Trajectory of vitamin D status during pregnancy in relation to neonatal birth size and fetal survival: a prospective cohort study

Bärebring, Linnea; Bullarbo, Maria; Glantz, Anna; Hulthén, Lena; Ellis, Joy; Jagner, Åse; Schoenmakers, Inez; Winkvist, Anna; Augustin, Hanna

doi:10.1186/s12884-018-1683-7

Cited by 40 publications

(51 citation statements)

References 23 publications

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“…A total of 1639 were excluded after reading titles and/or abstracts, and 75 articles were subjected to a full-text review. After reading the full text, a total of 24 cohorts were invited to participate, which included 13 cohort studies [27][28][29][30][31][32][33][34][35][36][37][38][39], seven case-control studies [40][41][42][43][44][45][46] and four cross-sectional studies [47][48][49][50].…”

Section: Search Resultsmentioning

confidence: 99%

“…Because three studies [29][30][31] of 24 measured serum 25(OH)D concentrations at two or three periods of pregnancies, our meta-analysis included nine studies [28][29][30][31]36,39,41,44,46] in the first trimester, 11 studies [27,[30][31][32][33][34][35]37,38,40,43] in the second trimester, and nine studies [29][30][31]42,45,[47][48][49][50] in the third trimester.…”

Section: Search Resultsmentioning

confidence: 99%

“…The included studies from the United States, Canada, Australia, New Zealand, Spain, Netherlands, Swedish, Poland, Brazil, Kenya, China, Singapore and Thailand. A total of nine studies [28,30,31,33,37,40,[48][49][50] were from Asian countries, six [36,41,43,[45][46][47] from American countries, five [29,34,38,39,42] from European countries, three [27,35,44] from Oceanian countries, and one [32] was from African countries. Among 24 studies, 21 [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] cohort studies or case-control studies were appraised by NOS, resulting with scores above 6, while four [47][48][49][50] cross-sectional studies were appr...…”

Section: Study Characteristicsmentioning

confidence: 99%

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Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Lian

et al. 2020

Preprint

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Background: Current studies suggest that vitamin D deficiency during pregnancy can produce a certain effect for preterm birth, but there is no research showing whether vitamin D deficiency has a consistent effect in different pregnancies; thus, we conducted a systematic review and meta-analysis of 24 observational studies, grouping them according to the gestational age at the time of serum sampling, to investigate whether vitamin D deficiency in different periods of gestation has different effects on preterm birth and to provide an evidence-based basis for pregnant women to measure and supplement vitamin D. Methods: The databases PubMed-Medline, EMBASE, the Cochrane Library, Web of Science, EBSCO, CBM, and CNKI were searched until July 2019. Two researchers independently assessed the eligibility and quality of studies, and STATA 12.0 software was used for meta-analysis. Result: Seven cohort studies, 13 case-control studies, and four cross-sectional studies were included from 2500 articles by inclusion and exclusion criteria. After adjusting for age, race, and other confounding factors, meta-analysis results showed that vitamin D deficiency in the first trimester, the second trimester and the third trimester did not increase the risk of preterm birth (odds ratio (OR) = 1.01, 95% confidence interval (CI) (0.88, 1.16), P = 0.867; OR = 1.12, 95%CI (0.92, 1.37), P = 0.249; OR = 1.05, 95%CI (0.87, 1.27), P = 0.602). However, there was moderate heterogeneity in the study of vitamin D deficiency in the second trimester, and subgroup analysis suggested that vitamin D deficiency in the second trimester may increase the risk of preterm birth (OR = 1.33, 95%CI (1.15, 1.54), P = 0.000). A sensitivity analysis of the second trimester showed that excluding any one study did not significantly change the results. Conclusions: Vitamin D deficiency in early and late pregnancy may not be associated with preterm birth, while vitamin D deficiency in middle pregnancy is likely to have an important effect on preterm birth. Vitamin D levels should be measured in the second trimester of pregnancy, and vitamin D supplements should be provided if necessary.

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Section: Search Resultsmentioning

confidence: 99%

Section: Search Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Lian

et al. 2020

Preprint

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“…It appears that vitamin D intake from food and supplements contributed signi cantly to 25OHD level in population, in which sun exposure is minimum or dermal synthesis of 25OHD is limited. For instances, recent studies from two high latitude countries, Sweden [49] and Switzerland [34,47] reported that supplements use, but not time spent outdoors was associated with decreased risk of VDD. Likewise, in a large Chinese study, Yun and colleagues [40] demonstrated that vitamin D supplements use was associated with vitamin D status during winter when the sun exposure is limited but not signi cantly associated during autumn.…”

Section: Discussionmentioning

confidence: 99%

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Lee

Ling

Tusimin³

et al. 2020

Preprint

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Background Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations. However, previous studies examining the factors associated with VDD during pregnancy were restricted to the study of only demographics and lifestyle factors or genetic factors alone. Thus, this study assesses the associations of GC gene polymorphism, environmental and lifestyle factors with VDD in Malaysian pregnant women. Method: Information on demographics, dietary vitamin D intake from supplement and food, time spent outdoors, skin type and clothing were collected by questionnaire. Plasma total 25-hydroxyvitamin D (25OHD) levels were measured using Ultra-High-Performance Chromatography (UHPLC). Maternal GC single nucleotide polymorphisms (SNPs) (rs4588 and rs7041) were determined using restriction fragment length polymorphism (RFLP). Results Results showed that 50.2% of pregnant women were vitamin D deficient (25OHD < 30 nmol/L). VDD (25OHD < 30 nmol/L) were significantly associated with age, veiled clothing, maternal vitamin D intakes, both from food and supplement, and GC rs7041(and GC diplotypes). In contrast to previous studies in non-pregnant population, this study found that CC genotype for SNP GC rs7041, GC 1 s-1 s and GC If-2 were significantly associated with increased risk of VDD (25OHD < 30 nmol/L). Conclusions The high prevalence of maternal VDD reported in the present study suggests the need for urgent development and implementation of vitamin D supplementation or fortification strategies to reduce VDD among pregnant women. The discrepancy in the association of GC rs7041 with VDD reflects the differential in the factors associated with vitamin D deficiency in pregnancy compared to non-pregnant state

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“…Indeed, current considerable amount of literature has been published on the association of vitamin D insu ciency with a number of diseases [5,6,7,8,9,10]. Especially, the inadequacy vitamin D during pregnancy is associated with adverse outcomes for mothers and the fetus or consequences on the offspring [11,12]. Recently, a study showed that increased preconception vitamin D concentrations, not in early pregnancy, are associated with reduced pregnancy loss.…”

Section: Introductionmentioning

confidence: 99%

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

Fan

Hui

Yan

et al. 2020

Preprint

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Background: Recent study found that vitamin D before conception was considered as a potential additional determinant for achieving pregnancy and live births. The study aimed to evaluate the serum 25 hydroxyvitamin D (25(OH)D) levels and its affecting factors among preconception fertile women. Methods: This cross-sectional study enrolled 410 women aged 22-44 years who attended a preconception genetic counseling clinic from January 2018 to May 2019. Sociodemographic characteristics and reproductive history of women were collected, and height and weight were measured. Serum 25(OH)D concentration was assayed with chemiluminescence immunoassay. Descriptive statistics were used to examine serum 25(OH)D concentration, and socio-demographic characteristics and reproductive history among preconception women. Determinants of vitamin D deficiency and its affecting factors were assessed using χ2 test. Results: Findings showed 84.4% of women had serum 25(OH)D concentration below 20 ng/mL. Women working indoors as well as without a history of childbirth had significantly lower 25(OH)D levels compared with those non-working individuals and having delivered a previous child (both P <0.05). The 25(OH)D levels were the lowest in winter than in spring, summer, and autumn (all P <0.001). Women in winter have significantly elevated OR of 5.00 (95%CI 1.75–14.25) to develop vitamin D deficiency. Seasonal variation in serum 25(OH)D levels was not present in non-working individuals and women aged 31-44 years. Conclusions: Vitamin D deficiency is common among preconception women especially nulliparous women and working women, which propose to screen serum 25(OH)D on preconception evaluation and emphasize need vitamin D supplements and get sunshine exposure.

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Trajectory of vitamin D status during pregnancy in relation to neonatal birth size and fetal survival: a prospective cohort study

Cited by 40 publications

References 23 publications

Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Does Vitamin D Deficiency in Different Periods of Gestation Have the Same Effect on Preterm Birth? A Systematic Review and Meta-Analysis

Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status in healthy Malaysian pregnant women

Serum 25 hydroxyvitamin D levels and affecting factors among preconception fertile women

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