“…7 The level of skill and autonomy of the practitioner administering the sedation has not been assessed as a causative factor of failure, although in many protocols, if a nurse alone is administering sedation without further backup, both the doses of drugs and the use of drug combinations may be limited. 19,21 These limitations are justified as even triclofos sodium used alone can cause respiratory depression in sufficient dose and more so when combined with other drugs. 17,22,23 The protocol suggested in the present study addresses these issues as it provides both a rigid set of rules for the administration of sedation by a nurse and the flexibility of an anesthesiologist ''on call'' who is able to escalate sedation both in terms of drugs and doses until adequate conditions are achieved.…”