Trait anxiety mediates the association between hippocampal–insula functional connectivity and anxiety symptom severity in adults with and without generalized anxiety disorder

Liu, Shiyu; Cao, Lingxiao; Li, Hailong; Du, Yang; Wang, Mei; Xiao, Hongqi; Duan, Yingxu; Deng, Gaoju; Huang, Xiaoqi; Qiu, Changjian; Gong, Qiyong

doi:10.1016/j.jad.2023.10.006

Journal of Affective Disorders

2024

DOI: 10.1016/j.jad.2023.10.006

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Trait anxiety mediates the association between hippocampal–insula functional connectivity and anxiety symptom severity in adults with and without generalized anxiety disorder

Shiyu Liu,

Lingxiao Cao,

Hailong Li

et al.

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Cited by 4 publications

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Su,

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Journal of Affective Disorders

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Reliability and validity of facial expression recognition in the screening of generalized anxiety disorder

Ren,

Su,

Jiang

et al. 2025

Journal of Affective Disorders

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Shared and distinctive dysconnectivity patterns underlying pure generalized anxiety disorder (GAD) and comorbid GAD and depressive symptoms

Yan,

Han,

Shan

et al. 2024

Journal of Psychiatric Research

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Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study

Yang,

Zhang,

et al. 2024

Journal of Diabetes

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BackgroundType 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and is often accompanied by mild cognitive impairment (MCI). The detrimental effects of T2DM and IR on the hippocampus have been extensively demonstrated. Few studies have examined the effects of IR on structure and function of hippocampal subfields in T2DM‐MCI patients.MethodA total of 104 T2DM patients were recruited in this prospective study and divided into four groups (T2DM‐MCI‐higherIR, n = 17; T2DM‐MCI‐lowerIR, n = 32; T2DM‐nonMCI‐higherIR, n = 19; T2DM‐nonMCI‐lowerIR, n = 36). Structure and function MRI data were captured. Clinical variables and neuropsychological scores were determined for all participants. Hippocampal subfield volume and functional connectivity were compared among four groups. Partial correlation analysis was performed between imaging indicators, clinical variables, and neuropsychological scores in all patients.ResultsT2DM‐MCI‐higher IR group had the smallest volumes of bilateral hippocampal tail, right subiculum‐body, right GC‐ML‐DG‐body, and right CA4‐body. IR in right hippocampal tail, right subiculum‐body, and right GC‐ML‐DG‐body exerted main effect. Furthermore, elevated functional connectivity was found between right subiculum‐body and bilateral dorsolateral prefrontal cortex and right anterior cingulate–medial prefrontal cortex. Hippocampal subfield volume positively correlates with total cholesterol and triglycerides and negatively correlates with fasting insulin.ConclusionThe present study found that T2DM‐MCI patients have structural and functional alterations in hippocampal subfields, and IR is a negative factor influencing the alteration of hippocampal subfields volume. These findings support the importance of IR in T2DM‐MCI patients and might be potential neuroimaging biomarkers of cerebral impairment in T2DM‐MCI patients.image

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Trait anxiety mediates the association between hippocampal–insula functional connectivity and anxiety symptom severity in adults with and without generalized anxiety disorder

Cited by 4 publications

References 54 publications

Reliability and validity of facial expression recognition in the screening of generalized anxiety disorder

Reliability and validity of facial expression recognition in the screening of generalized anxiety disorder

Shared and distinctive dysconnectivity patterns underlying pure generalized anxiety disorder (GAD) and comorbid GAD and depressive symptoms

Structural and functional alterations of the hippocampal subfields in T2DM with mild cognitive impairment and insulin resistance: A prospective study

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