Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines from Rosa laevigata Michx.: A review

Abstract

Rosa laevigata Michx. is an ethnic medicine that have strong biological activities used in the traditional medicine system for the treatment of diabetes, nephropathy, myocardial damage, oxidative damage, liver damage and so on. Currently, The Chinese herb R. laevigata Michx. can be divided into two important medicines: Fructus R. laevigata and Radix R. laevigata, from which approximately 148 chemical components have been isolated, including flavonoids, lignans, polyphenols, steroids, triterpenoids, tannins as well as other components. Pharmacological studies have already confirmed that both of these herbs have antioxidant, anti-inflammatory, antiviral and anti-tumor activities, as well as renal protective, immunomodulatory, lipid-lowering, cardiovascular protective, bacteriostatic, and other pharmacological effects. Toxicological tests and quality control studies revealed the safety and nontoxicity of R. laevigata Michx. Therefore, this paper systematically summarizes the traditional uses, botanical, phytochemical, and pharmacology as well as the quality control and toxicology of Fructus and Radix, which in order to provide a comprehensive reference for its continued research.

Chemodiversity of Arctic Plant Dryas oxyodonta: LC-MS Profile and Antioxidant Activity

“…This situation mirrors the one observed with triterpenes. In D. oxyodonta , all detected triterpenes belonged to the ursane type, a common triterpenoid found in various members of the Rosaceae family [ 19 , 50 , 51 ]. Consequently, this triterpenoid type cannot serve as a distinguishing criterion for chemodiversity within the Dryas genus.…”

Structural Characterization and In Vitro Anti-Inflammatory Activity of Polysaccharides Isolated from the Fruits of Rosa laevigata

“…NMR spectroscopy played a crucial role in determining the type of glycosyl residues, substitution site, and sequence. 1 H NMR was used to interpret the conformation of the glycosidic bonds. In the 1 H NMR spectrum (Figure 4A), the signals of RLPa-2 in 1 H NMR ranged from 3 ppm to 6 ppm.…”

“…Rosa laevigata Michx, the dried mature pyriform fruit of the Rosaceae plant, is widely used as a medicinal and edible plant in China [1]. R. laevigata is recognized as a health food resource by the Chinese Ministry of Health, and served as a medicine for the spleen and for relieving diarrhea in Traditional Chinese Medicine (TCM) approximately 1000 years ago.…”

Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism

“…is a traditional Chinese herbal medicine. Numerous studies have confirmed its antioxidant, anti-inflammatory, and renoprotective effects [ 11 ]. The total flavonoids of Rosa laevigata Michx.…”