Tranexamic Acid Reduces Intraoperative Blood Loss in Pediatric Patients Undergoing Scoliosis Surgery

Sethna, Navil F.; Zurakowski, David; Brustowicz, Robert M.; Bacsik, Julianne; Sullivan, Lorna J.; Shapiro, Frederic

doi:10.1097/00000542-200504000-00006

Cited by 279 publications

(225 citation statements)

References 22 publications

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“…The results of those few studies have been positive, but inconsistent. In a study of patients undergoing posterior spinal fusion for scoliosis, Sethna et al [27] revealed a 41 % decrease in intraoperative blood loss after the administration of TXA. No difference was found in the amount of blood transfused.…”

Section: Discussionmentioning

confidence: 99%

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

Lykissas

Crawford

Chan

et al. 2013

Journal of Children's Orthopaedics

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Purpose Intraoperative blood loss in scoliosis surgery often requires transfusions. Autogenous blood decreases but does not eliminate risks typically associated with allogenic blood transfusion. Costs associated with transfusions are significant. Tranexamic acid (TXA) has been shown to decrease blood loss in cardiac and joint surgery. Few studies have examined its use in pediatric spine surgery, and the results are inconsistent. The aim of this study was to determine whether TXA decreases intraoperative blood loss and transfusion requirements in adolescent idiopathic scoliosis patients undergoing posterior spinal fusion by a single surgeon. Methods The medical records and operative reports of surgically treated patients with adolescent idiopathic scoliosis between 2000 and 2009 were retrospectively reviewed. The inclusion criteria were: (1) patients who underwent instrumented posterior spinal fusion, (2) had complete medical records, and (3) were treated by the same surgeon. Forty-nine patients who met the inclusion criteria were divided into two groups: Group A (25 patients) received TXA, while Group B (24 patients) did not receive TXA.Results After controlling for age at the time of surgery, gender, and number of vertebral levels fused, the mean intraoperative blood loss was significantly lower in Group A (537 ml) than in Group B (1,245 ml) (p = 0.027). The mean volume of blood transfused intraoperatively was 426 and 740 ml for Group A and Group B, respectively. The difference was not statistically significant after controlling for age, gender, and number of levels fused (p = 0.078). Conclusion TXA significantly decreased intraoperative blood loss in posterior spinal fusions performed for adolescent idiopathic scoliosis.

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Section: Discussionmentioning

confidence: 99%

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

Lykissas

Crawford

Chan

et al. 2013

Journal of Children's Orthopaedics

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“…In this study, although PBL and TBL were significantly reduced in the tranexamic acid group, IBL was comparable between the two groups. Previous studies reported lower IBL in tranexamic acid-infused patients [18][19][20]. Tranexamic acid was infused following an initial pre-operative loading dose in the other studies, while we gave 10 mg.kg À1 of tranexamic acid with HES administration during the main surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

The effect of tranexamic acid on blood coagulation in total hip replacement arthroplasty: rotational thromboelastographic (ROTEM^®) analysis

Shin

Lee

et al. 2015

Anaesthesia

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SummaryWe evaluated changes in rotational thromboelastometry (ROTEM â ) parameters and clinical outcomes in patients undergoing total hip replacement arthroplasty, with concomitant infusions of tranexamic acid and of 6% hydroxyethyl starch 130/0.4. Fifty-five patients were randomly assigned to either the tranexamic acid (n = 29) or the control (n = 26) group. Hydroxyethyl starch was administered in the range of 10-15 ml.kg À1 during the operation in both groups. In the control group, the clot formation time and maximum clot firmness of APTEM showed significant differences when compared with those of EXTEM at one hour postoperatively, suggestive of fibrinolysis. In the tranexamic acid group, there was no significant difference between each postoperative EXTEM and APTEM parameter. In the tranexamic acid and control group, postoperative blood loss was 308 ml (210-420 [106-745]) and 488 ml (375-620 [170-910], p = 0.002), respectively, and total blood loss was

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“…Another study showed the safety of TXA use in scoliosis surgery upon postoperative examination detecting no clinical evidence of deep venous thrombosis 17 . Subsequent to these two studies, numerous other studies support its perioperative safety as shown in the studies included in our meta-analysis (Table 6).…”

Section: Discussion:-mentioning

confidence: 99%

Efficacy of Tranexamic Acid in Reducing Blood Loss and Blood Transfusion in Idiopathic Scoliosis; A Systematic Review and Meta-Analysis.

Ajmi¹,

Saeed²,

Faryan³

et al. 2017

IJAR

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Tranexamic Acid Reduces Intraoperative Blood Loss in Pediatric Patients Undergoing Scoliosis Surgery

Abstract: Intraoperative administration of tranexamic acid significantly reduces blood loss during spinal surgery in children with scoliosis.

Cited by 279 publications

References 22 publications

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

The effect of tranexamic acid on blood coagulation in total hip replacement arthroplasty: rotational thromboelastographic (ROTEM^®) analysis

Efficacy of Tranexamic Acid in Reducing Blood Loss and Blood Transfusion in Idiopathic Scoliosis; A Systematic Review and Meta-Analysis.

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Tranexamic Acid Reduces Intraoperative Blood Loss in Pediatric Patients Undergoing Scoliosis Surgery

Abstract: Intraoperative administration of tranexamic acid significantly reduces blood loss during spinal surgery in children with scoliosis.

Cited by 279 publications

References 22 publications

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

The effect of tranexamic acid in blood loss and transfusion volume in adolescent idiopathic scoliosis surgery: A single-surgeon experience

The effect of tranexamic acid on blood coagulation in total hip replacement arthroplasty: rotational thromboelastographic (ROTEM®) analysis

Efficacy of Tranexamic Acid in Reducing Blood Loss and Blood Transfusion in Idiopathic Scoliosis; A Systematic Review and Meta-Analysis.

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The effect of tranexamic acid on blood coagulation in total hip replacement arthroplasty: rotational thromboelastographic (ROTEM^®) analysis