Trans‐Generational Epigenetic Inheritance

Harper, Lawrence V.

doi:10.1002/9781444327632.ch14

Cited by 3 publications

References 183 publications

(197 reference statements)

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Biology, Development, and Human Systems

Lickliter

Honeycutt

2015

Handbook of Child Psychology and Developmental Science

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Biology has genetic, epigenetic, developmental, ecological, and evolutionary components. In addition to the scientific fields contributing to biology the philosophy of science also frames the field. As is the case with all the sciences, progress in biology depends on advances in theory building, empirical research, and modeling. Development, as one of the central processes of biology, has been the focus of both empirical and theoretical attention for centuries. Research techniques and methods used in biology to study development have evolved dramatically over the past several decades, generating a wealth of detailed empirical data. Metatheoretical frameworks, theories, and modeling have likewise advanced, calling into question established interpretations and assumptions about development, including the relation between genotype and phenotype, the nature and extent of heredity, the links between development and evolution, and the biological bases of behavior and cognition. In this chapter, we review the history and current status of biology's view of development and discuss the broader implications of this view for a psychobiological systems view of human development.

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Biology, Development, and Human Systems

Lickliter

Honeycutt

2015

Handbook of Child Psychology and Developmental Science

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Molecular Genetics and Human Behavior

Partridge

2012

Encyclopedia of Human Behavior

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Parental methylation mediates how progeny respond to environments of parents and of progeny themselves

Morgan

Donohue

2022

Annals of Botany

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Background and Aims Environments experienced by both parents and offspring influence progeny traits, but the epigenetic mechanisms that regulate the balance of parental versus progeny control of progeny phenotypes are not known. We tested whether DNA methylation in parents and/or progeny mediates responses to environmental cues experienced in both generations. Methods Using Arabidopsis thaliana, we manipulated parental and progeny DNA methylation both chemically, via 5-azacytidine, and genetically, via mutants of methyltransferase genes, then measured progeny germination responses to simulated canopy shade in parental and progeny generations. Key Results We first found that germination of offspring responded to parental but not seed demethylation. We further found that parental demethylation reversed the parental effect of canopy in seeds with low (Cvi-1) to intermediate (Col) dormancy, but it obliterated the parental effect in seeds with high dormancy (Cvi-0). Demethylation did so by either suppressing germination of seeds matured under white-light (Cvi-1) or canopy (Cvi-0), or by increasing germination of seeds matured under canopy (Col). Disruption of parental methylation also prevented seeds from responding to their own light environment in one genotype (Cvi-0, most dormant), but it enabled seeds to respond to their own environment in another genotype (Cvi-1, least dormant). Using mutant genotypes, we found that both CG and non-CG DNA methylation were involved in parental effects on seed germination. Conclusions In summary, parental methylation state influences seed germination more strongly than does the progeny’s own methylation state, and it influences how seeds respond to environments of parents and progeny in a genotype-specific manner.

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Trans‐Generational Epigenetic Inheritance

Cited by 3 publications

References 183 publications

Biology, Development, and Human Systems

Biology, Development, and Human Systems

Molecular Genetics and Human Behavior

Parental methylation mediates how progeny respond to environments of parents and of progeny themselves

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