Assistive care robots operate in cluttered, complex environments, akin to human residences, and need to face sensor and actuator faults during their operation without compromising safety. In these situations, the system must foresee and provide reactions that are beyond robust in addition to compensating for uncertainty and volatility in its functioning. We propose a new control design framework based on the principles of antifragility. In this work, we provide a formal concept of antifragile control and outline the design procedures for creating a mobile robot trajectory-tracking antifragile controller. An extended comparative evaluation against other controllers and a methodical investigation of the performance under parametrizable uncertainty and errors is also provided. Our findings demonstrate the effectiveness of antifragile closed-loop control in volatile and unanticipated circumstances.