Training Preserves the Intestinal Cytokine Response to Acute Exercise in Older Mice

Packer, N; Hoffman‐Goetz, Laurie

doi:10.1249/mss.0b013e318238c5e3

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Furthermore, exercise may increase the number of SCFA-producing bacteria in both rodents and humans [ 163 , 164 ]. Moreover, preclinical studies have shown that exercise increases the activity of key antioxidant enzymes (catalase and glutathione peroxidase), anti-inflammatory cytokines (including interleukin 10; IL-10) and anti-apoptotic proteins (including Bcl-2) in intestinal lymphocytes, while reducing the level of pro-inflammatory cytokines (TNF-α and IL-17) and pro-apoptotic proteins (caspases 3 and 7) [ 165 , 166 ]. As a result, exercise may lead to an overall reduction in inflammation and the subsequent improvement of existing PD.…”

Section: Dietary Interventionsmentioning

confidence: 99%

Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review

Iwaniak,

Owe-Larsson,

Urbańska

2024

IJMS

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In the era of a steadily increasing lifespan, neurodegenerative diseases among the elderly present a significant therapeutic and socio-economic challenge. A properly balanced diet and microbiome diversity have been receiving increasing attention as targets for therapeutic interventions in neurodegeneration. Microbiota may affect cognitive function, neuronal survival and death, and gut dysbiosis was identified in Parkinson’s disease (PD). Tryptophan (Trp), an essential amino acid, is degraded by microbiota and hosts numerous compounds with immune- and neuromodulating properties. This broad narrative review presents data supporting the concept that microbiota, the Trp-kynurenine (KYN) pathway and aryl hydrocarbon receptors (AhRs) form a triad involved in PD. A disturbed gut–brain axis allows the bidirectional spread of pro-inflammatory molecules and α-synuclein, which may contribute to the development/progression of the disease. We suggest that the peripheral levels of kynurenines and AhR ligands are strongly linked to the Trp metabolism in the gut and should be studied together with the composition of the microbiota. Such an approach can clearly delineate the sub-populations of PD patients manifesting with a disturbed microbiota–Trp-KYN–brain triad, who would benefit from modifications in the Trp metabolism. Analyses of the microbiome, Trp-KYN pathway metabolites and AhR signaling may shed light on the mechanisms of intestinal distress and identify new targets for the diagnosis and treatment in early-stage PD. Therapeutic interventions based on the combination of a well-defined food regimen, Trp and probiotics seem of potential benefit and require further experimental and clinical research.

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Section: Dietary Interventionsmentioning

confidence: 99%

Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review

Iwaniak,

Owe-Larsson,

Urbańska

2024

IJMS

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“…Es gab keine unerwünschten Nebenwirkungen. Ein systematischer Review schlussfolgert, dass Bewegung einen positiven Effekt hat, inkludierte aber hauptsächlich keine RCTs 792 .…”

Section: Ernährung Und Komplementäre Verfahrenunclassified

Aktualisierte S3-Leitlinie Colitis ulcerosa (Version 6.2)

Kucharzik,

Dignass,

Atreya

et al. 2024

Z Gastroenterol

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“…Modulation of inflammatory states by physical exercise plays an important role in gut microbiota and health, since an increase in anti-inflammatory cytokines and antiapoptotic proteins in gut lymphocytes and a reduction in pro-inflammatory cytokines due to physical exercise may lead to a reduction in gut inflammation [264][265][266][267]. Indeed, voluntary wheel running was shown to have an immune-regulatory impact by reducing Turicibacter species in feces and caecum in rodents [195].…”

Section: Physical Exercise and Gut Microbiotamentioning

confidence: 99%

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

Souza,

de Araujo Borba,

Castro de Jesus

et al. 2023

IJMS

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Major depressive disorder (MDD) has a high prevalence and is a major contributor to the global burden of disease. This psychiatric disorder results from a complex interaction between environmental and genetic factors. In recent years, the role of the gut microbiota in brain health has received particular attention, and compelling evidence has shown that patients suffering from depression have gut dysbiosis. Several studies have reported that gut dysbiosis-induced inflammation may cause and/or contribute to the development of depression through dysregulation of the gut–brain axis. Indeed, as a consequence of gut dysbiosis, neuroinflammatory alterations caused by microglial activation together with impairments in neuroplasticity may contribute to the development of depressive symptoms. The modulation of the gut microbiota has been recognized as a potential therapeutic strategy for the management of MMD. In this regard, physical exercise has been shown to positively change microbiota composition and diversity, and this can underlie, at least in part, its antidepressant effects. Given this, the present review will explore the relationship between physical exercise, gut microbiota and depression, with an emphasis on the potential of physical exercise as a non-invasive strategy for modulating the gut microbiota and, through this, regulating the gut–brain axis and alleviating MDD-related symptoms.

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Training Preserves the Intestinal Cytokine Response to Acute Exercise in Older Mice

Cited by 5 publications

References 36 publications

Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review

Microbiota, Tryptophan and Aryl Hydrocarbon Receptors as the Target Triad in Parkinson’s Disease—A Narrative Review

Aktualisierte S3-Leitlinie Colitis ulcerosa (Version 6.2)

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

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