TRAMIL ethnomedicinal survey in Jamaica

Picking, David; Delgoda, Rupika; Younger, Novie; Germosén-Robineau, Lionel; Boulogne, Isabelle; Mitchell, Sylvia

doi:10.1016/j.jep.2015.04.027

Cited by 33 publications

(16 citation statements)

References 58 publications

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“…Collected leaf and stem plant material was bench-dried in our laboratory and then finely crushed using a coffee grinder. The ground plant material was prepared as an infusion following traditional Jamaican practices [ 17 , 19 ] using 100 mL of boiled deionized water per 1 g of dried plant material and infused for fifteen to twenty minutes. The resulting liquor was suction filtered through type 1 Whatman filter paper and centrifuged (MSE Micro Centaur, Sanyo, Osaka, Japan) at 13,000 g for five minutes to remove suspended solids.…”

Section: Methodsmentioning

confidence: 99%

“…CYP1 inhibitions and associated antioxidant activities have also been linked with chemopreventive potential and thus we also carried out an in vitro antioxidant screen [ 8 ]. H. verticillata was previously identified as one of the top 25 medicinal plants used by Jamaicans in a TRAMIL survey [ 3 , 17 ]. TRAMIL, a Caribbean-wide applied research programme, scientifically evaluates and documents the efficacy and safety of medicinal plant remedies used for primary healthcare [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions

et al. 2018

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Understanding the potential for adverse drug reactions (ADRs), from herb-drug interactions, is a key aspect of medicinal plant safety, with particular relevance for public health in countries where medicinal plant use is highly prevalent. We undertook an in-depth assessment of extracts of Hyptis verticillata Jacq., via its impact on activities of key cytochrome P450 (CYP) enzymes (CYPs 1A1, 1A2, 1B1, 3A4 and 2D6), its antioxidant properties (determined by DPPH assays) and chemical characterisation (using LC-MS). The dried plant aqueous extract demonstrated potent inhibition of the activities of CYPs 1A1 (7.6 µg/mL), 1A2 (1.9 µg/mL), 1B1 (9.4 µg/mL) and 3A4 (6.8 µg/mL). Further analysis of other crude extracts demonstrated potent inhibition of CYP1A2 activity for a dried plant ethanol extract (1.5 µg/mL), fresh plant ethanol extract (3.9 µg/mL), and moderate activity for a fresh plant aqueous extract (27.8 µg/mL). All four extracts demonstrated strong antioxidant activity, compared to the positive control (ascorbic acid, 1.3 µg/mL), with the dried plant ethanol extract being the most potent (1.6 µg/mL). Analysis of the dried plant aqueous extract confirmed the identity of seven phytochemicals, five lignans and two triterpenes. Individual screening of these phytochemicals against the activity of CYP1A2 identified yatein as a moderate inhibitor (71.9 μM), likely to contribute to the plant extract’s potent bioactivity. Further analysis on the impact of this plant on key drug metabolizing enzymes in vivo appears warranted for likely ADRs, as well as furthering development as a potential chemopreventive agent.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions

et al. 2018

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“…These books describe Caribbean medicinal plants and their folk uses, some are illustrated, and most have been published in the last 20 years (all since 1986 and 76% (16/21) since 2001). Twelve new literature sources have since been added [12,[55][56][57][58][59][60][61][62][63][64][65]. This database (Version2) now includes 3566 plants growing in the Caribbean that have been identified with at least one ethnomedicinal use-some as tonics, some preventative, some curative-for health and wellness purposes (Figure 8).…”

Section: Caribbean Medicinal Plantsmentioning

confidence: 99%

“…A 1929 publication listed 41 medicinal plants [72]. Asprey 2015 listed 116 plants of which 107 had herbarium vouchers and 8 were endemic [63].…”

Section: Case Study: Jamaica and Trinidad Medicinal Plantsmentioning

confidence: 99%

“…Without illustrations, how are we sure what plant they were referring to? This is important for while the author of this 1929 paper [72] thought 'such use of plants represents a rapidly passing phase of human healing' , a 2008 ethnobotanical survey [63,89] indicates that this practice is still being used.…”

Section: Case Study: Identification Of Jamaican Medicinal Endemicsmentioning

confidence: 99%

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Valuing Caribbean Biodiversity Knowledge

Mitchell¹,

Kitson-Walters²,

Mitchell³

2020

Changing Ecosystems and Their Services

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Valuing Caribbean biodiversity for health and wealth requires knowledge of the bioresource so as to better appreciate the myriad of uses and services it provides. Increasing the knowledge base provides increasingly accurate valuation, which hopefully will lead to better management and sustainable use of this biodiversity. The Caribbean region comprises 229,540 km 2 of land (only 10% of which is still in original forest cover) and 2,754,000 km 2 of ocean. In the region there are about 13,000 identified plant species of which 205 genera and 6500 species are endemic. The marine area, with a maximum depth of 7686 m, includes the world's second largest barrier reef. It is estimated that the region has 25.6% marine endemic species. Multiple uses have been found for both terrestrial and marine organisms of the Caribbean. Mass extinctions have occurred for Peoples, associated traditional knowledge, terrestrial and marine biodiversity. Sea level rise and increasing temperature are global problems that threaten this area. All this information cannot be covered in one chapter so this review, based on a wide range of publications including our own research, is to raise awareness of these issues and the need to know more while suggesting solutions for discussion.

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Introduction

Vandebroek¹,

Picking²

2020

Advances in Economic Botany

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TRAMIL ethnomedicinal survey in Jamaica

Cited by 33 publications

References 58 publications

Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions

Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions

Valuing Caribbean Biodiversity Knowledge

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