Tranexamic acid in adenotonsillectomy in children: A double-blind randomized clinical trial

Brum, Marília Ribeiro; Miura, M.; Castro, Samantha Fernandez de; Machado, Graziella Moraes; Lima, Lucélia Hernandes; Neto, José Faibes Lubianca

doi:10.1016/j.ijporl.2012.04.028

Cited by 23 publications

(25 citation statements)

References 13 publications

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“…[8], [9]. In recent studies, systemic infusion of anti-fibrinlytic drugs have been used to reduce bleeding in various forms of surgery such as major orthopedic surgery, adeno-tonsillectomy, and endoscopic sinus surgery [7], [10]–[12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Topical Tranexamic Acid on Bleeding and Quality of Surgical Field during Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis: A Triple Blind Randomized Clinical Trial

et al. 2014

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BackgroundThe effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during functional endoscopic sinus surgery (FESS) is not clear yet. This study was conducted to answer this question.MethodsThis trial was conducted on 60 patients with chronic sinusitis at Beasat Hospital, Hamadan, Iran, from April to November 2013. Thirty patients in the intervention group received three pledgets soaked with TXA 5% and phenylephrine 0.5% for 10 minutes in each nasal cavity before surgery. Thirty patients in the control group received phenylephrine 0.5% with the same way. The amount of bleeding and the quality of surgical field were evaluated at 15, 30, and 45 minutes after the start of surgery using Boezaart grading.ResultsThe quality of the surgical field in the intervention group compared to the control group was significantly better in the first quarter (P = 0.002) and the second quarter (P = 0.003) but not in the third quarter (P = 0.163). Furthermore, the amount of bleeding was much less during all periods in the intervention group than in the control group (P = 0.001).ConclusionTopical TXA can efficiently reduce bleeding and improve the surgical field in FESS in patients with rhinosinusitis. Based on these findings, topical TXA may be a useful method for providing a suitable surgical field during the first 30 minutes after use.Trial RegistrationIranian Registry of Clinical Trials IRCT201212139014N15

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Section: Introductionmentioning

confidence: 99%

Effect of Topical Tranexamic Acid on Bleeding and Quality of Surgical Field during Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis: A Triple Blind Randomized Clinical Trial

et al. 2014

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“…Most notable is a 2014 review of 872,416 patients undergoing either a total hip or total knee replacement, which found that IV TXA significantly reduced the need for blood transfusion and intensive care admissions. Three RCTs showed benefit in endoscopic sinus surgery and one in adenotonsillectomy. A smaller trial ( n = 28) found no benefit in FESS, and a trial in head and neck surgery ( n = 35) found no benefit in reducing postoperative drain output.…”

Section: Discussionmentioning

confidence: 96%

Tranexamic acid in epistaxis: a systematic review

Kamhieh

Fox

2016

Clinical Otolaryngology

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“…The laboratory investigation included for all 23 (100%) the patients was CBC, BT, CT, PT and APTT kept up by Ryczer T, Randall DA and Brum MR et al study [20] [28] [29].…”

Section: Discussionmentioning

confidence: 99%

Spongstan with Nasopharyngeal Pack: New Ordinary Procedure Manage the Adenoidectomy Bleeding

Ahm¹

2020

GJMR

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Objective: To find out the frequency, prevalence, and epidemiological aspects of the adenoidectomy bleeding and share the new ordinary procedure to manage it by spongstan with the nasopharyngeal pack. Study Design: Cohort retrospective study. Setting: Academic tertiary care hospitals. Subject and Methods: A total of 23 adenoidectomy children’s demographic data collection and analyzed who suffered from complications of bleeding in the department of Otolaryngology and Head-Neck Surgery, Comilla Medical College Hospital, and Comilla Medical Centre, concerned Clinic of Central Medical College from 01 July 2016 to 31 June 2019. Results: Incidence of adenoidectomy bleeding among total operative patients was 0.32%, adenoidectomy-Tonsillectomy patients 2.66%, and the yearly prevalence of 33.35%. Off them, the male was 09 (39.17%), and the female 14 (60.87%), 11-15 years children have highest bleeding complications was 17 (73.91%), commonest presenting features was nasal obstruction (91.30%), mouth breathing (82.61%), and hearing loss (78.26%).

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Tranexamic acid in adenotonsillectomy in children: A double-blind randomized clinical trial

Cited by 23 publications

References 13 publications

Effect of Topical Tranexamic Acid on Bleeding and Quality of Surgical Field during Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis: A Triple Blind Randomized Clinical Trial

Effect of Topical Tranexamic Acid on Bleeding and Quality of Surgical Field during Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis: A Triple Blind Randomized Clinical Trial

Tranexamic acid in epistaxis: a systematic review

Spongstan with Nasopharyngeal Pack: New Ordinary Procedure Manage the Adenoidectomy Bleeding

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