Local roads have numerous blind spots caused by complex geometry, obstacles, and narrow width. Thus, conventional proactive countermeasures, such as passive traffic signs and convex mirrors, have not always been effective in preventing local road collisions. In this paper, we present a novel proactive two-step approach for traffic safety on local roads, comprised of detection of pedestrian-to-vehicle and vehicle-to-vehicle collision risks and warning systems. First, using video surveillance and radars to eliminate blind spots, the system detects road objects, predicts their trajectories and reachable areas, and identifies a potential risk situation. Second, it provides road users such as vehicles and pedestrians with warnings through LED variable message signs, which allows them to react effectively in risky situations. We have applied the system to two local road sites in South Korea, including a university campus in Seoul City and an apartment complex in Daejeon City. The detecting system has been validated using a confusion matrix. We have assessed the warning effect through a before-and-after study and found that the proposed system contributed to the improvement of traffic safety at the case study site in that traffic conflicts decreased by 55–62%.