Featured Application: Design and realization of robust, simple and effective controllers, mainly for the transportation and manufacturing systems.Abstract: This paper presents new theorems, which allow to design in a unified way robust proportional-derivative (PD)-type control laws without chattering for a broad class of uncertain nonlinear multi-input multi-output (MIMO) systems, subject to bounded disturbances and noises, of great theoretical and engineering relevance. These controllers are used to track a reference signal with bounded second derivative with the tracking error norm smaller than a prescribed value. The proposed control laws are simple to design and implement, above all for robotic systems, both in the case of a trajectory assigned in the joint space and in the workspace. The obtained theoretical results can have numerous applications. In this paper four significant applications are provided. The first one concerns the solution of a nonlinear equations system or the determination of an equilibrium point of a nonlinear system. The second case study deals with the inversion of a nonlinear vectorial function or the kinematic inversion of a robot. The third application concerns: (A) the tracking control of a robot with parametric uncertainties, with and without measurement noise on velocity, both in the joint space and the workspace; (B) the impedance control of a robot interacting with a human operator. The fourth case study addresses the tracking control of an uncertain nonlinear system that does not belong to the class of mechanical systems. Finally, an appendix is included, providing six easy examples, which show how the results proposed in the paper can eliminate and/or reduce serious disadvantages existing in the robust control literature for significant classes of linear and nonlinear uncertain systems.Keywords: general robust tracking control method; design of robust proportional-derivative-type controller; practical robust stability; robust control of mechanical uncertain systems; impedance control of a robot