2024
DOI: 10.1101/2024.01.26.577510
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Trajectory inference from single-cell genomics data with a process time model

Meichen Fang,
Gennady Gorin,
Lior Pachter

Abstract: Single-cell transcriptomics experiments provide gene expression snapshots of heterogeneous cell populations across cell states. These snapshots have been used to infer trajectories and dynamic information even without intensive, time-series data by ordering cells according to gene expression similarity. However, while single-cell snapshots sometimes offer valuable insights into dynamic processes, current methods for ordering cells are limited by descriptive notions of ''pseudotime'' that lack intrinsic physica… Show more

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