Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles

Sy, Papa Mady; Dieng, Sidy Mouhamed; Diouf, Louis Augustin Diaga; Djiboune, Alphonse Rodrigue; Soumboundou, Mamadou; Ndong, Boucar; Diop, Ousseynou; Bathily, E.H.A.L.; Mbaye, Marthe Diouf Gora; Mbodj, Mamadou; Diarra, Mounibé

doi:10.13189/ijbb.2018.060202

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Recently, the applications of emulsions stabilized by solid particles are reconsidered in biopharmaceutics. This type of formulation are potential system of encapsulation of drugs, allowing the controlled and targeted release of the asset from the internal phase 5,6,[16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems

Dieng²,

Djiboune³

et al. 2023

J. Drug Delivery Ther.

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This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing particles composed of magnesium carbonate particles. Pickering oil-in-water emulsions stabilized with magnesium carbonate particles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of magnesium carbonate particles on the physicochemical properties of Pickering emulsions. The O/W Pickering emulsion was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by magnesium carbonate particles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and magnesium carbonate particles allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs. Keywords: emulsion -Pickering-magnesium carbonate- ibuprofen-oral bioavailability

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Section: Introductionmentioning

confidence: 99%

O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems

Dieng²,

Djiboune³

et al. 2023

J. Drug Delivery Ther.

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Section: Introductionmentioning

confidence: 99%

pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study

Sy¹,

Diouf²,

Djiboune³

et al. 2020

EJB

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This study investigates the formulation of surfactant-free Pickering emulsions that release a drug at a specific pH to improve its oral bioavailability. The stabilizing nanoparticles composed of hydroxyapatite were obtained by a process of nanoprecipitation. Pickering oil-in-water emulsions stabilized with hydroxyapatite nanoparticles and encapsulating a hydrophobic drug model (ibuprofen) were formulated using a high-energy process with rotor-stator turbo mixer (IKA® T25 digital ultra-Turrax). The experimental approach explored the impact of all formulation parameters, dispersed phase and amount of hydroxyapatite nanoparticles on the physicochemical properties of Pickering emulsions. The system was characterized by a methylene blue test, pH and conductivity measurements, and droplet size determination. In addition, Pickering emulsions stabilized by hydroxyapatite nanoparticles have the advantage of being destabilized in acidic medium leading to the release of the active principle via the droplets. The acidic medium release study (pH equal to 1.2) showed ibuprofen release as a function of initial droplet loading and saturation concentration. In the simulated intestinal medium at pH equal to 6.8, we found a better release of ibuprofen from emulsions that already had saturation in an acid medium. Thus, the interest of these Pickering emulsions lies on the fact that their non-toxicity and hydroxyapatite nanoparticles have advantage of being biocompatible because having the same mineral composition as bones and teeth. In addition, they allow destabilization of the emulsions and release of the drug. These emulsions not only protect patients from the side effects of acid-based drugs, but also contribute to increase the bioavailability of these acidic drugs.

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Pickering Interfacial Catalysis—Knoevenagel Condensation in Magnesium Oxide-Stabilized Pickering Emulsion

2020

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In the present study, a novel catalytic route for the Knoevenagel condensation reaction has been developed by Pickering interfacial catalysis using magnesium oxide (MgO) as both an emulsion stabilizer and a base catalyst. MgO was prepared by the precipitation method using sodium hydroxide or ammonium hydroxide as the precipitating agent and calcined at different temperatures. The calcined samples were characterized by XRD, SEM, TEM, AFM, BET, and DLS techniques. The catalytic application of the emulsions stabilized by MgO was investigated for the Knoevenagel condensation reaction of benzaldehyde and its derivatives with malononitrile. All of the reactions were carried out at an ambient temperature (30 °C) under static conditions without stirring. Both the emulsion-stabilizing ability and the catalytic activity of MgO were found to be affected by the method of preparation, calcination temperature, and the nature of the oil phase. It was observed that the method of preparation varied the texture and morphology of MgO and thus the stability and droplet size of the emulsion formed. This was further reflected in the catalytic activity. The highest yield (87%) of the condensation product was obtained with MgO prepared by precipitation using a strong base (NaOH) and further calcined at 400 °C. The developed catalytic system offers several green chemistry advantages such as reusable solid-base catalyst and use of a single material as both emulsion stabilizer and catalyst. Room-temperature reaction under static conditions is an additional advantage of the developed catalytic system.

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Tramadol Encapsulation in Aqueous Phase of Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles

Cited by 3 publications

References 8 publications

O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems

O/W Pickering emulsion stabilized by magnesium carbonate particles for drug delivery systems

pH-sensitive Pickering Emulsion Stabilized by Hydroxyapatite Nanoparticles: Stability and Controlled Release Study

Pickering Interfacial Catalysis—Knoevenagel Condensation in Magnesium Oxide-Stabilized Pickering Emulsion

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