Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review

Merchante, Ignacio Morón; Pergolizzi, Joseph V.; Laar, Mart van de; Mellinghoff, Hans-Ulrich; Nalamachu, Srinivas; O'Brien, Joanne; Perrot, Serge; Raffa, Robert B.

doi:10.5402/2013/638469

Cited by 10 publications

(11 citation statements)

References 95 publications

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“…In the paracetamol only group nausea (25%) and epigastric pain (16.7%) were noted and in agreement to the published reports 11,12 . In the ultracet group drowsiness was the main adverse effect noted (11.9%) other adverse effects being nausea (7.1%) constipation (7.1%), insomnia and headache as reported earlier [13][14][15] (Table 2). The tramadol group saw constipation as the main adverse effect (13.3%) with nausea and drowsiness being seen in 6.7% of the patients ( Table 2).…”

Section: Discussionsupporting

confidence: 52%

Audit of Efficacy and Adverse Events of Analgesics Used to Mitigating Cancer Pain: Observations From a Tertiary Care Hospital

Simon¹,

Palatty²,

Thilakchand³

et al. 2018

IJMLR

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Introduction: Analgesics are the main stay in the mitigation of pain in cancer patients.However, depending on the type of analgesics, adverse events which at times can be severe are also observed. In this study an attempt has been made to understand the beneficial and adverse effects of the standard analgesics recommended for mitigating cancer pain. Materials and methods: This is a cross sectional prospective observational study with 150 cancer patients requiring analgesics and was conducted at the oncology ward of a tertiary care hospital. The prescription pattern, the mitigation of pain and the adverse events were recorded. Results: The results indicate that morphine injection was the most effective followed by morphine tablets, ultracet, tramadol and paracetamol. With regard to the adverse effects it was observed that 70.7% of the patients had one or other symptoms and that constipation (9.3%; 14/150) followed by nausea (8%; 12/150) and drowsiness (5.3%; 8/150) were the most common. Conclusion:The results of the study indicate that in spite of administering protective/ preventive drugs analgesic-induced adverse effects are common in cancer patients.

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Section: Discussionsupporting

confidence: 52%

Audit of Efficacy and Adverse Events of Analgesics Used to Mitigating Cancer Pain: Observations From a Tertiary Care Hospital

Simon¹,

Palatty²,

Thilakchand³

et al. 2018

IJMLR

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“…[ 430 ] Further, a fixed-dose combination of tramadol/paracetamol might be a useful pharmacological option for chronic pain management, particularly in elderly patients. [ 431 ] Neuropathic pain can be severe and can impact quality of life, limit mobility, and contribute to depression and social dysfunction. [ 432 ] Management of underlying depression is a must to improve QoL.…”

Section: R Ationale and E Videncementioning

confidence: 99%

“…[ 430 ] Further, a fixed-dose combination of tramadol/paracetamol might be a useful pharmacological option for chronic pain management, particularly in elderly patients. [ 431 ]…”

Section: R Ationale and E Videncementioning

confidence: 99%

RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 2020

Chawla

Madhu

Makkar

et al. 2020

Indian J Endocr Metab

110

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“…This use is reflected by tramadol being included in a number of national and international guidelines, 45 – 47 and is in line with its role in therapy as described in the international literature. 25 , 48 , 49 …”

Section: Discussionmentioning

confidence: 99%

Tramadol: a valuable treatment for pain in Southeast Asian countries

Vijayan¹,

Afshan²,

Bashir³

et al. 2018

JPR

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BackgroundThe supply of controlled drugs is limited in the Far East, despite the prevalence of health disorders that warrant their prescription. Reasons for this include strict regulatory frameworks, limited financial resources, lack of appropriate training amongst the medical profession and fear of addiction in both general practitioners and the wider population. Consequently, the weak opioid tramadol has become the analgesic most frequently used in the region to treat moderate to severe pain.MethodsTo obtain a clearer picture of the current role and clinical use of tramadol in Southeast Asia, pain specialists from 7 countries in the region were invited to participate in a survey, using a questionnaire to gather information about their individual use and experience of this analgesic.ResultsFifteen completed questionnaires were returned and the responses analyzed. Tramadol is used to manage acute and chronic pain caused by a wide range of conditions. Almost all the specialists treat moderate cancer pain with tramadol, and every one considers it to be significant or highly significant in the treatment of moderate to severe non-cancer pain. The reasons for choosing tramadol include efficacy, safety and tolerability, ready availability, reasonable cost, multiple formulations and patient compliance. Its safety profile makes tramadol particularly appropriate for use in elderly patients, outpatients, and for long-term treatment. The respondents strongly agreed that tighter regulation of tramadol would reduce its medical availability and adversely affect the quality of pain management. In some countries, there would no longer be any appropriate medication for cancer pain or the long-term treatment of chronic pain.ConclusionsIn Southeast Asia, tramadol plays an important part in the pharmacological management of moderate to severe pain, and may be the only available treatment option. If it were to become a controlled substance, the standard of pain management in the region would decline.

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Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review

Cited by 10 publications

References 95 publications

Audit of Efficacy and Adverse Events of Analgesics Used to Mitigating Cancer Pain: Observations From a Tertiary Care Hospital

Audit of Efficacy and Adverse Events of Analgesics Used to Mitigating Cancer Pain: Observations From a Tertiary Care Hospital

RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 2020

Tramadol: a valuable treatment for pain in Southeast Asian countries

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