Trajectory in obsessive-compulsive disorder comorbidities

Mathis, Maria Alice de; Diniz, Juliana Belo; Hounie, Ana Gabriela; Shavitt, Roseli Gedanke; Fossaluza, Victor; Ferrão, Ygor Arzeno; Leckman, James F.; Pereira, Carlos Alberto de Bragança; Rosario, Maria Conceição do; Miguel, Eurí­pedes Constantino

doi:10.1016/j.euroneuro.2012.08.006

Cited by 83 publications

(66 citation statements)

References 33 publications

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“…Bayesian 95 % credible intervals and nonparametric Tukey 95 % confidence intervals were used [33,34]. These refusal or failure to complete interview or consent form (18.8 %), registry by non-biological parent (9.2 %); provided invalid phone contacts/fail contact (5.3 %), other (2.6 %); (double asterisk): school transfer (12.3 %); others (0.61 %); triple asterisk refusal or failure to complete the interviews or consent form (16.2 %); fail contact (8.6 %), other (0.5 %) methods minimize bias due to high variance, enable comparison between groups (statistical similarities or statistical differences), and have been used successfully in previous studies [5]. Finally, to verify categorical sociodemographics variables, we conducted a two-tailed Fisher exact test [35] and Kruskal-Wallis exact test [36].…”

Section: Discussionmentioning

confidence: 96%

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Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children

Alvarenga

Rosario

Cesar

et al. 2015

Eur Child Adolesc Psychiatry

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Pediatric-onset obsessive-compulsive disorder (OCD) is underdiagnosed, and many affected children are untreated. The present study seeks to evaluate the presence and the clinical impact of OCD and obsessive-compulsive symptoms (OCS) in a large sample of school-age children. In Phase I, we performed an initial screening using the Family History Screen (FHS). In Phase II, we identified an "at-risk" sample, as well as a randomly selected group of children. A total of 2,512 children (6-12 years old) were assessed using the FHS, the Development and Well-Being Assessment (DAWBA), the Strengths and Difficulties Questionnaire (SDQ), and the Child Behavior Checklist (CBCL). Data analyses included descriptive and multivariate analytical techniques. 2,512 children (mean age: 8.86 ± 1.84 years; 55.0% male) were categorized into one of the three diagnostic groups: OCD (n = 77), OCS (n = 488), and unaffected controls (n = 1,947). There were no significant socio-demographic differences (age, gender, socioeconomic status) across groups. The OCS group resembled the OCD on overall impairment, including school problems and delinquent behaviors. However, the OCD group did have significantly higher rates of several comorbid psychiatric disorders, including separation anxiety, generalized anxiety, and major depressive disorder, than OCS or unaffected controls. Moreover, the OCD group also scored higher than the SDQ, as well as on each of CBCL items rated by the parent. Our findings suggest that there is a psychopathological continuum between OCS and OCD in school-aged children. The presence of OCS is associated with functional impairment, which needs further investigation in longitudinal studies.

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Section: Discussionmentioning

confidence: 96%

“…The onset of the first obsessive-compulsive symptoms (OCS) occurs during childhood in the majority of cases [3][4][5]. However, data on the prevalence of OCD among children and adolescents are scarce.…”

Section: Introductionmentioning

confidence: 99%

Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children

Alvarenga

Rosario

Cesar

et al. 2015

Eur Child Adolesc Psychiatry

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“…Comorbidity, in particular, can infl uence presentation, long-term outcome, and treatment response of OCD patients, with negative impact on health and psychosocial function (De Mathis et al 2013;Fineberg et al 2013;Jakubovski et al 2013).…”

mentioning

confidence: 99%

Characterizing impulsivity profile in patients with obsessive–compulsive disorder

Benatti

Dell’Osso

Arici

et al. 2013

International Journal of Psychiatry in Clinical Practice

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“…Also, psychomotor re-education for motor control can be necessary in some cases. In terms of psychosocial interventions, clinical psychotherapy can be introduced to cope with comorbidities such as depressive and anxiety symptoms, self-esteem issues, lack of control of hyperactivity, and impulse symptoms (de Mathis et al, 2013).…”

Section: Pharmacotherapymentioning

confidence: 99%