This article focuses on the problem of robust adaptive safety control of a class of nonlinear systems with parametric uncertainties. Two novel definitions, that is, robust adaptive control Lyapunov function (RACLF) and robust adaptive control barrier function (RACBF) are introduced in this article. Also, an estimation of unknown parameters is obtained based on multiple identification models, state predictors and a logic switching mechanism. The switching mechanism plays a vital role in enhancing the transient properties of nonlinear systems. Meanwhile, a safe motion framework for differential robots is provided based on the existence of parametric uncertainties in RACLF and RACBF, and a safe and stable controller is obtained by solving quadratic programming. Finally, simulation results of differential robot capable of safe motion in space are presented to verify the validity of the design method.