Traditional uses, phytochemistry, pharmacology, and pharmacokinetics of the root bark of Paeonia x suffruticosa andrews: A comprehensive review

Liu, Jincai; Li, Xiang; Bai, Huixin; Xu, Yang; Matsumoto, Jun; Yan, Rongfang; Wang, Siwang

doi:10.1016/j.jep.2023.116279

Cited by 12 publications

(7 citation statements)

References 224 publications

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“…Moutan Cortex (MC), as the main medicinal part, is the dry root bark of the peony, and is one of the most important herbs in traditional Chinese medicine [2]. MC was first published in the Shennong's Herbal Classic of Materia Medica [3] and performs a variety of medicinal functions, such as anti-inflammatory [4], antioxidant [5], anti-bacterial, anti-cancer [6], and anti-diabetes [7]. There are many components isolated from MC, mainly including phenols and phenolic glycosides, monoterpenes, and their glycosides, sterols, flavonoids, coumarins, polysaccharides, and organic acids, etc.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there have been various applications for the screening of bioactive compounds of MC [47,48], the evaluation of quality markers [49], the chemical fingerprinting of paeonol [45], and the quantitative determination of herbal medicines [50]. However, due to the fact that the identified compounds were prepared by means of an organic solvent in these reports, there were derivatives, geometric isomers, and more than a hundred compounds [5]. This is not conducive to the qualitative analysis of the bioactive components.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound-Assisted Extraction of Paeonol from Moutan Cortex: Purification and Component Identification of Extract

Meng,

Chen,

Zheng

et al. 2024

Molecules

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Moutan Cortex (MC) is a traditional Chinese medicine that contains abundant medicinal components, such as paeonol, paeoniflorin, etc. Paeonol is the main active component of MC. In this study, paeonol was extracted from MC through an ultrasound-assisted extraction process, which is based on single-factor experiments and response surface methodology (RSM). Subsequently, eight macroporous resins of different properties were used to purify paeonol from MC. The main components of the purified extract were identified by ultra-performance liquid chromatography–quadrupole–time of flight–mass spectrometry (UPLC-Q-TOF-MS/MS). The results indicate the optimal parameters are as follows: liquid-to-material ratio 21:1 mL/g, ethanol concentration 62%, ultrasonic time 31 min, ultrasonic temperature 36 °C, ultrasonic power 420 W. Under these extraction conditions, the actual yield of paeonol was 14.01 mg/g. Among the eight tested macroporous resins, HPD-300 macroporous resin was verified to possess the highest adsorption and desorption qualities. The content of paeonol increased from 6.93% (crude extract) to 41.40% (purified extract) after the HPD-300 macroporous resin treatment. A total of five major phenolic compounds and two principal monoterpene glycosides were characterized by comparison with reference compounds. These findings will make a contribution to the isolation and utilization of the active components from MC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Paeonol from Moutan Cortex: Purification and Component Identification of Extract

Meng,

Chen,

Zheng

et al. 2024

Molecules

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“…[15] MC possesses a range of pharmacological activities, including anticoagulant, anti-inflammatory, anti-tumour, and improvement in diabetes mellitus, among others. [15][16][17][18][19][20] However, MC is less used in agriculture, especially for fungicidal activity. Interestingly, our group discovered in a previous study that MC ethanol extract exhibited fungicidal activity against a wide range of plant pathogenic fungi, especially against R. solani, with 100 % inhibitory activity at a concentration of 1000 μg/mL.…”

Section: Introductionmentioning

confidence: 99%

“…Moutan cortex (MC), derived from the root bark of Paeonia suffruticosa Andrews, has been utilized in China's clinical practice for nearly 2000 years [15] . MC possesses a range of pharmacological activities, including anticoagulant, anti–inflammatory, anti–tumour, and improvement in diabetes mellitus, among others [15–20] . However, MC is less used in agriculture, especially for fungicidal activity.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activity Against Rhizoctonia Solani and Chemical Composition of Extract from Moutan Cortex

Zhao,

Wang,

Han

et al. 2024

Chemistry & Biodiversity

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Rice sheath blight (RSB), caused by Rhizoctonia solani, is a significant disease of rice. The negative effects of chemical fungicides have created an urgent need for low‐toxicity botanical fungicides. Our previous research revealed that the ethanol crude extract of Moutan Cortex (MC) exhibited superior antifungal activity against R. solani at 1000 μg/mL, resulting in 100% inhibition rate. And the antifungal properties were mainly found in the petroleum ether extract. However, the active ingredients of the extract are still unclear. In this study, gas chromatography‐mass spectrometry (GC‐MS) was utilised for the analysis of its chemical components. The mycelium growth rate method was utilized to detect the antifungal activity. The findings indicated that paeonol constituted the primary active component, with a content of more than 96%. Meanwhile, paeonol was the most important antifungal active ingredient, the antifungal activity of paeonol (EC50 = 44.83 μg/mL) was much higher than that of β‐sitosterol and ethyl propionate against R. solani. Observation under an optical microscope revealed that paeonol resulted in abnormal mycelial morphology. This study provided theoretical support for identifying monomer antifungal compounds and developing biological fungicides for R. solani.

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“…We focused on natural plant components to explore new effective drugs 6 and found several monomeric compounds from peony bark, which have significant effects on antidiabetic and antioxidant stress. 7 We examined the effects of these compounds on the GC‐1 cell model treated with high glucose through a drug screen (Figure S4A ), which showed that only paeonol significantly increased SIRT3 expression, especially at the concentration of 10 μM (Figures 2A–D and S4B–C ). In addition, cell proliferation and viability were inhibited at higher concentrations of paeonol (Figure S4D ).…”

mentioning

confidence: 99%

Paeonol could alleviate diabetes‐related spermatogenic dysfunction via SIRT3‐dependent redox rebalancing

Liu,

Gao,

Shi

et al. 2024

Clinical & Translational Med

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Traditional uses, phytochemistry, pharmacology, and pharmacokinetics of the root bark of Paeonia x suffruticosa andrews: A comprehensive review

Cited by 12 publications

References 224 publications

Ultrasound-Assisted Extraction of Paeonol from Moutan Cortex: Purification and Component Identification of Extract

Ultrasound-Assisted Extraction of Paeonol from Moutan Cortex: Purification and Component Identification of Extract

Inhibitory Activity Against Rhizoctonia Solani and Chemical Composition of Extract from Moutan Cortex

Paeonol could alleviate diabetes‐related spermatogenic dysfunction via SIRT3‐dependent redox rebalancing

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