Traditional uses, phytochemistry, and pharmacology of Toxicodendron vernicifluum (Stokes) F.A. Barkley - A review

Li, Meichen; Zhang, Yunqiang; Meng, Cai-Wen; Gao, Jin-Gou; Xie, Chaojie; Liu, Jianyu; Xu, Yongnan

doi:10.1016/j.jep.2020.113476

Cited by 25 publications

(11 citation statements)

References 102 publications

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“…In the UHPLC-MS/MS analysis, fustin, fisetin, sulfuretin and butein were detected as the main compounds in RVX (Figure 1). It is well-known that RVS does not contain pyrrolizidine alkaloid compounds [50]. In contrast to our results, one study reported that water and ethanol extracts from RVS have a genotoxicity [51]; however, the reason may be the presence or absence of a bark.…”

Section: Discussioncontrasting

confidence: 99%

Genotoxicity of Water Extract from Bark-Removed Rhus verniciflua Stokes

Lee

Wang

et al. 2021

Molecules

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Rhus verniciflua Stokes (RVS) has been traditionally used as an herbal remedy to support the digestive functions in traditional Korean medicine. Additionally, the pharmacological effects of RVS, including antioxidative, antimicrobial and anticancer activities, have been well-reported. The genotoxicity of RVS, however, is elusive; thus, we evaluated the genotoxicity of RVS without bark (RVX) for safe application as a resource of functional food or a medical drug. To evaluate the genotoxicity of RVX, we used a bacterial reverse mutation test, chromosomal aberration test and comet assay, according to the “Organization for Economic Co-operation and Development” (OECD) guidelines. Briefly, for the reverse mutation test, samples (5000, 1667, 556, 185, 62 and 0 μg/plate of RVX or the positive control) were treated with a precultured strain (TA98, TA100, TA1535, TA1537 or WP2µvrA) with or without the S9 mix, in which RVX partially induced a reverse mutation in four bacterial strains. From the chromosomal aberration test and comet assay, the RVX samples (556, 185, 62, 20 and 0 μg/mL of RVX or the positive control) were treated in a Chinese hamster ovary cell line (CHO-K1 cells) in the conditions of the S9 mix absent or S9 mix present and in Chang liver cells and C2C12 myoblasts, respectively. No chromosomal aberrations in CHO-K1 or DNA damage in Chang liver cells and C2C12 myoblasts was observed. In conclusion, our results suggest the non-genotoxicity of RVX, which would be helpful as a reference for the safe application of bark-removed Rhus verniciflua Stokes as functional raw materials in the food, cosmetics or pharmaceutical fields.

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Section: Discussioncontrasting

confidence: 99%

Genotoxicity of Water Extract from Bark-Removed Rhus verniciflua Stokes

Lee

Wang

et al. 2021

Molecules

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“…In China, in addition to producing lacquer, the lacquer trees have long been used as a traditional herbal medicine for a variety of diseases, including infectious diseases, stomach disorders, blood disorders, and liver disease ( Saravanakumar et al, 2019 ). The leaves, buds, flowers, bark, roots, seeds, and lacquer sap of the lacquer tree can be used as medicine, and their extracts have strong antioxidant, anti-inflammatory, anti-rheumatic, anti-tumor, anti-viral effects ( Li et al, 2021b ). At present, there are more studies on the medicinal use of lacquer leaves, roots and bark, while few studies have been conducted on the medicinal value of lacquer oil, a lacquer product that is closely related to the local people’s health and livelihood in Nujiang.…”

Section: Discussionmentioning

confidence: 99%

Comparative Lipidomic and Metabolomic Analyses Reveal the Mystery of Lacquer Oil from Toxicodendron vernicifluum for the Treatment of “Yuezi” Disease in Nujiang, China: From Anti-Inflammation and Anti-Postpartum Depression Perspective

Liu

Cai

et al. 2022

Front. Pharmacol.

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Background: In southwest China, especially in Nujiang, lacquer oil from the drupes of Toxicodendron vernicifluum (Stokes) F. A. Barkley, including black lacquer oil (BLO) and white lacquer oil (WLO), is one of the most important edible oils for the local people. Through the field investigation, the locals believe that lacquer oil has benefits for parturient women and for the treatment of “Yuezi” disease. However, studies on bioactivities and the chemical compositions of lacquer oil are limited.Purpose: This study was designed to reveal the mystery of lacquer oil for the treatment of “Yuezi” disease by testing its anti-inflammatory and anti-postpartum depressant activities and related bioactive compounds.Methods: The anti-inflammatory effects of lacquer oil were examined by establishing a lipopolysaccharide (LPS)-induced RAW264.7 cell inflammation model and detecting the level of pro-inflammatory factors such as NO, IL-6 and TNF-α. The antidepressant effects of lacquer oil were studied by building a mouse model of postpartum depression (PPD), and the animal behavior changes of PPD model mice were assessed by open field test (OFT), forced swimming test (FST) and tail suspension test (TST). The chemical profiles of BLO and WLO were detected by lipidomic and the untargeted metabolomic research methods based on UPLC-MS/MS.Results: The results showed that BLO and WLO exerted anti-inflammatory effects by reducing the release of pro-inflammatory factors and BLO had better anti-inflammatory effects than WLO. While only BLO had anti-postpartum depressant activities, as evidenced by the significantly reduced the immobility time of the BLO-treated PPD mice in TST and FST compared to the PPD model mice. The comparative lipidomic analysis revealed that BLO contained high levels of Diacylglycerols (DAG) and Diacylglyceryl trimethylhomoserines (DGTS) but low level of ceramides (Cer), sphingomyelines (SM), phosphatidylcholines (PC) and phosphatidylethanolamines (PE) compared with WLO. Metabolomics analysis showed that there were 57 chemical markers between BLO and WLO, of which 17 potential biomarkers have been declared to possess anti-inflammatory and/or antidepressant activities.Conclusion: The findings of this study furnish a scientific support for the traditional uses of lacquer oil for the treatment of “Yuezi” disease from anti-inflammation and anti-postpartum depression perspective.

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“…Representative studies investigating lacquer extracts standardized in compounds that occur in both species are listed in Table 2. An important advantage of C. coggygria over T. vernicifluum is the absence of allergenic urushiols (Ippen 1983;Bertrand et al, 2008), which are common in the Asian species (Li et al, 2021).…”

Section: Cotinus Coggygria and Toxicodendron Vernicifluum: Common Groundmentioning

confidence: 99%

“…This flavanone induces apoptosis of CHG-5 and U87MG glioma cell lines, thus presenting anti-tumor effects. The mechanism involved is related to the downregulation of PI3K/Akt/NF-κB signaling pathway (Li et al, 2021). Eriodictyol also targets MEK/ERK signaling pathway, exhibiting antiproliferative properties in human nasopharyngeal CNE1 cancer cells.…”

Section: Sulfuretinmentioning

confidence: 99%

Integrating Ethnobotany, Phytochemistry, and Pharmacology of Cotinus coggygria and Toxicodendron vernicifluum: What Predictions can be Made for the European Smoketree?

et al. 2021

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The smoketree (Cotinus coggygria) is a historically known medicinal plant from Southeast Europe. Its ethnomedicinal use in skin and mucosal lesions is commonly accepted across countries. Other utilizations reported locally include fever reduction, cardiac diseases, hypertension, urinary diseases, cough, asthma, hemorrhoids, diabetes, numbness of arm, liver disease, and cancer. Departing from the smoketree’s traditional uses, this review summarizes investigations on the phytochemistry and bioactivity of the plant. In vitro and in vivo experiments supporting wound-healing, anti-inflammatory, antibacterial, cytotoxic, antioxidative, hepatoprotective, and antidiabetic effects are presented. Metabolites from smoketree that are responsible for the main pharmacological effects of smoketree are pointed out. Furthermore, the review performs a comparison between C. coggygria and the lacquer tree (Toxicodendron vernicifluum). The latter is a comprehensively studied species used in Asian phytotherapy, with whom the European smoketree shares a consistent pool of secondary metabolites. The comparative approach aims to open new perspectives in the research of smoketree and anticipates an optimized use of C. coggygria in therapy. It also points out the relevance of a chemosystematic approach in the field of medicinal plants research.

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Traditional uses, phytochemistry, and pharmacology of Toxicodendron vernicifluum (Stokes) F.A. Barkley - A review

Cited by 25 publications

References 102 publications

Genotoxicity of Water Extract from Bark-Removed Rhus verniciflua Stokes

Genotoxicity of Water Extract from Bark-Removed Rhus verniciflua Stokes

Comparative Lipidomic and Metabolomic Analyses Reveal the Mystery of Lacquer Oil from Toxicodendron vernicifluum for the Treatment of “Yuezi” Disease in Nujiang, China: From Anti-Inflammation and Anti-Postpartum Depression Perspective

Integrating Ethnobotany, Phytochemistry, and Pharmacology of Cotinus coggygria and Toxicodendron vernicifluum: What Predictions can be Made for the European Smoketree?

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