Tragacanth Solutions I.

Levy, Gerhard; Schwarz, T.W.

doi:10.1002/jps.3030470620

Cited by 20 publications

(4 citation statements)

References 3 publications

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“…In addition it has been claimed that certain additives such as PEG 400, propylene glycol, and ethanol caused hydration and increased the gel point of Methocel solutions because they are relatively good solvents of the polymer. 26 This mechanism may explain the influence of PEG on drug release from matrices containing HPMC; i.e., the incorporation of PEG to matrices containing HPMC may increase the hydration of the polymer and therefore enhance the erosion rate of the tablet and the release rate of the drug.…”

Section: Resultsmentioning

confidence: 99%

Modeling of Drug Release from Erodible Tablets

Katzhendler

Hoffman

Goldberger

et al. 1997

Journal of Pharmaceutical Sciences

134

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A general mathematical model was developed to describe drug release from erodible tablets undergoing surface erosion. The model (which is based on the Hopfenberg equation) takes into account the three dimensions of a tablet dosage form. The model enables the characterization of the release kinetics by one or two erosion rate constants depending on the hydrodynamic conditions of the system. The model can be used to compare the release rates of the drug within different batches produced under different conditions. The model was utilized to evaluate some factors affecting the release rate from erodible tablets consisting of hydroxypropyl methylcellulose and amoxicillin. The release data of amoxicillin measured from the whole tablet followed the equation developed. Amoxicillin release data measured from the planar surface of the tablet appeared to follow zero-order kinetics as predicted by theory for drug release from an erodible device maintaining constant surface area with time.

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Section: Resultsmentioning

confidence: 99%

Modeling of Drug Release from Erodible Tablets

Katzhendler

Hoffman

Goldberger

et al. 1997

Journal of Pharmaceutical Sciences

134

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“…It has been used for many years as a stabilizer, thickener, emulsifier, and suspending agent in the food, pharmaceutical, cosmetic, textile, and leather industries as well as in technical applications based on its high viscosity at low concentration, good suspending action, unusually high stability to heat and acidity, and effective emulsifying properties. It is also pourable, has a creamy mouthfeel, good flavourrelease properties and a very long shelf life (Levy and Schwarz, 1958). Tragacanth gum is used in the food industry in salad dressings, condiments, sauces, bakery emulsions, oil and flavor emulsions, fillings and toppings, confectionery, soft drinks, jellies, desserts, ice creams, flavors, and spices .…”

Section: Overview Of Tragacanth Gum As a Natural Polysaccharidementioning

confidence: 99%

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Abdi,

Jain,

Patil

et al. 2024

Front. Mater.

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Natural polymers have many uses, and Tragacanth gum is just one of them. Many people are interested in natural gums because of their many attractive characteristics, such as being ‘green’ bio-based renewable materials, being easily accessible, inexpensive, and structurally diverse. One class of naturally occurring polysaccharides is called gum because of its tendency to create a gel or a thick solution. Among the many plant-based raw materials, these polysaccharide gums are abundant. Hydrogels, which are three-dimensional polymeric webs that can imitate live tissues, have demonstrated remarkable potential as adjustable biomaterials in numerous regenerative techniques due to their high water or biological exudate absorption capacities. Natural polysaccharides, often known as gums, are present in many different types of trees and possess many desirable properties, such as being renewable, biocompatible, biodegradable, non-toxic, and amenable to chemical modification. Many people are curious about certain parts of the food, water, energy, biotech, environmental, and healthcare sectors as of now. Gum, a type of very important and unique food ingredient, has many vital uses in the food business. Cosmetics, coating, photosensitive resin, fertilizer, casting, pharmaceuticals, and tobacco are just a few of the non-food businesses that make use of their strong water-affinity and structural plasticity. There are a lot of benefits to hydrogels made from natural gums as opposed to those made from synthetic sources. Synthesis hydrogel polymers have been the center of interest among these non-food applications because of their extensive use in the pharmaceutical and medical fields. The Tragacanth gum hydrogels used for medication delivery and tissue engineering have been the focus of this study. We also paid close attention to drug delivery, physical-chemical properties, and the extraction of Tragacanth gum. Our research has a wide range of biomedical applications, including tissue engineering for bone, skin, fixation of bone, periodontal, and cartilage. Possible futures based on hydrogels made of Tragacanth gum were likewise our primary focus.

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“…The gelation temperature is reduced to a more suitable level (i.e. to below body temperature) by the addition of metal salts, citrate, sugars like sucrose, fructose, sorbitol and glycerol [16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Methyl Cellulose based in situ Hydrogel for Controlled Drug Delivery and Tissue Engineering Application

DEWAN

2023

ajc

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Methyl cellulose is an attractive smart biomaterial for its thermoreversible gelation nature. When subjected to temperature stimuli, an aqueous solution containing methyl cellulose at a critical concentration exhibits the ability to form stable physically cross-linked hydrogels. These hydrogels alter the physico-chemical and mechanical properties of the methyl cellulose. This thermo-responsive nature become quite appealing when the physiological temperature functions as a trigger to regulate the thermogelation of methyl cellulose. Regarding this, exciting inventions have been explored in the drug delivery and tissue engineering field which make methyl cellulose an attractive and versatile biomaterial. In this review, we have covered traditional and advanced applications of methyl cellulose as thermoreversible in situ gelling system. Three main types of applications are presented: (i) in situ gelling system for controlled drug delivery; (ii) fabrication of injectable scaffolds and cell sheet for tissue engineering application; and finally (iii) developing methyl cellulose based bioink for 3D bioprinting by applying in situ thermogelation property of methyl cellulose.

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Tragacanth Solutions I.

Cited by 20 publications

References 3 publications

Modeling of Drug Release from Erodible Tablets

Modeling of Drug Release from Erodible Tablets

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Methyl Cellulose based in situ Hydrogel for Controlled Drug Delivery and Tissue Engineering Application

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