Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children

Mann, Jason R.; Lutzker, Liza; Holm, Stephanie M.; Margolis, Helene G.; Neophytou, Andreas M.; Eisen, Ellen A.; Costello, Sadie; Tyner, Tim; Holland, Nina; Tindula, Gwen; Prunicki, Mary; Nadeau, Kari; Noth, Elizabeth M.; Lurmann, Fred; Hammond, S. Katharine; Balmes, John R.

doi:10.1016/j.envres.2021.110870

Cited by 33 publications

(30 citation statements)

References 55 publications

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“…Statistically non-significant associations were also found between lag day 1 PM 2.5 with both SBP and DBP among elders with no anti-hypertensive medication use 13 [22]; similar results were found for PM 2.5 exposures immediately and 24-h after a 2 hr walk in close proximity to traffic for both SBP an DBP among healthy adults [23]. In children, statistically non-significant associations were found between lag day 0 (i.e., same day) exposures to PM in three size fractions and SBP [24]; also statistically non-significant associations were found between lag day 1 exposures to PM 2.5 as well as NO 2 and both SBP and DBP in children [26]. Statistically significant negative associations were also found between lag day 1-3 exposures to PM 2.5 with SBP and DBP among young adults [25].…”

Section: Discussionmentioning

confidence: 96%

Effects of short-term particulate air pollution and nitrogen dioxide on blood pressure in older women: Longitudinal data from the Women’s Health Initiative

Wen

Liao

Wellenius

et al. 2021

Preprint

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BackgroundShort-term variations in particulate matter (PM) and traffic-related air pollutants (e.g., nitrogen dioxide, NO2) have been associated with daily mortality and cardiovascular health outcomes in previous studies. We aimed to evaluate whether short-term changes in PM in three size fractions (PM2.5 , PM2.5-10 , and PM10) and NO2 were associated with systolic and diastolic arterial blood pressure (SBP and DBP, respectively) in the Women’s Health Initiative Observational Study (OS) and Clinical Trials (CT). MethodsWe used linear mixed-effect models to estimate the association between short-term air pollution concentrations and repeated measures of arterial blood pressure. ResultsWe found statistically significant positive associations between short-term measures (lag days 3-5) of PM2.5 as well as NO2 for both SBP and DBP in fully adjusted models when not controlling for calendar time. Also, in only the CT, PM10 and PM2.5-10 were associated with DBP but not SBP. In fully adjusted models controlling for calendar time, associations with PM2.5-10 and NO2 remained statistically significant for DBP (except for PM2.5-10 in the OS). Specifically, in the CT group, each IQR increase in lag 3-5 NO2 exposure (9.88 ppb) was associated with a 0.13 mm Hg increase in DBP. Also, each IQR increase in lag 3-5 PM2.5-10 exposure (8.46 µg m -3) was associated with a 0.05 mm Hg increase in DBP. Effect modification was found for body mass index (BMI), socioeconomic position (SEP), diabetes, dietary sodium intake, combined fruit and vegetable consumption, and long-term PM2.5 for PM2.5 , PM10 , and NO2 . Shorter lag periods (lag 0 through lag 2) typically exhibited lesser and, especially for SBP, sometimes negative associations. In two-pollutant models of exposures lagged over 3-5 days, NO2 associations with DBP were stronger (0.20 mm Hg per IQR), but those for PM2.5-10 were attenuated to null, as compared to single-pollutant models. ConclusionsOur findings are consistent with short-term (lag days 3-5) PM2.5-10 and NO2 levels as risk factors for acute cardiovascular outcomes and cardiovascular disease, though two-pollutant model results suggest NO2 is more likely responsible for the observed effects.

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Section: Discussionmentioning

confidence: 96%

Effects of short-term particulate air pollution and nitrogen dioxide on blood pressure in older women: Longitudinal data from the Women’s Health Initiative

Wen

Liao

Wellenius

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

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“…As a by-product of the incomplete combustion of fossil fuels, BC is among the prevalent ambient particles in the world. Exposure to traffic-related BC has a well-documented association with numerous adverse health outcomes, and the association of BC with increased systolic BP is among the most extensively studied [51][52][53]. Research reported that the emission in Manila is dominated by ultrafine particles comprising about 90% of the total ambient air pollution.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers’ Health Study

Regencia

Dalmacion

Ligsay

et al. 2021

IJERPH

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Exposure to traffic-related air pollution is linked with acute alterations in blood pressure (BP). We examined the cumulative short-term effect of black carbon (BC) exposure on systolic (SBP) and diastolic (DBP) BP and assessed effect modification by participant characteristics. SBP and DBP were repeatedly measured on 152 traffic enforcers. Using a linear mixed-effects model with random intercepts, quadratic (QCDL) and cubic (CCDL) constrained distributed lag models were fitted to estimate the cumulative effect of BC concentration on SBP and DBP during the 10 hours (daily exposure) and 7 days (weekly exposure) before the BP measurement. Ambient BC was related to increased BP with QCDL models. An interquartile range change in BC cumulative during the 7 days before the BP measurement was associated with increased BP (1.2% change in mean SBP, 95% confidence interval (CI), 0.1 to 2.3; and 0.5% change in mean DBP, 95% CI, −0.8 to 1.7). Moreover, the association between the 10-h cumulative BC exposure and SBP was stronger for female (4.0% change, 95% CI: 2.1–5.9) versus male and for obese (2.9% change, 95% CI: 1.0–4.8) vs. non-obese traffic enforcers. Short-term cumulative exposure to ambient traffic-related BC could bring about cardiovascular diseases through mechanisms involving increased BP.

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“…As a by-product of the incomplete combustion of fossil fuels, BC is among the prevalent ambient particles in the world. Exposure to traffic-related BC has a well-documented association with numerous adverse health outcomes, and the association of BC with increased systemic BP is among the most extensively studied [36][37][38]. Research reported that the emission in Manila is dominated by ultrafine particles comprising about 90% of the total ambient air pollution.…”

Section: Discussionmentioning

confidence: 99%

Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers’ Health Study

Regencia

Dalmacion

Ligsay

et al. 2021

Preprint

View full text Add to dashboard Cite

Exposure to traffic-related air pollution is linked with acute alterations in blood pressure (BP). We examined the cumulative short-term effect of black carbon (BC) exposure on systolic (SBP) and diastolic (DBP) BP and assessed effect modification by participant characteristics. SBP and DBP were repeatedly measured on 152 traffic enforcers. Using a linear mixed-effects model with random intercepts, quadratic (QCDL) and cubic (CCDL) constrained distributed lag models were fitted to estimate the cumulative effect of BC concentration on SBP and DBP during the 10-hours (daily exposure) and 7-days (weekly exposure) before the BP measurement. Ambient BC was related to increased BP with QCDL models. An interquartile range change in BC cumulative during the 7-days before the BP measurement was associated with increased BP [1.2% change in mean SBP, 95% confidence interval (CI), 0.1 to 2.3; and 0.5% change in mean DBP, 95% CI, –0.8 to 1.7]. Moreover, the association between the 10-hours cumulative BC exposure and SBP was stronger for females (4.0% change, 95% CI: 2.1–5.9) versus males, and for obese (2.9% change, 95% CI: 1.0–4.8) vs. non-obese traffic enforcers. Short-term cumulative exposure to ambient traffic-related BC could bring about cardiovascular diseases through mechanisms involving increased BP.

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Traffic-related air pollution is associated with glucose dysregulation, blood pressure, and oxidative stress in children

Cited by 33 publications

References 55 publications

Effects of short-term particulate air pollution and nitrogen dioxide on blood pressure in older women: Longitudinal data from the Women’s Health Initiative

Effects of short-term particulate air pollution and nitrogen dioxide on blood pressure in older women: Longitudinal data from the Women’s Health Initiative

Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers’ Health Study

Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers’ Health Study

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