Trametes robiniophila Murr in the treatment of breast cancer

Li, Chen; Wang, Xiaolong; Chen, Tong; Wang, Wei; Yang, Qifeng

doi:10.1016/j.biopha.2020.110254

Cited by 15 publications

(12 citation statements)

References 134 publications

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“…Conventional therapies for cancer include surgery, radiotherapy, chemotherapy, endocrine therapy, and targeted therapy [ 3 , 4 ]. However, currently available therapies have serious limitations, including severe side effects and dose-limiting toxicities [ 5 ]. The common adverse effect of cancer treatments includes nausea, vomiting, peripheral neuropathy, pain, and insomnia, which reduce the quality of life [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Dietary Antioxidants in p53‐Mediated Cancer Chemoprevention and Tumor Suppression

Merlin

Rupasinghe

Dellaire

et al. 2021

Oxidative Medicine and Cellular Longevity

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Cancer arises through a complex interplay between genetic, behavioral, metabolic, and environmental factors that combined trigger cellular changes that over time promote malignancy. In terms of cancer prevention, behavioral interventions such as diet can promote genetic programs that may facilitate tumor suppression; and one of the key tumor suppressors responsible for initiating such programs is p53. The p53 protein is activated by various cellular events such as DNA damage, hypoxia, heat shock, and overexpression of oncogenes. Due to its role in cell fate decisions after DNA damage, regulatory pathways controlled by p53 help to maintain genome stability and thus “guard the genome” against mutations that cause cancer. Dietary intake of flavonoids, a C15 group of polyphenols, is known to inhibit cancer progression and assist DNA repair through p53-mediated mechanisms in human cells via their antioxidant activities. For example, quercetin arrests human cervical cancer cell growth by blocking the G2/M phase cell cycle and inducing mitochondrial apoptosis through a p53-dependent mechanism. Other polyphenols such as resveratrol upregulate p53 expression in several cancer cell lines by promoting p53 stability, which in colon cancer cells results in the activation of p53-mediated apoptosis. Finally, among vitamins, folic acid seems to play an important role in the chemoprevention of gastric carcinogenesis by enhancing gastric epithelial apoptosis in patients with premalignant lesions by significantly increased expression of p53. In this review, we discuss the role of these and other dietary antioxidants in p53-mediated cell signaling in relation to cancer chemoprevention and tumor suppression in normal and cancer cells.

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Section: Introductionmentioning

confidence: 99%

Role of Dietary Antioxidants in p53‐Mediated Cancer Chemoprevention and Tumor Suppression

Merlin

Rupasinghe

Dellaire

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Aqueous extraction of Huaier was kindly provided by Gaitianli Medicine Co. Ltd (Jiangsu, China). Preparations of Huaier were described in our previous study ( Li C. et al, 2020 ). To yield the active ingredient, the dried fungus of Huaier was extracted by hot water in triplicate after grinding.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Trametes robiniophila Murr (Huaier) was a sandy beige mushroom which belonged to Class Hymenomycetes, Phylum Basidiomycota ( Li C. et al, 2020 ). Being used as a medicinal ingredient in China for approximately 1,600 years, Huaier had been revealed to play a vital role in several types of cancers ( Li C. et al, 2020 ). A nationwide multicenter clinical trial indicated that combined use of Huaier granule as adjuvant therapy could obviously prolong the recurrence-free survival in hepatocellular carcinoma patients ( Chen et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2α Signaling Pathway in Triple Negative Breast Cancer

Wang

Chen

et al. 2022

Front. Cell Dev. Biol.

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Triple-negative breast cancer (TNBC) is the most lethal breast cancer subtype owing to the lack of targeted therapeutic strategies. Immunogenic cell death (ICD), a modality of regulated cancer cell death, offered a novel option for TNBC via augmenting tumor immunogenic microenvironment. However, few ICD-inducing agents are currently available. Here, we showed that Trametes robiniophila Murr (Huaier) triggered ICD in TNBC cells by promoting cell surface calreticulin (CRT) exposure, and increasing release of adenosine triphosphate (ATP) and high-mobility group protein B1 (HMGB1). Co-culturing with Huaier-treated TNBC cells efficiently enhanced the maturation of dendritic cells (DCs), which was further validated via cell-based vaccination assay. In the xenograft mouse model, oral administration of Huaier led to tumor-infiltrating lymphocytes (TILs) accumulation and significantly delayed tumor growth. Besides, depletion of endogenous T cells obviously abrogated the effect. Mechanically, Huaier could elicit endoplasmic reticulum (ER) stress-associated ICD through eIF2α signaling pathway. Further studies revealed that circCLASP1 was involved in the Huaier-induced immunogenicity by binding with PKR in the cytoplasm and thus blocking its degradation. Taken together, we highlighted an essential role of circCLASP1/PKR/eIF2α axis in Huaier-induced ICD. The findings of our study carried significant translational potential that Huaier might serve as a promising option to achieve long-term tumor remission in patients with TNBC.

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“…Recently, the using of Huaier granules combined with chemotherapy for treating GC has attracted increasing worldwide interest. [ 22 – 24 ] Although several epidemiologic studies were performed for its efficiency with gastric cancer, no consensus conclusion has been reached yet. [ 19 ] The efficacy and safety of Huaier granules combined with chemotherapy in the treatment for GC remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Huaier granules combined with chemotherapy for gastric cancer

Hou

Xiong

2020

Medicine

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Background: Huaier granules, the aqueous product of Huaier ( Trametes robiniophila Murr. ) extract, are a broad-spectrum anti-tumor drug and have been widely used for the treatment of gastric cancer (GC). The aim of this study is to systematically investigate the efficacy and safety of Huaier granules combined with chemotherapy in the treatment of GC. Methods: Three English databases and four Chinese databases will be searched from its inception to July 2020. Two methodological trained researchers will select the qualified studies for data extraction independently. Cochrane Risk of Bias tool will be used to assess the risk of bias of included studies. The RevMan 5.2 and stata 14.0 software will be applied for statistical analyses. Statistical heterogeneity will be computed by Cochrane X 2 and I 2 tests. Sensitivity analysis will be conducted to evaluate the stability of the results. The publication bias will be evaluated by funnel plots and Egger's test. The quality of evidence will be assessed by the GRADE system. Results: The results of our research will be published in a peer-reviewed journal. Conclusion: The conclusion of our systematic review will provide evidence to judge whether Huaier granules combined with chemotherapy is an effective intervention for patient with GC. OSF registration number: 10.17605/OSF.IO/9BVJD.

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Trametes robiniophila Murr in the treatment of breast cancer

Cited by 15 publications

References 134 publications

Role of Dietary Antioxidants in p53‐Mediated Cancer Chemoprevention and Tumor Suppression

Role of Dietary Antioxidants in p53‐Mediated Cancer Chemoprevention and Tumor Suppression

Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2α Signaling Pathway in Triple Negative Breast Cancer

Efficacy and safety of Huaier granules combined with chemotherapy for gastric cancer

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