Training-Induced Neuroplasticity in Children with Developmental Coordination Disorder

Izadi‐Najafabadi, Sara; Gill, Kamaldeep; Zwicker, Jill G.

doi:10.1007/s40474-020-00191-0

Cited by 14 publications

(29 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…especially in the left hemisphere lateralized for motor control (Guye et al, 2003). However, our resting state results did not show such increased functional connectivity (Izadi-Najafabadi et al, 2020). This discrepancy between our structural and functional results might have different explanations.…”

Section: Motor Performancecontrasting

confidence: 84%

“…We did not find any relationship between motor performance and microstructural changes while we had previously reported a relationship between improved motor performance and functional connectivity of the cerebellar lobule I-IV and the DMN related to automatization (Izadi-Najafabadi et al, 2020). Evidence suggests that the brain-behavior relationship is explained differently when considering brain function vs. brain structure.…”

Section: Motor Performancecontrasting

confidence: 73%

“…Moreover, children with DCD + ADHD have shown unique brain structure (Langevin et al, 2014(Langevin et al, , 2015 and function (McLeod et al, 2014(McLeod et al, , 2016Thornton et al, 2018) compared to children with DCD. Compensatory attentional control by the posterior cingulate cortex and the cerebellum has been proposed as the neural mechanism of motor coordination in children with DCD + ADHD (Yeh et al, 2012); however, our resting state (Izadi-Najafabadi et al, in press), morphometry (Izadi-Najafabadi et al, 2020), and diffusion imaging analyses did not show similar neural mechanism following the CO-OP.…”

Section: No Observed Neuroplasticity In Children With Dcd + Adhdcontrasting

confidence: 57%

“…The bilateral sensorimotor tracts immediately beneath the superior corona radiata transfer motor information from the primary motor cortex (M1) and supplementary motor area (SMA) through the corticospinal tract (Klöppel et al, 2008;Vergani et al, 2014). High FA in the superior corona radiata is also associated with improved focused and sustained attention (Stave et al, 2017) and has previously been reported in a different analysis of CO-OP-induced structural changes (Izadi-Najafabadi et al, 2020). The current analysis provides further evidence of the potential role of the CO-OP in attention regulation and motor execution.…”

Section: Attention and Self-regulationmentioning

confidence: 75%

“…In contrast, children in the waitlist group were scanned 3 months after their first MRI, received their pre-assessments and intervention, followed by a third (post-treatment) MRI. A study design schematic (Izadi-Najafabadi et al, 2020 ) can be found elsewhere.…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

Izadi‐Najafabadi

Zwicker

2021

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

Background and Objectives: Children with developmental coordination disorder (DCD) have difficulty learning motor skills, which can affect their participation in activities of daily living and psychosocial well-being. Over 50% of children with DCD also have attention deficit hyperactivity disorder (ADHD), which further exacerbates their motor problems and impact on quality of life. A rehabilitation approach known as Cognitive Orientation to Occupational Performance uses problem-solving strategies to help children learn motor skills they wish to achieve. While this cognitive approach has been effective for children with DCD, few studies have examined the effectiveness of this approach for children with co-occurring ADHD. Further, the underlying mechanism and neural basis of this intervention are largely unknown.Methods: In this randomized waitlist-controlled trial, we used MRI to examine white matter microstructure after intervention in 8–12-year-old children with DCD (n = 28) and with DCD and co-occurring ADHD (n = 25). Children in both groups were randomized to either a treatment group or waitlist group at their first MRI. The treatment group began the intervention after their MRI scan and returned for a post-treatment scan at 3 months, and follow-up scan at 6 months; the waitlist group waited 3 months before their second MRI, received the intervention, and then had a post-treatment scan. Each child received intervention once weekly for 10 weeks. Diffusion tensor imaging was used to acquire white matter diffusion parameters and was analyzed using tract-based spatial statistics (TBSS).Results and Conclusion: Children with DCD showed significant improvement in white matter microstructure in the bilateral anterior thalamic radiation, bilateral sensorimotor tract, bilateral cingulum, fornix, splenium and body of corpus callosum, right inferior fronto-occipital fasciculus, and white matter pathways to bilateral inferior gyri, right middle frontal gyrus, frontal medial cortex, and left cuneus. We suggest that these rehabilitation-induced neural changes in children with DCD occurred in regions associated with attention, self-regulation, motor planning, and inter-hemispheric communication, which positively affected brain connectivity and motor function. In contrast, children with DCD and co-occurring ADHD did not show any brain changes following the intervention. Modifications to the treatment protocol might help address the attentional and self-regulatory needs of children with a dual diagnosis.Clinical Trial Registration: ClinicalTrials.gov ID: NCT02597751.

show abstract

Section: Motor Performancecontrasting

confidence: 84%

Section: Motor Performancecontrasting

confidence: 73%

Section: No Observed Neuroplasticity In Children With Dcd + Adhdcontrasting

confidence: 57%

Section: Attention and Self-regulationmentioning

confidence: 75%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

Izadi‐Najafabadi

Zwicker

2021

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

Differences in White Matter Microstructure Among Children With Developmental Coordination Disorder

et al. 2020

View full text Add to dashboard Cite

IMPORTANCE Developmental coordination disorder (DCD) is a motor impairment that significantly interferes with activities of daily living. Little is known about the cause of DCD and how it develops, making it difficult to understand why children with DCD struggle in learning motor skills and to determine the best intervention to optimize function.OBJECTIVE To characterize white matter differences using diffusion tensor imaging in children with and without DCD. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study collected diffusion tensorimaging data at BC Children' MAIN OUTCOMES AND MEASURESThe main outcome measures were diffusion parameters, including fractional anisotropy and mean, axial, and radial diffusivity, which are thought to provide an indirect measure of white matter microstructure. Tract-based spatial statistics, a voxelwise statistical analysis of diffusion parameters, were conducted using a 2-group comparison design matrix with age and attention as covariates. RESULTSThirty children without DCD (mean [SD] age, 9.9 [1.4] years; 21 [70%] boys) and 31 children with DCD (mean [SD] age, 10.1 [1.2] years; 26 [84%] boys) were included in the study. Compared with children without DCD, children with DCD were characterized by significantly lower fractional anisotropy and axial diffusivity in regions of white matter pathways associated with motor and sensorimotor processing, including the corticospinal tract (fractional anisotropy: mean [SD], 0.54 [0.03] vs 0.51 [0.03]; P < .001; axial diffusivity: mean [SD], 0.13 [0.98] vs 0.12 [0.46]; P = .01), posterior thalamic radiation at the retrolenticular part of the internal capsule (axial diffusivity: mean [SD], 0.14 [0.57] vs 0.14 [0.44]; P = .01), and cerebellar pathways (eg, superior cerebellar peduncle, fractional anisotropy: mean [SD], 0.49 [0.05] vs 0.46 [0.03]; P = .03; axial diffusivity: mean [SD], 0.14 [0.66] vs 0.14 [0.63]; P = .009). There were no significant differences in mean diffusivity and radial diffusivity between children with and without DCD. CONCLUSIONS AND RELEVANCE These findings suggest that children with DCD show significant brain differences in motor and sensorimotor white matter pathways compared with children without DCD. The pattern of diffusion parameters in children with DCD suggests that axonal development may be disrupted in this neurodevelopmental disorder. Question What white matter microstructural differences are associated with children with developmental coordination disorder (DCD) compared with children without DCD? Findings In this cross-sectional study of 31 children with DCD and 30 children without DCD, widespread differences in indices of white matter microstructure, including fractional anisotropy and axial diffusivity, were observed in children with DCD compared with children without DCD. Meaning These findings suggest that DCD does not simply represent the low end of typical motor skill ability; these children display altered brain development in sensorimotor pathways.Vancouver, British Columbia, Canada; caseload...

show abstract

Cognitive strengths in neurodevelopmental disorders, conditions and differences: A critical review

Maw,

Beattie,

Burns

2024

Neuropsychologia

View full text Add to dashboard Cite

Training-Induced Neuroplasticity in Children with Developmental Coordination Disorder

Cited by 14 publications

References 115 publications

White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial

Differences in White Matter Microstructure Among Children With Developmental Coordination Disorder

Cognitive strengths in neurodevelopmental disorders, conditions and differences: A critical review

Contact Info

Product

Resources

About