2023
DOI: 10.3390/ijms242316596
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TRAIL-Sensitizing Effects of Flavonoids in Cancer

Anderson Luiz-Ferreira,
Teresa Pacifico,
Álefe Cardoso Cruz
et al.

Abstract: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) represents a promising anticancer agent, as it selectively induces apoptosis in transformed cells without altering the cellular machinery of healthy cells. Unfortunately, the presence of TRAIL resistance mechanisms in a variety of cancer types represents a major hurdle, thus limiting the use of TRAIL as a single agent. Accumulating studies have shown that TRAIL-mediated apoptosis can be facilitated in resistant tumors by combined treatment with an… Show more

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Cited by 6 publications
(2 citation statements)
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References 114 publications
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“…This study was the first to link EIF4G1 to inflammation. TNFSF10, a small molecule drug that selectively induces apoptosis, is not as hepatotoxic as traditional chemotherapeutic agents; however, some tumor cells are not sensitive to TNFSF10 (Law et al, 2022;Luiz-Ferreira et al, 2023;Pimentel et al, 2023). Herein, we found that regulating the level of EIF4G1 can affect the sensitivity of tumor cells to TNFSF10 by altering the expression of TNFSF10 receptors, which has good clinical prospects.…”
Section: Discussionmentioning
confidence: 86%
“…This study was the first to link EIF4G1 to inflammation. TNFSF10, a small molecule drug that selectively induces apoptosis, is not as hepatotoxic as traditional chemotherapeutic agents; however, some tumor cells are not sensitive to TNFSF10 (Law et al, 2022;Luiz-Ferreira et al, 2023;Pimentel et al, 2023). Herein, we found that regulating the level of EIF4G1 can affect the sensitivity of tumor cells to TNFSF10 by altering the expression of TNFSF10 receptors, which has good clinical prospects.…”
Section: Discussionmentioning
confidence: 86%
“…On the other hand, these flavonoids have been extensively studied for their ability to induce cytotoxicity in various cancer cell lines [ 61 ]. Quercetin, for example, has been shown to inhibit the proliferation of cancer cells and induce apoptosis [ 61 ]. Kaempferol exhibits similar effects, along with potential anti-metastatic properties [ 62 ].…”
Section: Discussionmentioning
confidence: 99%