Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial

Xu, Jianjun; Gao, Wei; Ju, Yingnan

doi:10.1007/s00404-012-2593-y

Cited by 120 publications

(156 citation statements)

References 17 publications

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“…Its efficacy, in reducing blood loss and transfusion requirements, in both these settings has been confirmed. [60][61][62] For speed and simplicity we use a For personal use only. on April 29, 2019.…”

Section: Tranexamic Acidmentioning

confidence: 99%

How I treat postpartum hemorrhage

Pavord

Maybury

2015

Blood

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Worldwide, ∼800 women die every day from preventable causes related to pregnancy or childbirth. The single most common cause is severe bleeding, which can kill a healthy woman within hours if care is substandard or delayed. Improved antenatal practices have led to the early identification of at-risk women and modern technology and new techniques have enabled effective management strategies so that now, in the western world, most of the morbidity and mortality arises from those cases which occur unexpectedly and could not have been predicted. Prompt and effective management and multidisciplinary involvement is paramount to save the lives of these women. We use a case report to illustrate and discuss the main elements of management of this condition.

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Section: Tranexamic Acidmentioning

confidence: 99%

How I treat postpartum hemorrhage

Pavord

Maybury

2015

Blood

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“…The blood loss from the end of CS to 2 hours post delivery of 42.75±40.45 ml in the TXA group versus 73.98±77.09 ml in the control group (P=0.001) was also comparable [20] . The blood loss in the two periods was also significantly reduced in the TXA group according to Xu J et al [21] and Mayur G et al [22] .…”

Section: Discussionmentioning

confidence: 88%

Effect of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section

Rushulo¹

2016

jmscr

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“…Xu et al [33] tried intravenous injection of 10 mg/kg TXA immediately before CS and found blood loss in the period between the end of CS and 2 h postpartum was significantly lower in the TXA group than in the control group and PP hemorrhage stopped in 75.6 % of controls and in 92% in TXA group with significant difference in favor of TXA.…”

Section: Discussionmentioning

confidence: 99%

Role of Incisional infiltration with intraperitoneal instillation analgesia in non descent vaginal hysterectomy

Assar

Elmentawy

Mosaad

et al. 2018

Evidence Based Women's Health Journal

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Objective: To evaluate therapeutic yield of tranexamic acid (TXA) injection and fluid co-load on the outcome of cesarean section (CS) conducted under spinal anesthesia Study Design : Prospective randomized comparative study. Patients and Methods:The current included 174 primipara scheduled for elective CS under spinal anesthesia. Intravenous (IV) fluid co-load (15 ml/kg warm lactated ringer solution) started as fast drip during and continued after spinal anesthesia. Patients were randomly allocated into two equal groups: Group TXA received a loading IV dose of 500 mg TXA 20 minutes before surgery followed by continuous TXA infusion at rate of 1 mg/kg/min till end of surgery. Group C did not receive prophylactic TXA, but both groups received a booster dose of 2 gm TXA if required. Patients were monitored for the frequency and severity of hypotension and dose of ephedrine used. Amount of bleeding since skin incision till 2-hours postpartum (PP), the frequency of patients had stopped PP bleeding till 2-hr PP and the total dose of oxytocin drugs and booster doses of TXA were recorded. Results: Hypotension was recorded in 53 patients (30.5%); only 12 patients had blood pressure <80 mmHg. The lowest blood pressure, frequency of hypotension, time of occurrence and duration of hypotension and the used dose of ephedrine showed non-significant difference between both studied groups. The amount of perioperative bleeding was significantly lower in TXA group compared to control group. Twenty parturient had continued PP bleeding for more than 2 hours PP with significantly (p=0.038) lower frequency of bleeders in TXA group. All women had continued bleeding received booster doses of TXA with a significantly higher dose in control group compared to TXA group. Conclusion: Preoperative administration of TXA significantly reduced perioperative bleeding with significant reduction of consumption of TXA booster doses and utrotonics without affecting safety. Fluid coloading allowed reduction of the frequency and extent of hypotension concomitant with spinal anesthesia.

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Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial

Abstract: Treatment with TXA is effective in reducing blood loss in patients undergoing CS. Although the study was not adequately powered to address safety issues, the observed side effects were mild and transient.

Cited by 120 publications

References 17 publications

How I treat postpartum hemorrhage

How I treat postpartum hemorrhage

Effect of Intravenous Administration of Tranexamic Acid in Reducing Blood Loss During and After Caesarean Section

Role of Incisional infiltration with intraperitoneal instillation analgesia in non descent vaginal hysterectomy

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