trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro

Guschlbauer, Maria; Klinger, Stefanie; Burmester, Marion; Horn, Jana; Kulling, Sabine E.; Breves, Gerhard

doi:10.1016/j.cbpa.2013.03.040

Cited by 34 publications

(24 citation statements)

References 41 publications

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“…3b, RSV decreased the glucose-induced ΔI sc (p = 0.002), what is already known from our previous studies [22, 25]. Additionally, this part of the study may give some new indications that RSV may affect Ca 2+ -induced Cl − secretion since the glucose-induced I sc for ctrl/Cl − -free chambers was decreased compared to ctrl/Cl − chambers (p = 0.014).…”

Section: Resultssupporting

confidence: 74%

“…After an equilibration period with chloride-containing or chloride-free buffer solutions, RSV (Sigma-Aldrich, 300 µM) or ethanol (control, 20 µl/10 ml) were added to the mucosal compartment. After 30 min, glucose (10 mM mucosal) was applied in order to induce Na + -coupled glucose transport which is known to be inhibited by RSV [22, 25]. After another 10 min, carbachol (10 µM serosal, Sigma-Aldrich) was added to stimulate Ca 2+ -induced Cl − secretion (ΔI sc carbachol 1) [3].…”

Section: Methodsmentioning

confidence: 99%

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Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue

2018

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ObjectiveChloride (Cl−) secretion is crucial for intestinal fluid secretion. Therefore, effects of the polyphenol Resveratrol (RSV) on Cl− secretion have been investigated. In a previous study, we observed effects of RSV on forskolin-induced Cl− secretion in the porcine jejunum but not the ileum although RSV itself induced a transepithelial ion current that may represent Cl− secretion in the ileum. The aim of this study was to gain further insights regarding the effects of RSV on characteristics of Cl− secretion in the porcine ileum using the Ussing chamber technique (recording of short circuit currents (Isc) as a measure for epithelial net ion transfer).ResultsRSV increased the Isc in the porcine ileum but not in the porcine jejunum as is already known. This increase was absent in a Cl−-free buffer system, indicating that RSV indeed induces Cl− secretion. However, the carbachol-induced Isc was significantly inhibited by RSV indicating an inhibition of Ca2+-induced Cl− secretion. The cellular basis for these contradictory, segment specific results of RSV on Cl− secretion has to be subjected to further studies. The results also underline, that is difficult to generalize effects of RSV between different intestinal locations, organs, cell culture models or species.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3825-4) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 74%

Section: Methodsmentioning

confidence: 99%

Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue

2018

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“…The biological activities of piceid have not been thoroughly studied, but it seems it may also have beneficial effects on health (Chong et al, 2009). ε-Viniferin has promising actions in vitro, like decreasing glucose absorption (Guschlbauer et al, 2013) and inhibiting vascular muscle cell proliferation (Zghonda et al, 2011) and amyloid-beta peptide aggregation (Rivière et al, 2010). Resveratrol and its derivatives are naturally produced by plants as self-defence agents either in response to biotic or abiotic stress or constitutively without elicitors (Jeandet et al, 2010), and thus can be considered as phytoalexins and phytoanticipins.…”

Section: Introductionmentioning

confidence: 99%

Stilbenes in the different organs of Vitis vinifera cv. Merlot grafted on Teleki Kober 5BB rootstock

et al. 2017

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Aim: To determine which of the grapevine organ is the richest in stilbene, like the t-piceid, t-resveratrol and ε-viniferin and would it be useful as by-product of viticulture for processing stilbene concentrate.Methods and results: Nine organs, such as cane, buds, shoot tips, inflorescences, clusters at veraison, matured berry skins, seeds and cluster stems, of Merlot grafted on Teleki Kober 5BB rootstock were collected during a year and its ethanolic extractions were analyzed via HPLC-FLD. Stilbene content of the different organs occurred in a wide range, the lowest was 3.15 mg/kg dry weight (dw) measured in the seeds and the highest 2265 mg/kg dw in the buds.Conclusion: The present research demonstrated that different grapevine organs contain different amount of stilbene in the vineyard. The winter-buds, the roots and the matured cane internodes of Merlot are significantly richer in t-resveratrol and t-ε-viniferin than the green vegetative and generative parts we examined in one growing year. Significance and impact of the study: According to our knowledge there was no stilbenes measuring in several plant organs of a vine cultivar in field study, in vineyard. Our research pointed out the pruned cane could be primary source of stilbene of the health-industry. Beside that grape root is a by-product of grapevine nursery is also rich in stilbene.

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“…All features of this transcriptional signature were found in PBMCs of the HATFF study. Other effects increasing OGIS may be increased pancreatic b-cell sensitivity to glucose (42), decreased intestinal absorption of glucose (43), changes of gut microbiota, and decreased breakdown and absorption of starch (44) (Fig. 5).…”

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Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

et al. 2016

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Risk of insulin resistance, impaired glycemic control, and cardiovascular disease is excessive in overweight and obese populations. We hypothesized that increasing expression of glyoxalase 1 (Glo1)-an enzyme that catalyzes the metabolism of reactive metabolite and glycating agent methylglyoxal-may improve metabolic and vascular health. Dietary bioactive compounds were screened for Glo1 inducer activity in a functional reporter assay, hits were confirmed in cell culture, and an optimized Glo1 inducer formulation was evaluated in a randomized, placebo-controlled crossover clinical trial in 29 overweight and obese subjects. We found trans-resveratrol (tRES) and hesperetin (HESP), at concentrations achieved clinically, synergized to increase Glo1 expression. In highly overweight subjects (BMI >27.5 kg/m 2 ), tRES-HESP coformulation increased expression and activity of Glo1 (27%, P < 0.05) and decreased plasma methylglyoxal (237%, P < 0.05) and total body methylglyoxal-protein glycation (214%, P < 0.01). It decreased fasting and postprandial plasma glucose (25%, P < 0.01, and 28%, P < 0.03, respectively), increased oral glucose insulin sensitivity index (42 mL $ min 21 $ m 22, P < 0.02), and improved arterial dilatation Dbrachial artery flowmediated dilatation/Ddilation response to glyceryl nitrate (95% CI 0.13-2.11). In all subjects, it decreased vascular inflammation marker soluble intercellular adhesion molecule-1 (210%, P < 0.01). In previous clinical evaluations, tRES and HESP individually were ineffective. tRES-HESP coformulation could be a suitable treatment for improved metabolic and vascular health in overweight and obese populations.

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trans-Resveratrol and ε-viniferin decrease glucose absorption in porcine jejunum and ileum in vitro

Cited by 34 publications

References 41 publications

Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue

Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue

Stilbenes in the different organs of <em>Vitis vinifera</em> cv. Merlot grafted on Teleki Kober 5BB rootstock

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

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