TRALI – Definition, mechanisms, incidence and clinical relevance

Toy, Pearl; Lowell, Clifford A.

doi:10.1016/j.bpa.2007.01.003

Cited by 85 publications

(64 citation statements)

References 56 publications

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“…Besides antibodies against human leukocyte antigens, biologically active lipids (lysophosphatidylcholines [LysoPCs]) and cytokines, which are released and accumulate during storage of platelets products, have been implicated in the pathogenesis of TRALI. [8][9][10] Transfusion of (aged) platelet concentrates (PLTs) was found to be associated with the onset of TRALI and adverse outcome. [5][6][7] Mechanisms of the detrimental effect of PLTs on lung inflammation may include accumulation of soluble factors such as LysoPCs in the supernatant.…”

Section: Introductionmentioning

confidence: 99%

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

Vlaar

Hofstra

Kulik³

et al. 2010

Blood

100

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Transfusion-related acute lung injury is suggested to be a "2-hit" event resulting from priming and activation of pulmonary neutrophils. Activation may result from infusion of lysophosphatidylcholines (LysoPCs), which accumulate during storage of blood products. In the present study, we developed a syngeneic in vivo transfusion model to test whether storage of platelet concentrates (PLTs) results in lung injury in healthy rats as well as in a "2-hit" model using lipopolysaccharide-pretreated rats. In addition, the effect of washing of platelets was studied. In healthy rats, transfusion of aged PLTs caused mild lung inflammation. In LPS-pretreated rats, transfusion of aged PLTs, but not fresh PLTs, augmented pulmonary and systemic coagulopathy. When PLTs components were transfused separately, supernatant of aged PLTs, but not washed aged platelets, induced pulmonary injury in the "2-hit" model.

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Section: Introductionmentioning

confidence: 99%

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

Vlaar

Hofstra

Kulik³

et al. 2010

Blood

100

View full text Add to dashboard Cite

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“…We (1,3,4,8 (3,5). One interesting example of TRALI because of endothelial cell activation was reported by Dykes,et al (10) (13).…”

Section: Transfusion-related Acute Lung Injury (Trali) Is a Lifethreamentioning

confidence: 74%

“…The presence of anti-HLA or anti-granulocyte antibodies in the recipient has also been postulated to cause TRALI through activation of transfused donor granulocytes (3,12 …”

Section: T a B L E 1 T H E Re S U L T S O F A L Y Mp H O C Y T O T mentioning

confidence: 99%

Transfusion-Related Acute Lung Injury (TRALI) Induced by Donor-Derived Anti-HLA Antibodies in Aplastic Anemia: Possible Priming Effect of Granulocyte-Colony Stimulating Factor (G-CSF) on the Recipient Neutrophils

2009

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“…Zudem ist die Gabe von FFP risikobehaftet. Zu den Risiken zählen unter anderem das transfusionsassoziierte Lungenversagen [20], Transfusionsreaktionen, mögliche AB0-Inkompatibilität [21] sowie ein erhöhtes postoperatives Infektionsrisiko [22]. …”

Section: Medikamentöse Therapieunclassified

Postoperatives Management der Gerinnung

Sassenscheidt

Zöllner

2013

Visc Med

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Hintergrund: Das Gerinnungsmanagement in der postoperativen Phase stellt eine komplexe Herausforderung dar. Einerseits führt eine bereits präoperativ vorbestehende oder intraoperativ erworbene Beeinträchtigung der Blutgerinnung zu einem erhöhten Risiko für Nachblutungen. Andererseits sind Patienten in der postoperativen Phase einem erhöhten Risiko für thromboembolische Komplikationen ausgesetzt. Zudem drängen vermehrt neue orale Antikoagulanzien und Thrombozytenaggregationshemmer auf den Markt, für deren perioperativen Einsatz noch wenig Erfahrung besteht. Methode: Literaturübersicht. Ergebnisse: Das postoperative Gerinnungsmanagement sollte individualisiert nach einer Diagnostik mit klassischen Gerinnungstests und Point-of-Care(POC)-Diagnoseverfahren erfolgen. Verglichen mit dem intraoperativen Gerinnungsmanagement bestehen Unterschiede. Schlussfolgerungen: Das Ziel des postoperativen Gerinnungsmanagements ist eine Gerinnungsaktivität, die eine suffiziente Wundheilung zulässt, ohne thromboembolische Ereignisse zu begünstigen. Im Falle einer postoperativen Blutung sollte zur Diagnostik neben den klassischen Gerinnungstests auf viskoelastische POC-Verfahren zurückgegriffen werden. Neben der bedarfsadaptierten Substitution von Gerinnungsfaktoren ist die Aufrechterhaltung der Rahmenbedingungen der Gerinnung von entscheidender Bedeutung (Normothermie, physiologischer pH-Wert, Normokalziämie). Die Fortführung einer bestehenden Antikoagulation mit neuen oralen Antikoagulanzien ist eine Einzelfallentscheidung. Für ihren perioperativen Einsatz gib es noch keine Leitlinien.

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TRALI – Definition, mechanisms, incidence and clinical relevance

Abstract: Transfusion-related acute lung injury (TRALI) is defined as new acute lung injury (ALI) that occurs during or within six hours of transfusion, not explained by another ALI risk factor.

Cited by 85 publications

References 56 publications

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

Transfusion-Related Acute Lung Injury (TRALI) Induced by Donor-Derived Anti-HLA Antibodies in Aplastic Anemia: Possible Priming Effect of Granulocyte-Colony Stimulating Factor (G-CSF) on the Recipient Neutrophils

Postoperatives Management der Gerinnung

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