Traditional usage and biological activity of Plectranthus madagascariensis and its varieties: A review

Lambrechts, Isa Anina; Lall, Namrita

doi:10.1016/j.jep.2020.113663

Cited by 14 publications

(16 citation statements)

References 59 publications

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“…hadiensis and var. tomentosus [12,15]. A recent text-mining study that applied the novel degrees of publication (DoP) method identified P. hadiensis as an understudied species [16].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Study and Antiglioblastoma Activity Assessment of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger var. hadiensis Stems

et al. 2022

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Glioblastoma (GB) is the most malignant form of primary astrocytoma, accounting for more than 60% of all brain tumors in adults. Nowadays, due to the development of multidrug resistance causing relapses to the current treatments and the development of severe side effects resulting in reduced survival rates, new therapeutic approaches are needed. The genus Plectranthus belongs to the Lamiaceae family and is known to be rich in abietane-type diterpenes, which possess antitumor activity. Specifically, P. hadiensis (Forssk.) Schweinf. ex Sprenger has been documented for the use against brain tumors. Therefore, the aim of this work was to perform the bioguided isolation of compounds from the acetonic extract of P. hadiensis stems and to investigate the in vitro antiglioblastoma activity of the extract and its isolated constituents. After extraction, six fractions were obtained from the acetonic extract of P. hadiensis stems. In a preliminary biological screening, the fractions V and III showed the highest antioxidant and antimicrobial activities. None of the fractions were toxic in the Artemia salina assay. We obtained different abietane-type diterpenes such as 7α-acetoxy-6β-hydroxyroyleanone (Roy) and 6β,7β-dihydroxyroyleanone (DiRoy), which was also in agreement with the HPLC-DAD profile of the extract. Furthermore, the antiproliferative activity was assessed in a glioma tumor cell line panel by the Alamar blue assay. After 48 h treatment, Roy exerted strong antiproliferative/cytotoxic effects against tumor cells with low IC50 values among the different cell lines. Finally, we synthesized a new fluorescence derivative in this study to evaluate the biodistribution of Roy. The uptake of BODIPY-7α-acetoxy-6β-hydroxyroyleanone by GB cells was associated with increased intracellular fluorescence, supporting the antiproliferative effects of Roy. In conclusion, Roy is a promising natural compound that may serve as a lead compound for further derivatization to develop future therapeutic strategies against GB.

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“…hadiensis and var. tomentosus [12,15]. A recent text-mining study that applied the novel degrees of publication (DoP) method identified P. hadiensis as an understudied species [16].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Study and Antiglioblastoma Activity Assessment of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger var. hadiensis Stems

et al. 2022

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“…The multiplicity of medicinal uses of the genus Plectranthus can be observed in the work of Lambrechts & Lall (2020) who verifying the traditional usage and biological activity of Plectranthus madagascariensis and its varieties. The authors observed that extract and essential oil have polyphenols, abietane diterpenes and abietane diterpenes with a quinone moiety as constituents and it used for antibacterial activity against tuberculosis and wound infections and has been consistent and correlates with its documented traditional usage of the plant.…”

Section: Planting Models Aimed At the Economic Exploitation Ofmentioning

confidence: 99%

Rural Science and Technology in Territories Under Conflicts on Amazon - The Case of Ipaupixuna Village/ Ciência E Tecnologia Rural Em Territórios Sob Conflitos Na Amazônia - O Caso Da Vila Ipaupixuna

Oliveira

2021

BJD

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Thinking about science and technology in rural niches in the Amazon naturally translates into an interdisciplinary act in the face of numerous socio-environmental and economic challenges. Thus, scientific knowledge more than ever, should now contribute to resistance to traditional peoples in the Amazon in the face of illegal deforestation, burning and soybean expansion over indigenous and quilombolas territories. Under this landscape of social conflicts and environmental degradation, with serious economic damage to traditional populations, it is therefore up to science and rural technology to innovate to resist, but, an innovation that transcends scientific or technological aspects and that strongly carries solidarity and entrepreneurship. A new way of doing science and technology in the middle of the forest and in the 21st century is necessary, this form, which is expressed in trinomials such as science-solidarity-entrepreneur or technologysolidarity-entrepreneur. The objective of this research was to create theoretical models of Conservation and Production Systems of certain plant species of high Use Value for indigenous families of the Ipaupixuna-Etnia Munduruku Village. The methodology used consisted in the analysis and use of data from the ethnobotanical and floristic survey of Ipaupixuna Village and consequent elaboration of a set of scientific-technologicalsolidarity models. The results were the creation of two (2) Species Conservation Centers, in situ and on the farm; two (2) production models focused on economic exploitation, such as Medicinal Forests and Etnogardens and finally 3 (three) units of processing plants aimed at the technological increase of plant extraction (Techextractivism).

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“…Plectranthus madagascariensis (Pers.) Benth., an indigenous South African plant that contains abietane diterpenes in its extracts and oils, has been traditionally used to treat various dermatological and respiratory ailments ( Lambrechts and Lall, 2021 ). Isodon herbs, which are native to Japan and used traditionally as bitter stomachic, contains ent -kaurane diterpenoids as their major phytoconstituent ( Tanaka and Ito, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Diterpenes: Recent Development From Natural Sources

et al. 2022

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Antimicrobial resistance has been posing an alarming threat to the treatment of infectious diseases over the years. Ineffectiveness of the currently available synthetic and semisynthetic antibiotics has led the researchers to discover new molecules with potent antimicrobial activities. To overcome the emerging antimicrobial resistance, new antimicrobial compounds from natural sources might be appropriate. Secondary metabolites from natural sources could be prospective candidates in the development of new antimicrobial agents with high efficacy and less side effects. Among the natural secondary metabolites, diterpenoids are of crucial importance because of their broad spectrum of antimicrobial activity, which has put it in the center of research interest in recent years. The present work is aimed at reviewing recent literature regarding different classes of natural diterpenes and diterpenoids with significant antibacterial, antifungal, antiviral, and antiprotozoal activities along with their reported structure–activity relationships. This review has been carried out with a focus on relevant literature published in the last 5 years following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 229 diterpenoids from various sources like plants, marine species, and fungi are summarized in this systematic review, including their chemical structures, classification, and significant antimicrobial activities together with their reported mechanism of action and structure–activity relationships. The outcomes herein would provide researchers with new insights to find new credible leads and to work on their synthetic and semisynthetic derivatives to develop new antimicrobial agents.

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Traditional usage and biological activity of Plectranthus madagascariensis and its varieties: A review

Cited by 14 publications

References 59 publications

Phytochemical Study and Antiglioblastoma Activity Assessment of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger var. hadiensis Stems

Phytochemical Study and Antiglioblastoma Activity Assessment of Plectranthus hadiensis (Forssk.) Schweinf. ex Sprenger var. hadiensis Stems

Rural Science and Technology in Territories Under Conflicts on Amazon - The Case of Ipaupixuna Village/ Ciência E Tecnologia Rural Em Territórios Sob Conflitos Na Amazônia - O Caso Da Vila Ipaupixuna

Antimicrobial Diterpenes: Recent Development From Natural Sources

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