Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus <i>Thymus</i>

Li, Xiao; He, Ting; Wang, Xiuhuan; Shen, Meng; Yan, Xin; Fan, Shusheng; Wang, Le; Wang, Xiaoping; Xu, Xiao; She, Gaimei

doi:10.1002/cbdv.201900254

Cited by 56 publications

(49 citation statements)

References 108 publications

(264 reference statements)

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“…Terpenes, especially monoterpenes, are the main constituents of essential oils of various plants, including the widely‐spread Lamiaceae . Oils obtained from mint, salvia, basil, lemon balm, etc., beyond holding high antioxidant activity, reveal other properties such as antibacterial, anti‐inflammatory or calming.…”

Section: Antioxidant Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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Section: Antioxidant Activity Of Common Terpenoidsmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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“…It is an aromatic and medicinal plant. So far, 928 species of the Thymus genus have been identified in Europe, North Africa, Asia, South America, and Australia [ 3 ]. Thymus EOs are mainly composed of terpenes, terpene alcohols, esters, and phenolic derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…Thymus EOs have beneficial effects on neurodegenerative, cardiovascular, cancer, and inflammatory diseases [ 9 ]; are traditionally used to treat respiratory tract problems [ 8 ]; and relieve gastrointestinal spasm and digestion [ 3 ]. Therefore, Thymus and its EO are functional and promising in medicine [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Thymus vulgaris L. Essential Oil Solid Formulation: Chemical Profile and Spasmolytic and Antimicrobial Effects

et al. 2020

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A new Thymus vulgaris L. solid essential oil (SEO) formulation composed of liquid EO linked to solid excipients has been chemically analysed and evaluated for its intestinal spasmolytic and antispastic effects in ex vivo ileum and colon of guinea pig and compared with liquid EO and excipients. Liquid EO and solid linked EO were analysed by original capillary electrochromatography coupled to diode array detection (CEC-DAD) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodologies. The main bioactive constituents are thymol and carvacrol, with minor constituents for a total of 12 selected analysed compounds. Liquid EO was the most effective in decreasing basal contractility in ileum and colon; excipients addiction permitted normal contractility pattern in solid linked EO SEO. In ileum and colon, the Thymus vulgaris L. solid formulation exerted the relaxant activity on K+-depolarized intestinal smooth muscle as well as liquid EO. The solid essential oil exhibits antimicrobial activity against different strains (Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Escherichia coli, Salmonella Thyphimurium, Candida albicans) similarly to liquid oil, with activity against pathogen, but not commensal strains (Bifidobacterium Breve, Lactobacillus Fermentum) in intestinal homeostasis. Therefore, Thymus vulgaris L. solid essential oil formulation can be proposed as a possible spasmolytic and antispastic tool in medicine.

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“…On the other hand, plants belonging to Thymus genus are described to have numerous traditional applications for several diseases, such as headache, ulcers, eczema, renal diseases, asthenia, wounds, verrucae, and diabetes [ 25 ]. T. decussatus Benth.…”

Section: Introductionmentioning

confidence: 99%

Phytotoxic and Antimicrobial Activities of Teucrium polium and Thymus decussatus Essential Oils Extracted Using Hydrodistillation and Microwave-Assisted Techniques

Saleh

Abd‐ElGawad

Gendy

et al. 2020

Plants

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Essential oils (EOs) have been described as promising eco-friendly secondary products of aromatic plants with several biological activities. The present study aimed to characterize the chemical composition and explore phytotoxic and antimicrobial activities of Teucrium polium and Thymus decussatus EOs extracted using hydrodistillation (HD) and microwave-assisted extraction (MAE) methods. Twenty-seven and twenty-eight compounds were identified from HD and MAE extracted EOs of T. polium, respectively. The oxygenated sesquiterpenes (57.68%) were characterized as the main components of the hydrodistilled EO with a prominence of 6-epi-shyobunol (33.00%), while sesquiterpene hydrocarbons (54.48%) were the main components of the MAE method, with a prominence of delta-cadinene (25.13%). Eighteen and nineteen compounds, were characterized in T. decussatus EOs extracted using HD and MAE methods, respectively, and oxygenated monoterpenes represented the main components of both EOs with carvacrol (94.40% and 75.91%, respectively) as the main compound. The EOs extracted using the MAE method were slightly more phytotoxic than those extracted using the HD method. The T. decussatus EO extracted using the MAE method showed a higher inhibitory effect than T. polium by 16-, 32-, and 24-fold, regarding seed germination, shoot, and root growth of lettuce, respectively. Moreover, EOs extracted by HD method showed a similar pattern with 16-, 28-, and 14-fold effects. Both T. decussatus EOs exhibited potent inhibitory effect against all tested bacteria with an inhibition zone of 34–39 mm and the lowest minimum inhibitory concentration (MIC) of 0.49, 0.98, and 1.95 μg/mL against Aspergillus niger, Escherichia coli, and Staphylococcus aureus, respectively. However, the EOs of T. polium showed weak antibacterial activity and no antifungal effect. Further studies are needed for the characterization of bioactive major compounds, either singular or synergistic, at field scale and to determine their modes of action and safety.

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Traditional Uses, Chemical Constituents and Biological Activities of Plants from the Genus Thymus

Cited by 56 publications

References 108 publications

Natural Monoterpenes: Much More than Only a Scent

Natural Monoterpenes: Much More than Only a Scent

Thymus vulgaris L. Essential Oil Solid Formulation: Chemical Profile and Spasmolytic and Antimicrobial Effects

Phytotoxic and Antimicrobial Activities of Teucrium polium and Thymus decussatus Essential Oils Extracted Using Hydrodistillation and Microwave-Assisted Techniques

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