The behavioral research on teaching individuals who have profound multiple handicaps is reviewed. The primary focus is on determining the degree to which behavioral research has demonstrated the teaching of meaningful skills to this population. Results of the review indicate that investigations have demonstrated, albeit inconsistently, that behavior change has resulted from contingency management interventions with persons who have profound multiple handicaps. However, there is little evidence that such interventions have resulted in meaningful behavior change according to currently accepted criteria for beneficially affecting the quality of life of persons with serious handicaps. Potential explanations for the lack of such evidence are offered, induding the relative lack of research attention given to this issue, the possible ineffectiveness of the components of the technology applied, and possible ineffective application of the potentially effective technology. Suggestions for future research are discussed in terms of developing more effective educational and habilitative services for persons with profound multiple handicaps. In particular, we suggest research on a wider variety of behavioral teaching procedures, providing more comprehensive evaluations of the applications of procedures and developing treatment programs that do not focus solely on traditional skill acquisition.DESCRIPTORS: profound multiple handicaps, developmental disabilities, behavioral research methodology Since the early 1960s, one of the most significant areas of impact of applied behavioral research has been developmental disabilities. Hundreds of investigations have reported the successful use of behavioral procedures to improve adaptive functioning and decrease maladaptive behaviors of persons who have developmental disabilities (see Matson & Mulick, 1983;Whitman, Scibak, & Reid, 1983, for selected reviews). However, although the overall impact of applied behavioral research in this area has been quite significant, there is one population of persons with developmental disabilities for whom the impact has not been dear. Specifically, the utility of behavioral procedures for affecting adaptive behavior change among individuals who have profound mental and physical handicaps has been seriously questioned (Landesman-Dwyer & Sackett, 1978;Rainforth, 1982 (Guess et al., 1988). The most common descriptor used with standardized quantification is profound mental retardation (Grossman, 1983). However, profound mental retardation as a diagnostic dassification includes a very heterogeneous group of persons with a wide range of skills and disabilities (Bailey, 1981;Rainforth, 1982). Our concern is with those persons whose handicaps are so debilitating that they fall at the extreme lower end of the continuum of profound mental retardation and who also possess profound physical impairments, such that no existing standardized intelligence tests are applicable (cf. Bailey, 1981).We will refer to the population of concern here as individuals who have ...