Background: Some studies claim that the presence of venous ulcers (VU) negatively impacts the quality of life (QOL) of people affected and it is a major public health problem. Healthcare of these people are complex and requires planning and involvement of the multidisciplinary team that knows the profile and demands of this population.Objective: To identify associations between socioeconomic, clinical and health aspects and quality of life (QOL) of people with venous ulcers (VU), through the Charing Cross Venous Ulcer (CCVUQ).Methods: This is a cross-sectional study, conducted in mix and family health units in Natal (42 units), Rio Grande do Norte, Brazil (N=101). Were applied two instruments: a structured form on sociodemographic, clinical, and health, and the translated and validated CCVUQ in Brazil. A descriptive statistics and Mann-Whitney test, p-value <0.05 was used for analysis.Results: There was statistically significant association and indicative of worse QOL between total score with the place of origin of the north zone and pain presence; an emotional state with age until 59 years old and venous ulcer time less or equal to one year; aesthetics with age until 59 years old.Conclusion: These results demonstrate that age, origin, presence of pain, injury time and sleep interfere with the person´s QOL with VU. The research of sociodemographic, clinical and health factors is important to planning multidisciplinary actions because they can influence the person's QOL with VU.