;i&gt;Helicobacter pylori&lt;/i&gt; In-Vitro and In-Vivo: Support for ethnomedical use

Mahady, Gail B.; Bhamarapravati, Sutatip; Adeniyi, Bolanle A.; Doyle, Brian J.; Locklear, Tracie; Slover, Christine M.; Pendland, Susan L.

doi:10.17348/era.4.0.159-166

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…Treated gerbils showed reduced acute and chronic inflammation when fed with B. rotunda 3 weeks before being challenged with H. pylori , and 6 weeks after. Therefore, flavonoid components of B. rotunda could potentially serve as potential drug candidate for inhibition of H. pylori infection [43]. …”

Section: Antimicrobial Activitiesmentioning

confidence: 99%

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

Eng-Chong

Lee

Chin-Fei

et al. 2012

Evidence-Based Complementary and Alternative Medicine

109

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Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be elucidated, enabling researchers to predict the potential bioactive compounds responsible for the medicinal properties of the plant. The vast biological activities exhibited by the compounds obtained from B. rotunda warrant further investigation through studies such as drug discovery, polypharmacology, and drug delivery using nanotechnology.

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Section: Antimicrobial Activitiesmentioning

confidence: 99%

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

Eng-Chong

Lee

Chin-Fei

et al. 2012

Evidence-Based Complementary and Alternative Medicine

109

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“…The dose was determined according to the amount of plant used traditionally in humans (170 mg/kg), and taking as reference the doses of other plant extracts or plant preparation studies that were assayed for anti- Helicobacter activity such as: Amu-ru7 a Mongolian folk medicine composed from Rhei rhizome, Hedychium spicatum, Radix auklandiae, Terminalia chebula, Cape Jasmine fruit , Piper longum and Calcite (200 and 800 mg/kg) [52], Calophyllum brasiliense in Brazil (100 and 200 mg/kg) [53], and the Thai plant Boesenbergia (100 mg/kg) [54]. …”

Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of anti-Helicobacter spp. activity of Hippocratea celastroides Kunth and its acute and sub-acute toxicity

García-Alonso¹,

Monroy-Noyola

Contreras-Arellano

et al. 2016

BMC Complement Altern Med

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Background Hippocratea celastroides Kunth, commonly known as “cancerina”, is used in Mexican Traditional Medicine for the treatment of gastric and intestinal infections, systemic and skin inflammation, injuries and gastritis. The aim of this research was to assess the anti-Helicobacter pylori activities of hydro-ethanolic root-bark extracts from Hippocratea celastroides Kunth in naturally infected dogs, after testing their acute and subacute toxicities in mice.MethodsTo determine in vivo acute toxicity, a hydro-ethanolic extract was obtained and administered orally in female and male Balb-C mice, at doses ranging from 2000 to 5000 mg/kg. For the subacute study, a hydro-ethanolic extract was given to male and female Balb-C mice at doses ranging from 200 to 2000 mg/kg body weight. The animals were observed daily over a period of 42 days for signs of toxicity. In the pre-clinical anti-Helicobacter spp. assay, 60 dogs were included. Eighteen and 19 dogs for the experimental and control groups respectively, concluded the study. The experimental treatment consisted of H. celastroides hydro-ethanolic extract and the control treatment of amoxicillin-clarithromycin-omeprazole.ResultsOral LD50 (lethal dose 50) values for hydro-ethanolic extract were indeterminable at the highest tested doses. Under the subacute administration, neither mortality nor any sign of toxicity were observed when the hydro-ethanolic extract was administered. There were no significant alterations in biochemical parameters. The prevalence of Helicobacter spp. infection in dogs was 97.1 % for the experimental group and 100 % for the control group. Effectiveness was of 33.3 and 55 % in the experimental and control group respectively. The oral administration of H. celastroides was well-tolerated and safe.ConclusionThe root-bark of H. celastroides produced no signs of toxicity, and manifested pharmacological activity that indicated the possibility of an alternative treatment for H. pylori infection. Effectiveness is still low so it is necessary to continue research.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1412-6) contains supplementary material, which is available to authorized users.

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“…Its extract exhibited larvicidal activity against the second and forth instar larvae of Anopheles stephensi, a vector of malaria in India (Saxena et al, 2000). C. viscosa is highly effective in a wide spectrum of diseases and reported to possess antidiarrhoeal (Devi et al, 2002), analgesic (Parimaladevi et al, 2003), antipyretic activity (Devi et al, 2003), psychopharmacological, anti-microbial properties including in vitro Helicobacter pylori and wound healing activity (Parimala et al, 2004a;Mahady et al, 2006;Panduraju et al, 2011), also against Escherichia coli , Proteus vulgaris and Pseudomonas aeruginosa (Sudhakar et al, 2006). In view of the reported effects of C. viscosa, the toxic potential of this plant was studied to generate information on its toxicity profile.…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity and histopathological assessment of methanol extract of Cleome viscosa (Linn.) whole plant.

Elufioye¹,

Onoja²

2015

J. Med. Plants Res.

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Cleome viscosa Linn (Cleomaceae) is a medicinal plant used widely in Nigeria for the management of various ailments. This research appraised the toxic potential of the plant with a view to validating or contesting its safety. Acute oral toxicity of the methanolic whole plant extract of Cleome viscosa was evaluated in mice using modified Lorke's method. Signs accompanying toxicity and possible death of animals were investigated for a period of two weeks to determine the median lethal dose (LD 50 ) of the extract. After two weeks observation period, all the animals in the respective dose groups 10, 100, 1000, 1600, 2900 and 5000 mg/kg were euthanized by cervical dislocation. The weight gained, absolute organ weight, and mean organ-body weight ratios (OBR) were determined and compared with values from those of the control group. The oral median lethal dose of the extract was found to be greater than 5000 mg/kg. There was a significant difference in weight gained on day 7 (P=0.052) among dose groups up to 1000 mg/Kg body weight. There was however, no significant difference in the relative organ weights between treated and control animals except for the Liver (p=0.048). Histopathological analysis showed mild congestion of the pulmonary vessels at dose 1600 mg/kg and above, mild diffuse vacuolar degeneration of hepatocytes across all tested dose as well as mild renal cortical congestion especially at high dose. The oral median lethal dose results indicate that the methanol extract of Cleome viscosa whole plant is non-toxic by oral administration at the tested doses.

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Traditional Thai Medicines Inhibit <i>Helicobacter pylori</i> In-Vitro and In-Vivo: Support for ethnomedical use

Cited by 13 publications

References 13 publications

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

Preclinical evaluation of anti-Helicobacter spp. activity of Hippocratea celastroides Kunth and its acute and sub-acute toxicity

Acute toxicity and histopathological assessment of methanol extract of Cleome viscosa (Linn.) whole plant.

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