Trans-meningeal drug delivery to optic nerve ganglion cell axons using a nanoparticle drug delivery system

Grove, Karen; Dobish, Julia N.; Harth, Eva; Ingram, Michael; Galloway, Robert L.; Mawn, Louise A.

doi:10.1016/j.exer.2013.10.016

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…A successful case of intranasal administration of fluorescent QDs encapsulated in neural stem cells, in which the QD‐labeled stem cells passed through the epithelium and then through the sieve plate into the CNS, with clear fluorescence being observed (Galeano et al, 2018), demonstrate the feasibility of delivering QDs via the intranasal route of administration. In addition, there are also through the trigeminal nerve (Li et al, 2019), optic nerve (Grove et al, 2014), and auditory nerve (Schmidt et al, 2018) pathway for delivering NPs to the brain; it is reasonable to infer that the possibility of QDs also exists to transit through the above pathway.…”

Section: The Penetrability Of Qds To Bbbmentioning

confidence: 99%

Exposure of quantum dots in the nervous system: Central nervous system risks and the blood–brain barrier interface

Guan,

Tang

2023

J of Applied Toxicology

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Quantum dots currently possess significant importance in the field of biomedical science. Upon introduction into the body, quantum dots exhibit a tendency to accumulate in diverse tissues including the central nervous system (CNS). Consequently, it becomes imperative to devote specific attention to their potential toxic effects. Moreover, the preservation of optimal CNS function relies heavily on blood–brain barrier (BBB) integrity, thereby necessitating its prioritization in neurotoxicological investigations. A more comprehensive understanding of the BBB and CNS characteristics, along with the underlying mechanisms that may contribute to neurotoxicity, will greatly aid researchers in the development of effective design strategies. This article offers an in‐depth look at the methods used to reduce the harmful effects of quantum dots on the nervous system, alongside the progression of effective treatments for brain‐related conditions. The focal point of this discussion is the BBB and its intricate association with the CNS and neurotoxicology. The discourse commences by recent advancements in the medical application of quantum dots are examined. Subsequently, elucidating the mechanisms through which quantum dots infiltrate the human body and traverse into the brain. Additionally, the discourse delves into the factors that facilitate the passage of quantum dots across the BBB, primarily encompassing the physicochemical properties of quantum dots and the BBB's inherent capacity for self‐permeability alteration. Furthermore, a concluding summary is presented, emphasizing existing research deficiencies and identifying promising avenues for further investigation within this field.

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