Tranexamic acid‐loaded hemostatic nanoclay microsphere frameworks

Denry, Isabelle; Nédélec, Jean-Marie; Holloway, Julie A.

doi:10.1002/jbm.b.34918

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The results of the nitrogen sorption analysis 58 are also presented in this section and summarized in Figure 3. The synthesized MCM‐41 nanoparticles had a specific surface area, pore volume and pore diameter of 1123.335 m 2 g −1 , 1.701 m 3 g −1 , and 2.342 nm, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…From Figure 2B, the percentage weight loss due to decomposition of the nanoparticles; MCM-41, MCM-N, MCM-B, and MCM-B-D were determined to be $15%, 20%, 27.5%, and 30%, respectively. These The results of the nitrogen sorption analysis 58 are also presented in this section and summarized in Figure 3. The synthesized MCM-41 nanoparticles had a specific surface area, pore volume and pore diameter of 1123.335 m 2 g À1 , 1.701 m 3 g À1 , and 2.342 nm, respectively.…”

Section: Physicochemical Properties Of the Silica Nanoparticlesmentioning

confidence: 89%

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Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition

et al. 2022

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This article presents silica nanoparticles for the sustained release of AMACR antibody-conjugated and free doxorubicin (DOX) for the inhibition of prostate cancer cell growth. Inorganic MCM-41 silica nanoparticles were synthesized, functionalized with phenylboronic acid groups (MCM-B), and capped with dextran (MCM-B-D). The nanoparticles were then characterized using Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, zeta potential analysis, nitrogen sorption, X-ray diffraction, and thermogravimetric analysis, before exploring their potential for drug loading and controlled drug release. This was done using a model prostate cancer drug, DOX, and a targeted prostate cancer drug, α-Methyl Acyl-CoA racemase (AMACR) antibody-conjugated DOX, which attaches specifically to AMACR proteins that are overexpressed on the surfaces of prostate cancer cells. The kinetics of sustained drug release over 30 days was then studied using zeroth order, first order, second order, Higuchi, and the Korsmeyer-Peppas models, while the thermodynamics of drug release was elucidated by determining the entropy and enthalpy changes. The flux of the released DOX was also simulated using the COMSOL Multiphysics software package. Generally, the AMACR antibodyconjugated DOX drug-loaded nanoparticles were more effective than the free DOX drug-loaded formulations in inhibiting the growth of prostate cancer cells in vitro over a 96 h period. The implications of the results are then discussed for the development of drug-eluting structures for the localized and targeted treatment of prostate cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Physicochemical Properties Of the Silica Nanoparticlesmentioning

confidence: 89%

Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition

et al. 2022

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“…[ 45 ] The combination of hemostatic (Ca 2+ ) and antifibrinolytic (TXA‐NH 2 ) properties is efficient to stop hemorrhage. [ 46 ] These results indicated that all these factors contributed to the excellent pro‐coagulation performance of the J‐CMH@CaCO 3 /T.…”

Section: Resultsmentioning

confidence: 91%

Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control

Zhao

et al. 2022

Advanced Science

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Uncontrolled hemorrhage is a major cause of potentially preventable death in civilian trauma nowadays. Considerable concern has been given to the development of efficient hemostats with high blood absorption, self‐propelled property, and Ca2+ release ability, for irregularly shaped and noncompressible hemorrhage. Herein, Janus self‐propelled chitosan‐based hydrogel with CaCO3 (J‐CMH@CaCO3) is developed by partial ionic crosslinking of carboxylated chitosan (CCS) and Ca2+, gravity settlement, and photopolymerization, followed by removing the shell of CCS. The obtained J‐CMH@CaCO3 is further used as a hemostat powered by the internal CaCO3 and coordinated protonated tranexamic acid (J‐CMH@CaCO3/T). Bubbles are generated and detached to provide the driving force, accompanied by the release of Ca2+. The two aspects work in synergy to accelerate clot formation, endowing the J‐CMH@CaCO3/T with excellent hemostatic efficiency. The J‐CMH@CaCO3/T presents high blood absorption, favorable blood‐clotting ability, desired erythrocyte and platelet aggregation, and acceptable hemocompatibility and cytocompatibility. In rodent and rabbit bleeding models, the J‐CMH@CaCO3/T exhibits the most effective hemostasis to the best knowledge of the authors, wherein the hemorrhage is rapidly halted within 39 s. It is believed that the J‐CMH@CaCO3/T with self‐propelled property opens up a new avenue to design high‐performance hemostats for clinical application.

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Novel Honeycomb Nanoclay Frameworks With Hemostatic and Antibacterial Properties

Cambronel,

Wongkamhaeng,

Blavignac

et al. 2024

J Biomed Mater Res

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Our laboratory recently developed a new class of high surface area, honeycomb Nanoclay Microsphere Framework absorbents (NMFs) that prompt rapid hemostasis. In the present work, we propose a novel approach to develop antibacterial Topical Hemostatic Agents (THAs) by anchoring silver nanoparticles (AgNPs) onto NMFs. This combination was obtained by a chemical co‐reduction approach, followed by freeze‐processing, and was shown to ensure stability and on‐site delivery of AgNPs, without altering the hemostatic properties of NMFs. Silver‐loaded NMFs showed no change in their unique architecture and led to a 55% increase in clot strength, compared to standard control plasma or commercially available THA, and a significant decrease in mean fibrin fiber diameter. Silver nanoparticles were successfully released when solubilized and prevented the growth of both Pseudomonas aeruginosa and Staphylococcus aureus at concentrations of 22 and 30 ppm of silver released, respectively. Overall, cell mortality was between 9.1 ± 5.1% and 6.3 ± 3.2%, depending on AgNP concentration, confirming a low cytotoxicity. Silver‐loaded nanoclay microsphere frameworks appear to constitute promising candidates as topical hemostatic agents for secondary management of hemostasis when infection control is needed.

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Tranexamic acid‐loaded hemostatic nanoclay microsphere frameworks

Cited by 5 publications

References 35 publications

Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition

Sustained release of alpha‐methylacyl‐CoA racemase (AMACR) antibody‐conjugated and free doxorubicin from silica nanoparticles for prostate cancer cell growth inhibition

Janus Self‐Propelled Chitosan‐Based Hydrogel Spheres for Rapid Bleeding Control

Novel Honeycomb Nanoclay Frameworks With Hemostatic and Antibacterial Properties

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