Trajectory of cognitive impairments over 1 year after COVID‐19 hospitalisation: Pattern, severity, and functional implications

Miskowiak, Kamilla Woznica; Fugledalen, L; Jespersen, A E; Sattler, SM; Podlekareva, Daria; Rungby, Jørgen; Porsberg, CM; Johnsen, Stine

doi:10.1016/j.euroneuro.2022.04.004

Cited by 42 publications

(60 citation statements)

References 51 publications

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“…This suggests that even in mild types of COVID-19, there could be slight impairments in cognition after the recovery. These results are consistent with existing studies showing cognitive deficits in people affected by COVID-19 [ 35 , 36 ]. By now, the presence of long-lasting cognitive symptoms is evident, but the question of underlying mechanisms remains open: it is not clear both the cause of the pathological process itself and which functions are most susceptible to impairments [ 37 ].…”

Section: Discussionsupporting

confidence: 93%

The Impact of Mild COVID-19 on Executive Functioning and Mental Health Outcomes in Young Adults

et al. 2022

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COVID-19 is associated with a range of long-lasting symptoms related to cognitive and psycho-emotional spheres. Even mild cases of the disease can lead to persistent cognitive deficits and deterioration of the psycho-emotional state. The purpose of our study was to examine the presence and frequency of psycho-emotional disorders and cognitive deficits in students who recovered from mild form of COVID-19. A total of 40 COVID-19 survivors and 25 healthy controls participated in our study. We assessed three core cognitive functions (inhibition, working memory, task-switching), reaction time and motor speed. We also assessed depression, anxiety and fatigue with self-report questionnaires. The COVID-19 group manifested increased depression and decreased inhibition in comparison with the controls. Our results show that even in young adults who have recovered from mild COVID-19, there are persisting cognitive and psycho-emotional deficits.

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Section: Discussionsupporting

confidence: 93%

The Impact of Mild COVID-19 on Executive Functioning and Mental Health Outcomes in Young Adults

et al. 2022

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“…In addition, 6 months following the contracted infection available data revealed persistent cognitive impairment, implicating multiple domains (language, attention, and executive functions) ranging from 17.5 to 60.3% (64)(65)(66). Furthermore, one year after hospital discharge the percentage of patients with clinically relevant cognitive impairments was significant when compared to a matched healthy control group, with verbal learning and executive function being most affected (67,68).…”

Section: Cognitive Impairment and Covid-19 Infectionmentioning

confidence: 99%

Acute and long‑term psychiatric symptoms associated with COVID‑19 (Review)

et al. 2022

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Coronavirus disease 2019 (COVID-19) started spreading at the end of 2019 and despite the immediate actions of various governments with strict control, more and more individuals became infected daily. Due to the uncertainty and insecurity that still exists around this pandemic, there is an acute need for information and knowledge of what severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection entails. Respiratory and other physical symptoms received most of the medical attention, however, infected patients were also at risk for developing psychiatric and mental health disorders, such as depression, anxiety, and sleep disturbances. Available research reports a so-called 'post-COVID-19 syndrome', which refers to new and/or persistent signs and symptoms for over 12 weeks, following SARS. The aim of the present review was to provide a general overview of the psychiatric symptoms developed during SARS-CoV-2 infection and their long-term outcome, highlighting that, through follow-up with surviving patients it was revealed that some of the psychiatric symptoms of COVID-19 persisted for a long time after discharge and were also associated with negative effects on global functioning and lower quality of life.

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“…These deficits can last for a prolonged period of time and clinically 10.3389/fnagi. 2022.1020092 relevant cognitive impairments in verbal learning and executive function were found in 48% of patients 1 year following the onset of symptoms (Miskowiak et al, 2022).…”

Section: Covid-19-associated Cognitive Dysfunction and Neurodegenerat...mentioning

confidence: 99%

“…Another study found that 22% of individuals infected with SARS-CoV-2 developed symptoms of cognitive impairment, which remained after 12 weeks following their diagnosis ( Ceban et al, 2022 ). These deficits can last for a prolonged period of time and clinically relevant cognitive impairments in verbal learning and executive function were found in 48% of patients 1 year following the onset of symptoms ( Miskowiak et al, 2022 ).…”

Section: Covid-19-associated Cognitive Dysfunction and Neurodegenerationmentioning

confidence: 99%

Cognitive dysfunction associated with COVID-19: Prognostic role of circulating biomarkers and microRNAs

Alvarez

Trent

Goncalves

et al. 2022

Front. Aging Neurosci.

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COVID-19 is renowned as a multi-organ disease having subacute and long-term effects with a broad spectrum of clinical manifestations. The evolving scientific and clinical evidence demonstrates that the frequency of cognitive impairment after COVID-19 is high and it is crucial to explore more clinical research and implement proper diagnostic and treatment strategies. Several central nervous system complications have been reported as comorbidities of COVID-19. The changes in cognitive function associated with neurodegenerative diseases develop slowly over time and are only diagnosed at an already advanced stage of molecular pathology. Hence, understanding the common links between COVID-19 and neurodegenerative diseases will broaden our knowledge and help in strategizing prognostic and therapeutic approaches. The present review focuses on the diverse neurodegenerative changes associated with COVID-19 and will highlight the importance of major circulating biomarkers and microRNAs (miRNAs) associated with the disease progression and severity. The literature analysis showed that major proteins associated with central nervous system function, such as Glial fibrillary acidic protein, neurofilament light chain, p-tau 181, Ubiquitin C-terminal hydrolase L1, S100 calcium-binding protein B, Neuron-specific enolase and various inflammatory cytokines, were significantly altered in COVID-19 patients. Furthermore, among various miRNAs that are having pivotal roles in various neurodegenerative diseases, miR-146a, miR-155, Let-7b, miR-31, miR-16 and miR-21 have shown significant dysregulation in COVID-19 patients. Thus the review consolidates the important findings from the numerous studies to unravel the underlying mechanism of neurological sequelae in COVID-19 and the possible association of circulatory biomarkers, which may serve as prognostic predictors and therapeutic targets in future research.

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Trajectory of cognitive impairments over 1 year after COVID‐19 hospitalisation: Pattern, severity, and functional implications

Cited by 42 publications

References 51 publications

The Impact of Mild COVID-19 on Executive Functioning and Mental Health Outcomes in Young Adults

The Impact of Mild COVID-19 on Executive Functioning and Mental Health Outcomes in Young Adults

Acute and long‑term psychiatric symptoms associated with COVID‑19 (Review)

Cognitive dysfunction associated with COVID-19: Prognostic role of circulating biomarkers and microRNAs

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