Trans-generational immune priming in honeybees

López, Javier Hernández; Schuehly, Wolfgang; Crailsheim, Karl; Riessberger-Gallé, Ulrike

doi:10.1098/rspb.2014.0454

Cited by 101 publications

(81 citation statements)

References 43 publications

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“…2010), woodlice (Roth & Kurtz 2009), and fruit flies (Pham et al . 2007), as well as trans-generationally primed honeybees (Hernández López et al . 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there is conflicting evidence as to the protective mechanism of priming once these eggs hatch and the larvae develop, with some studies showing a continued concentration of antimicrobial peptides (Barribeau et al . 2016; Sadd & Schmid-Hempel 2007), some suggesting a differentiated cellular response (Hernández López et al . 2014), and some implicating an inducible transcriptional program (Trauer-Kizilelma & Hilker 2015).…”

Section: Introductionmentioning

confidence: 99%

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The within‐host dynamics of infection in trans‐generationally primed flour beetles

et al. 2017

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Many taxa exhibit plastic immune responses initiated after primary microbial exposure that provide increased protection against disease-induced mortality and the fitness costs of infection. In several arthropod species, this protection can even be passed from parents to offspring through a phenomenon called trans-generational immune priming. Here, we first demonstrate that trans-generational priming is a repeatable phenomenon in flour beetles (Tribolium castaneum) primed and infected with Bacillus thuringiensis (Bt). We then quantify the within-host dynamics of microbes and host physiological responses in infected offspring from primed and unprimed mothers by monitoring bacterial density and using mRNA-seq to profile host gene expression, respectively, over the acute infection period. We find that priming increases inducible resistance against Bt around a critical temporal juncture where host septicemic trajectories, and consequently survival, may be determined in unprimed individuals. Our results identify a highly differentially expressed biomarker of priming, containing an EIF4-e domain, in uninfected individuals, as well as several other candidate genes. Moreover, the induction and decay dynamics of gene expression over time suggest a metabolic shift in primed individuals. The identified bacterial and gene expression dynamics are likely to influence patterns of bacterial fitness and disease transmission in natural populations.

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“…2010), woodlice (Roth & Kurtz 2009), and fruit flies (Pham et al . 2007), as well as trans-generationally primed honeybees (Hernández López et al . 2014).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The within‐host dynamics of infection in trans‐generationally primed flour beetles

et al. 2017

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“…Our analyses showed that while the results obtained from TER studies are largely consistent with our theoretical predictions, the signal is much less clear for TEI studies. We believe that an integrative view of the transgenerational immune memory requires both approaches [17,18,21,62,63].…”

Section: Discussionmentioning

confidence: 99%

Evolution of transgenerational immunity in invertebrates

et al. 2016

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Over a decade ago, the discovery of transgenerational immunity in invertebrates shifted existing paradigms on the lack of sophistication of their immune system. Nonetheless, the prevalence of this trait and the ecological factors driving its evolution in invertebrates remain poorly understood. Here, we develop a theoretical host -parasite model and predict that long lifespan and low dispersal should promote the evolution of transgenerational immunity. We also predict that in species that produce both philopatric and dispersing individuals, it may pay to have a plastic allocation strategy with a higher transgenerational immunity investment in philopatric offspring because they are more likely to encounter locally adapted pathogens. We review all experimental studies published to date, comprising 21 invertebrate species in nine different orders, and we show that, as expected, longevity and dispersal correlate with the transfer of immunity to offspring. The validity of our prediction regarding the plasticity of investment in transgenerational immunity remains to be tested in invertebrates, but also in vertebrate species. We discuss the implications of our work for the study of the evolution of immunity, and we suggest further avenues of research to expand our knowledge of the impact of transgenerational immune protection in host -parasite interactions.

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“…Sadd et al, 2005;Moret, 2006;Sadd and Schmid-Hempel, 2007;Roth et al, 2010;Hernández López et al, 2014). Although these studies remove the effect of pathogen multiplication and possible vertical transmission, injection is an unnatural exposure route and it is not clear how relevant these studies are to actual pathogen infection.…”

Section: Introductionmentioning

confidence: 95%