Training at non‐damaging intensities facilitates recovery from muscle atrophy

Itoh, Yuya; Murakami, Taro; Mori, Toshio; Agata, Nobuhide; Kimura, N.; Inoue-Miyazu, Masumi; Hayakawa, Kazuhide; Hirano, Takayuki; Sokabe, Masahiro; Kawakami, Keisuke

doi:10.1002/mus.25218

Cited by 11 publications

(8 citation statements)

References 50 publications

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“…Later, these same authors [ 58 ] studied the relationship between resistance training (RT) and the recovery of atrophied muscle linked to the number of myonuclei. These authors found that 14 days of tail suspension are sufficient to induce atrophy in mice, and they then investigated different intensities of maximal isometric contraction (MC) (10, 40, 60, and 90% of MC) for the period of seven days of RT.…”

Section: Discussionmentioning

confidence: 99%

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Vargas-Mendoza

Ángeles-Valencia

Madrigal-Santillán

et al. 2020

IJMS

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(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.

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Section: Discussionmentioning

confidence: 99%

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Vargas-Mendoza

Ángeles-Valencia

Madrigal-Santillán

et al. 2020

IJMS

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“…A custom-made mouse ankle joint motor function analysis system (Bio Research Center, Nagoya, Japan) was used as previously described ( Itoh et al, 2017 ). Briefly, the mice were anesthetized with isoflurane inhalation, and the plantar was attached to the pressure sensor.…”

Section: Methodsmentioning

confidence: 99%

Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice

Harada

Goto

Kato

et al. 2021

Front. Cell Dev. Biol.

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Collagen VI is distributed in the interstitium and is secreted mainly by mesenchymal stromal cells (MSCs) in skeletal muscle. Mutations in COL6A1-3 genes cause a spectrum of COL6-related myopathies. In this study, we performed a systemic transplantation study of human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) into neonatal immunodeficient COL6-related myopathy model (Col6a1KO/NSG) mice to validate the therapeutic potential. Engraftment of the donor cells and the resulting rescued collagen VI were observed at the quadriceps and diaphragm after intraperitoneal iMSC transplantation. Transplanted mice showed improvement in pathophysiological characteristics compared with untreated Col6a1KO/NSG mice. In detail, higher muscle regeneration in the transplanted mice resulted in increased muscle weight and enlarged myofibers. Eight-week-old mice showed increased muscle force and performed better in the grip and rotarod tests. Overall, these findings support the concept that systemic iMSC transplantation can be a therapeutic option for COL6-related myopathies.

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“…Disuse muscle atrophy is caused by the inactivity of the skeletal muscle, such as during prolonged bed rest. There are different in vivo models to induce skeletal muscle atrophy, including denervation, 1,2 cast immobilization, 3,4 and tail suspension (TS) 5‐9 . Denervation is unsuitable as a clinical model of muscle atrophy because it is difficult to recover from progressive atrophy.…”

Section: Introductionmentioning

confidence: 99%

“…The immobilization model is not suitable for evaluating the morphological changes of lymphatic capillaries due to inflammatory reactions caused by abrasion on the skin. The TS model has been widely used to obtain basic data on simulated weightlessness, 10 as well as to verify the effects of reloading 8 and resistance training 9 in recovery from muscle atrophy. Recently, it has been reported that the decreased myofiber cross‐sectional area (CSA) of the soleus muscle in mice subjected to 2 weeks of TS returned to control levels after 3 days of reloading 8 .…”

Section: Introductionmentioning

confidence: 99%

Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading

Kawashima

Itoh

et al. 2021

Muscle and Nerve

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Introduction/Aims Lymphatic vessels are responsible for the removal of metabolic waste from body tissues. They also play a crucial role in skeletal muscle functioning thorough their high‐energy metabolism. In this study we investigated whether disuse muscle atrophy induced by hindlimb unloading is associated with an alteration in the number of lymphatic vessels and differential expression of lymphangiogenic factors in the soleus muscle. Methods Male C57BL/6 mice were subjected to tail suspension (TS) for 2 or 4 weeks to induce soleus muscle atrophy. After TS, lymphatic and blood capillaries in the soleus muscle were visualized and counted by double staining with LYVE‐1 and CD31. The protein and mRNA levels of vascular endothelial growth factor (VEGF)‐C, VEGF‐D, and vascular endothelial growth factor receptor‐3 were measured by Western blotting and real‐time reverse transcript polymerase chain reaction, respectively. Results TS for 2 weeks resulted in a significant decrease in the number of blood capillaries compared with controls. However, there was no significant change in the number of lymphatic capillaries. By contrast, TS for 4 weeks resulted in a significant decrease in the number of lymphatic and blood capillaries. We observed a significant decrease in the mRNA levels of VEGF‐C and VEGF‐D in mice subjected to TS for 4 weeks. Discussion The decrease of intramuscular lymphatic vessels may a crucial role in the process of muscle atrophy.

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Training at non‐damaging intensities facilitates recovery from muscle atrophy

Cited by 11 publications

References 50 publications

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise Training

Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves Histological Phenotype and Function of Col6-Deficient Model Mice

Morphological and biochemical changes of lymphatic vessels in the soleus muscle of mice after hindlimb unloading

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