“…HaploView 4.2 was used to screen the candidate SNPs through a r 2 critical value of 0.8, as well as a minor allele frequency (MAF) larger than 0.05. Twenty-four SNPs from 19 genes were identified and included: one SNP (rs231775) of CTLA-4, 10 one SNP (rs2227981) of PDCD1, 11 one SNP (rs7574865) of STAT4, 12 one SNP (rs763780) of IL-17F, 13 one SNP (rs4754) of OPN, 14 one SNP (rs9494885) of TNFAIP3, three SNPs (rs310230, rs310236, rs310241) of JAK1, 16 one SNP (rs2301436) of FGFR1OP, 17 one SNP (rs755622) of MIF, 18 two SNPs (rs12569232, rs6540679) of TRAF5, 19 one SNP (rs13210247) of TRAF3IP2, 20 one SNP (rs17728338) of TNIP1, 20 one SNP (rs2488457) of PTPN22, 21 one SNP (rs76481776) of miR-182, 22 one SNP (rs3212227) of IL-12B, 23 two SNPs (rs442309, rs224058) of ADO-ZNF365-EGR2, 24 two SNPs (rs78377598, rs117633859) of IL23R-C1orf141, 24 one SNP (rs6498169) of CLEC16A, 25 and one SNP (rs4703863) of AGT10 (Table 1). 26 HLA typing was not performed in our SO patients.…”