Trajectories of Gait Speed Predict Mortality in Well-Functioning Older Adults: The Health, Aging and Body Composition Study

White, Daniel K.; Neogi, Tuhina; Nevitt, Michael C.; Peloquin, Christine; Zhu, Yanyan; Boudreau, Robert M.; Cauley, Jane A.; Ferrucci, Luigi; Harris, Tamara B.; Satterfield, S.; Simonsick, Eleanor M.; Strotmeyer, Elsa S.; Zhang, Yuqing

doi:10.1093/gerona/gls197

Cited by 206 publications

(154 citation statements)

References 31 publications

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“…Walking speed trajectories demonstrating rapid decline are associated more strongly with mortality than trajectories that are more stable (White et al, 2013). Therefore, determining rate of change, in addition to amount of change, of an individual’s WS may be of value.…”

Section: Responsiveness Of Walking Speedmentioning

confidence: 99%

Walking Speed: The Functional Vital Sign

Middleton

Fritz

Lusardi

2015

Journal of Aging and Physical Activity

933

608

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Walking speed (WS) is a valid, reliable, sensitive measure appropriate for assessing and monitoring functional status and overall health in a wide range of populations. These capabilities have led to its designation as the “6th vital sign”. By synthesizing the available evidence on WS, this scholarly review article provides clinicians with a reference tool regarding this robust measure. Recommendations on testing procedures for assessing WS, including optimal distance, inclusion of acceleration/deceleration phases, instructions, and instrumentation are given. After assessing an individual’s WS, clinicians need to know what this value represents. Therefore, WS cut-off values and the corresponding predicted outcomes, as well as minimal detectable change values for specific populations and settings are provided.

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Section: Responsiveness Of Walking Speedmentioning

confidence: 99%

Walking Speed: The Functional Vital Sign

Middleton

Fritz

Lusardi

2015

Journal of Aging and Physical Activity

933

608

View full text Add to dashboard Cite

show abstract

“…Usual Gait Speed (UGS) is supported in the literature as a valid means of predicting falls 25 , 26 and correlates with mortality, [27][28][29] disability, 30 , 31 and several other negative health outcomes. 32 Senior athletes have already demonstrated greater Fast Gait Speed (FGS) 11 than less active older adults, and current literature encourages the use of FGS in the testing of high-functioning seniors.…”

Section: Gait Speedmentioning

confidence: 99%

Fall History and Associated Physical Performance Measures in Competitive Senior Athletes

Jordre

Schweinle

Oetjen

et al. 2016

Topics in Geriatric Rehabilitation

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“…Walking speed has been shown to predict mortality, disability, cognitive decline, dementia and health care utilization (1-7). A meaningful decline in walking speed has been defined and shown to independently predict mortality (8, 9).…”

Section: Introductionmentioning

confidence: 99%

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

Suire

Eitan

Shaffer

et al. 2017

Experimental Gerontology

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Background Brain-derived neurotrophic factor (BDNF) is produced by cleavage of proBDNF, and BDNF and proBDNF may play antagonistic roles in nervous system development, learning, memory and neuronal stress resistance. BDNF and proBDNF are present in blood, but the origin and relative contributions of soluble and extracellular vesicle (EV)-associated levels are unknown. Methods In this study we used validated immunoassays to measure proBDNF and BDNF levels in plasma, total plasma EVs and a subpopulation of EVs enriched for neuronal origin (expressing the neuronal marker L1CAM) in 150 Baltimore Longitudinal Study of Aging participants with and without decline in walking speed (reflecting aging-associated motor decline). Results Levels of BDNF and proBDNF were highest in L1CAM+ EVs. Participants with walking speed decline had higher levels of proBDNF in L1CAM+ EVs compared to non-decliners, but no differences in proBDNF levels in plasma and total EV. Conclusions Our findings suggest that levels of proBDNF and BDNF in circulating L1CAM+ EVs might be used as biomarkers for conditions involving altered BDNF signaling.

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Trajectories of Gait Speed Predict Mortality in Well-Functioning Older Adults: The Health, Aging and Body Composition Study

Abstract: Despite being well-functioning at baseline, a quarter of older adults experienced fast decline in gait speed, which was associated with an increased risk of mortality.

Cited by 206 publications

References 31 publications

Walking Speed: The Functional Vital Sign

Walking Speed: The Functional Vital Sign

Fall History and Associated Physical Performance Measures in Competitive Senior Athletes

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

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