Traditional Uses of Begonia Species (Begoniacae) in Nepal

Rajbhandary, Sangeeta

doi:10.3126/jnhm.v27i0.14150

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…from Bangladesh was used to treat snakebite, 16 Begonia hatacoa , Begonia megaptera , Begonia picta from Nepal has anthelmintic activity, Begonia panchtharensis to relieve stomachache and Begonia rubella used for wound healing. 17 On the other hand, Indonesia has two species of begonia that are used in traditional medicine, i.e. , Begonia baliensis with the local name Bacem kebo from Bali that was used to treat cough, 18 and Begonia medicinalis or Polohi Wasu from North Morowali, Central Sulawesi Province that was used to treat numerous diseases like cancer, tumour and asthma.…”

Section: Introductionmentioning

confidence: 99%

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

Maulana

Wahyuni

Widiyanti

et al. 2023

J. Public Health Afr.

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Background: The emergence of Coronavirus disease (COVID-19) has been declared a pandemic and made a medical emergency worldwide. Various attempts have been made, including optimizing effective treatments against the disease or developing a vaccine. Since the SARS-CoV-2 protease crystal structure has been discovered, searching for its inhibitors by in silico technique becomes possible. Objective: This study aims to virtually screen the potential of phytoconstituents from the Begonia genus as 3Cl pro-SARS-CoV- 2 inhibitors, based on its crucial role in viral replication, hence making these proteases “promising” for the anti-SARS-CoV-2 target. Methods: In silico screening was carried out by molecular docking on the web-based program DockThor and validated by a retrospective method. Predictive binding affinity (Dock Score) was used for scoring the compounds. Further molecular dynamics on Desmond was performed to assess the complex stability. Results: Virtual screening protocol was valid with the area under curve value 0.913. Molecular docking revealed only β-sitosterol-3-O-β-D-glucopyranoside with a lower docking score of - 9.712 kcal/mol than positive control of indinavir. The molecular dynamic study showed that the compound was stable for the first 30 ns simulations time with Root Mean Square Deviation <3 Å, despite minor fluctuations observed at the end of simulation times. Root Mean Square Fluctuation of catalytic sites HIS41 and CYS145 was 0.756 Å and 0.773 Å, respectively. Conclusions: This result suggests that β-sitosterol-3-O-β-D- glucopyranoside might be a prospective metabolite compound that can be developed as anti-SARS-CoV-2.

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Section: Introductionmentioning

confidence: 99%

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

Maulana

Wahyuni

Widiyanti

et al. 2023

J. Public Health Afr.

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“…While most Begonia species are known as an ornamental plants, a number of species are also used as food and traditional medicine. Several species are known to be edible, as reported by Rajbhandary (2013) that in Nepal there are 10 species of Begonia whose stems can be eaten raw or pickled. Similarly, Cao et al (2020) mentioned three species of Begonia as wild edible plants in Southwest China, namely B. augustinei, B. longifolia, and B. silletensis subsp.…”

Section: Introductionmentioning

confidence: 99%

Morphological diversity and phenetic relationship of wild and cultivated Begonia based on morphology and leaf venation

PERMATA

Susandarini

2022

Biodiversitas

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Abstract. Permata DA, Susandarini R. 2021. Morphological diversity and phenetic relationship of wild and cultivated Begonia based on morphology and leaf venation. Biodiversitas 23: 928-937. Begonia is an ornamental plant with intense cultivation and hybridization practices because of the uniqueness and beauty of its leaves. Begonia with a very large number of species is interesting to study, especially because Indonesia is one of the resource centers of this genus diversity as indicated by the increasing number of new species found every year. This study aimed to explore the morphological diversity of wild and cultivated Begonia and reveal the phenetic relationships of the species and hybrids based on morphology and leaf venation patterns. In this study, we used 19 Begonia samples belonging to five species collected from their natural habitat and 14 species and hybrids obtained from the nurseries. Morphological observations of living specimens and examination on microscopic slides of cleared leaf resulted in 28 characters which were used to determine phenetic relationships using cluster analysis. The high variability of leaf venation patterns described in this study disclosed the micromorphological diversity of Begonia which has not been widely exposed. The results of morphological observations showed high variabilities in leaf color, leaf shape, and petiole color. The results of cluster analysis and principal component analysis indicated that the grouping of species was mainly determined by the existence of trichomes on leaf surfaces and petiole, leaf venation pattern, leaf variegation, and leaf shape. The grouping of species resulting from cluster analysis can be used in the selection of potential parents to produce new Begonia hybrids through crossing experiments.

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“…Because of its large size, attractive color, large flower, and distinctive fruit, B. multangula is suitable for use as a yard ornamental. It can also be used for food and medicine (Rajbhandary 2013;Suresh et al 2016;Cao et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Genetic variability and phylogenetic relationships of Begonia multangula based on atpB-rbcL non-coding spacer of cpDNA sequences

Warseno

Efendi²,

CHASANI

et al. 2022

Biodiversitas

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Abstract. Warseno T, Efendi M, Chasani AR, Daryono BS. 2022. Genetic variability and phylogenetic relationships of Begonia multangula based on atpB-rbcL non-coding spacer of cpDNA sequences. Biodiversitas 23: 5491-5501. Begonia (Begoniaceae) belongs to Section Platycentrum-Sphenanthera Group which has a wide distribution from Sumatra to the Lesser Sunda Islands and Sulawesi. Information on B. multangula genetic variability and intraspecies relationships based on molecular characters is critical for developing appropriate strategies in conservation biology, breeding activities, and many other applied fields. The genetic variability and interspecific relationships of B. multangula in Indonesia were investigated using sequence data from the atpB-rbcL intergenic spacer (IGS) cpDNA regions. The atpB-rbcL IGS fragment was amplified using atpB-1 as the forward primer and rbcL-1 as the reversed primer. Genetic variations were found in the length of the sequence and nucleotide divergences in the atpB-rbcL IGS region. The genetic distance between 822 fixed sites ranged from 0 to 0.61%. Eighteen of the 822 sites (99.27%) analyzed were invariable, six sites (0,73%) were variable consisting of 4 singleton variable sites and two parsimony informative sites, and twelve sites were gaps. The phylogenetic relationships generated by B. multangula based on the atpB-rbcL IGS sequence analysis indicated the genetic variation and divided it into two clades. However, the clustering pattern of B. multangula specimens resulting from molecular analysis based on atpB-rbcL IGS sequences did not show the geographic clustering grouping pattern.

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Traditional Uses of Begonia Species (Begoniacae) in Nepal

Cited by 7 publications

References 13 publications

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

In silico screening of potential compounds from begonia genus as 3CL protease (3Cl pro) SARS-CoV-2 inhibitors

Morphological diversity and phenetic relationship of wild and cultivated Begonia based on morphology and leaf venation

Genetic variability and phylogenetic relationships of Begonia multangula based on atpB-rbcL non-coding spacer of cpDNA sequences

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