Trajectory and predictors of quality of life in first episode psychotic mania

Oldis, Meredith; Murray, Greg; Macneil, Craig A.; Hasty, Melissa K.; Daglas, Rothanthi; Berk, Michael; Conus, Philippe; Cotton, Sue

doi:10.1016/j.jad.2016.02.018

Cited by 15 publications

(7 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Quality of life is reduced in both symptomatic and non‐symptomatic patients when compared to healthy controls,15, 16, 17 and several domains of functioning have been identified by patients as being of particular importance‐ including physical, sleep, mood, cognition, leisure, social, spirituality, finances, household, self‐esteem, independence, identity, work, and education 18. For both psychosocial functioning and quality of life, impairments are more pronounced in patients with depressive symptoms,19, 20, 21 in those with more previous episodes/longer duration of illness,20, 22 and in those with lower cognition 23…”

Section: Foundations Of Managementmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

Self Cite

View full text Add to dashboard Cite

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. These advances have been translated into clear and easy to use recommendations for first, second, and third‐ line treatments, with consideration given to levels of evidence for efficacy, clinical support based on experience, and consensus ratings of safety, tolerability, and treatment‐emergent switch risk. New to these guidelines, hierarchical rankings were created for first and second‐ line treatments recommended for acute mania, acute depression, and maintenance treatment in bipolar I disorder. Created by considering the impact of each treatment across all phases of illness, this hierarchy will further assist clinicians in making evidence‐based treatment decisions. Lithium, quetiapine, divalproex, asenapine, aripiprazole, paliperidone, risperidone, and cariprazine alone or in combination are recommended as first‐line treatments for acute mania. First‐line options for bipolar I depression include quetiapine, lurasidone plus lithium or divalproex, lithium, lamotrigine, lurasidone, or adjunctive lamotrigine. While medications that have been shown to be effective for the acute phase should generally be continued for the maintenance phase in bipolar I disorder, there are some exceptions (such as with antidepressants); and available data suggest that lithium, quetiapine, divalproex, lamotrigine, asenapine, and aripiprazole monotherapy or combination treatments should be considered first‐line for those initiating or switching treatment during the maintenance phase. In addition to addressing issues in bipolar I disorder, these guidelines also provide an overview of, and recommendations for, clinical management of bipolar II disorder, as well as advice on specific populations, such as women at various stages of the reproductive cycle, children and adolescents, and older adults. There are also discussions on the impact of specific psychiatric and medical comorbidities such as substance use, anxiety, and metabolic disorders. Finally, an overview of issues related to safety and monitoring is provided. The CANMAT and ISBD groups hope that these guidelines become a valuable tool for practitioners across the globe.

show abstract

Section: Foundations Of Managementmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…9 Patients with bipolar disorder live about half their life in a symptomatic state, primarily one of depressive symptoms, which may carry a risk of interfering with continuous employment. 10,11 In patients with depressive symptoms, impairment of psychosocial function is more severe, [12][13][14] and often prevents them from maintaining the ability to function at work. 15 Patients with bipolar disorder have also been found to have functional impairment between episodes.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Mood Episode and Employment Status of Outpatients with Bipolar Disorder: Retrospective Cohort Study from the Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Clinics (MUSUBI) Project

Konno¹,

Fujino²,

Ikenouchi³

et al. 2021

NDT

View full text Add to dashboard Cite

The objective of this study was to clarify the relationship between mood episode and employment in patients with bipolar disorder to help improve their employment status. Methods: All medical records of patients with bipolar disorder who visited 176 member clinics of the Japanese Association of Neuro-Psychiatric Clinics in September-October 2016 were investigated in September-October 2017. Details of the medical care received were investigated using a survey sheet, which included employment status. Odds ratios of mood episodes for employment status were analyzed using a logistic regression model. Results: Among patients aged 60 years or less, 2292 described their occupation. On univariate analysis, odds ratios were statistically significant for depressive episode (OR = 2.68 [1.50-4.78] p = 0.001) and manic episode (OR = 2.64 [1.07-6.47] p = 0.034), whereas no significant difference was noted for mixed episode (OR = 1.72 [0.69-4.33] p = 0.246). On multivariate analysis, odds ratios were statistically significant for depressive episode (OR = 2.16 [1.13-4.13], p = 0.020) and manic episode , p = 0.010), whereas no significant difference was noted for mixed episode ] p = 0.254). Conclusion: Employment status among these patients with bipolar disorder receiving outpatient treatment was 43.5%. Compared to remission episodes, manic and depressive episodes were associated with a higher risk of unemployment.

show abstract

“…However, cross-sectional studies cannot illuminate directionality of effects. Limited investigation of the trajectory of QoL following first episode psychotic mania did not reveal an effect of symptoms at baseline with QoL at 18 months (Oldis et al 2016): more sensitive analyses of time-varying relationships in the general BD population is needed to illuminate possible relationships. Additionally, although QoL change is typically assumed to be a downstream consequence of symptom changes in BD, it is not known whether changes in QoL may have reciprocal impacts on BD symptoms: potentially, improvements in wellbeing and functioning could moderate symptoms of the disorder (Murray & Michalak, 2012).…”

mentioning

confidence: 99%

Quality of life in bipolar disorder: towards a dynamic understanding

et al. 2017

View full text Add to dashboard Cite

The present investigation illustrates real-world outcomes for QoL under guideline-driven BD treatment: improvements in mental QoL and decrements in physical QoL were observed. The data permitted investigation of dynamic interactions between QoL and symptoms, generating novel evidence for bidirectional effects and encouraging further research into this important interplay. Investigation of relevant time-varying covariates (e.g. medications) was beyond scope. Future research should investigate possible determinants of QoL and the interplay between symptoms and wellbeing/satisfaction-centric measures of QoL.

show abstract

Trajectory and predictors of quality of life in first episode psychotic mania

Cited by 15 publications

References 78 publications

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

Relationship Between Mood Episode and Employment Status of Outpatients with Bipolar Disorder: Retrospective Cohort Study from the Multicenter Treatment Survey for Bipolar Disorder in Psychiatric Clinics (MUSUBI) Project

Quality of life in bipolar disorder: towards a dynamic understanding

Contact Info

Product

Resources

About