Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial

Ifunanya, Nwafor Johnbosco; Chukwu, Ibo Chukwunenye; Nobert, Obi Chuka; Blessing, Onwe; Chibuzor, Ugoji Darlington-Peter; Uchenna, Onuchukwu Victor Jude

doi:10.4236/ojog.2019.96089

Cited by 15 publications

(16 citation statements)

References 14 publications

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“…In the present study mean age was 24.25±4.02 years in TXA group and 24.23±4.14 years in control group (p=0.945, NS). Our study was found to be comparable with the studies reported by Elhamid et al and Ifunanya et al [9,10] .…”

Section: Discussionsupporting

confidence: 93%

“…Previous history of postpartum haemorrhage was observed in 12(2.4%) and 15(3%) women of TXA and control group respectively (p >0.05). These findings found to be comparable with the study reported by Ifunanya et al [10] .…”

Section: Discussionsupporting

confidence: 93%

“…Mean gestational age at labour was 38.60±1.28 weeks in TXA group and 38.62±1.25 weeks in control group (p>0.05, NS). The results of the present study was almost similar to studies reported by Elhamid et al and Ifunanya et al [9,10] . In TXA group, 294 (58.8%) and in control group, 280 (56%) patients were nulliparous in the present study, similar to study reported by Ducloy-Bouthors et al [11] .…”

Section: Discussionsupporting

confidence: 93%

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Efficacy and safety of tranexamic acid in the prevention of postpartum haemorrhage after vaginal delivery

Dahiya¹,

Shalu²

2021

Int. J. Clin. Obstet. Gynaecol.

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Introduction: Postpartum haemorrhage is one of the leading causes of death in women who deliver after 20 weeks of gestation. The prevalence of PPH in India is 23%. Delayed diagnosis and poor management of PPH are associated with increased morbidity and mortality. Material and Methods: This prospective randomised controlled study was conducted on one thousand women at period of gestation ≥37 weeks for vaginal delivery. Aim and Objectives: To evaluate the role of tranexamic acid in decreasing blood loss after normal vaginal delivery. Results: Majority of women belonged to 21-25 years age group in both the group. Blood loss at 3 rd stage of labour in TXA group was 376.12±63.82 ml and in control group it was 654.08±86.61 ml. The mean haemoglobin reduction (pre-post) suggested that tranexamic acid group (0.44±4.3) had a significantly less haemoglobin drop as compared to control group (1.850±0.58). There was significant less fall in mean haemoglobin percentage (3.86% versus 16.15%) and mean haematocrit percentage (3.80% versus 12.72%) in TXA group as compared to control group. Forty four (8.8%) women in TXA group and seventy eight women (15.6%) in control group had postpartum haemorrhage. Twenty one (4.2%) women received blood transfusion in TXA group and forty four (8.8%) women in control group. Forty four women had PPH and out of which, 33 (6.6%) were managed medically and in 11 (2.2%) women, balloon tamponade was used along with additional uterotonics for control of PPH. In control group, a total of 78 (15.6%) women had PPH and 55 (11%) were managed by medically and 23(4.6%) by balloon tamponade along with additional uterotonics for control of PPH. The most common side effect was nausea/vomiting observed in both the groups. Conclusion: Tranexamic acid was found to be safe and effective in reducing blood loss after normal vaginal delivery. There was less drop in haemoglobin and haematocrit in tranexamic acid group which reduced the risk of blood transfusion and additional uterotonics.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

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Efficacy and safety of tranexamic acid in the prevention of postpartum haemorrhage after vaginal delivery

Dahiya¹,

Shalu²

2021

Int. J. Clin. Obstet. Gynaecol.

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“…This value is similar to the 30.8%, 34.0%, and 30.0% reduction in blood loss reported by Umeora et al [22] in Abakaliki, Maged et al [23] in Cairo, Egypt and Ahmed [24] in Ismaila, Egypt respectively. However, Ifunanya et al [25] from Abakaliki reported a slightly higher reduction in blood loss (45.0%) attributable to preoperative administration of Tranexamic acid. These differences in blood loss may be because of the different time intervals used in assessing the blood loss and the different methods used in the estimation of blood loss in the various studies.…”

Section: Discussionmentioning

confidence: 92%

"The Efficacy of Prophylactic Tranexamic Acid in Reducing Perioperative Blood Loss During Caesarean Section: A Randomized, Double Blind Control Trial"

Km¹

2021

JGWH

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“…However, it only leads to maternal mortality in about 6.4% of cases while other conditions of obstetric hemorrhage such as the ruptured uterus, placenta praveia, abruption, cervical and vaginal trauma, inverted uterus, and adherent placenta mostly result in maternal death. 8 , 9 Currently, various measures including administration of uterotonics, prostaglandins, and active management of 3 rd stage of labor are used to prevent PPH. According to Cochrane review, through active management of labor the incidence of PPH> 1000 ml has been significantly reduced.…”

Section: Introductionmentioning

confidence: 99%

Intravenous Tranexamic acid versus placebo during Caesarian section: A comparative study

Iqbal¹,

Mazhar²,

Shabir³

2022

Pak J Med Sci

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Objectives: To evaluate the effectiveness of Tranexamic Acid in preventing postpartum hemorrhage against placebo in high-risk women undergoing cesarean section. Methods: A double-blinded placebo-controlled comparative trial was conducted at the Obstetrics and Gynecology Department of Nishtar Hospital for one year, from 15th June 2020 to 15th June 2021. A total of 60 women who were at high risk of postpartum hemorrhage and had to undergo elective cesarean sections were included in the study. Among them, initial 30 patients were administered Tranexamic Acid before skin incision whereas later 30 were treated as the placebo group. These women were then observed for blood loss during surgery and within 24 hrs. after surgery and any postoperative complications such as thromboembolic events, the need for additional uterotonic agents, and blood transfusions. Results: Out of 60 women, 30 were placed in each group. The groups had no significant difference in terms of baseline data and post-partum hemorrhage-associated risk factors (p>0.05). However, the occurrence rate of primary post-partum hemorrhage (blood loss greater than 1000 ml) was significantly less in a tranexamic acid group than the placebo group (16.6% vs 60%, respectively, p<0.01). Similarly, the requirement of additional uterotonic agents (13.3% vs 43.3%, respectively) and the need for blood transfusion (6.0% vs 23.3%, respectively) was lower in a tranexamic group than in the placebo group. Conclusion: The study highlighted the significance of tranexamic acid in controlling post-partum hemorrhages, the requirement of additional uterotonic agents, improving post-partum hemoglobin, and the need for blood transfusion. doi: https://doi.org/10.12669/pjms.38.5.5383 How to cite this:Iqbal MJ, Mazhar A, Shabir A. Intravenous Tranexamic acid versus placebo during Caesarian section: A comparative study. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5383 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial

Cited by 15 publications

References 14 publications

Efficacy and safety of tranexamic acid in the prevention of postpartum haemorrhage after vaginal delivery

Efficacy and safety of tranexamic acid in the prevention of postpartum haemorrhage after vaginal delivery

"The Efficacy of Prophylactic Tranexamic Acid in Reducing Perioperative Blood Loss During Caesarean Section: A Randomized, Double Blind Control Trial"

Intravenous Tranexamic acid versus placebo during Caesarian section: A comparative study

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