Trans-resveratrol micronization by SEDS technique

Aguiar, Gean Pablo S.; Boschetto, Daiane L.; Chaves, Lorenzo M.P.C.; Arcari, Bianca D.; Piato, Ângelo; Oliveira, J. Vladimir; Lanza, Marcelo

doi:10.1016/j.indcrop.2016.04.047

Cited by 32 publications

(22 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, when observing the particle size in relation to processing temperature, it can be concluded that the higher the temperature, the bigger the particle size for all assays at the same concentration and pressure, varying the temperature from 308 to 313 K (1 and 2), (4 and 5) and (6 and 7). This behavior was also observed by Aguiar et al (2016) in trans-resveratrol micronization by SEDS technique.…”

Section: Resultssupporting

confidence: 74%

“…Obtaining micro and nanoparticles can be performed by many conventional encapsulation techniques such as spray drying, freeze drying, solute recrystallization and interfacial polymerization. However, these techniques demonstrate serious drawbacks, like excessive use of solvent, heat degradation of solute, chemical changes, and difficulty in controlling the particle size (Priamo et al 2011;Aguiar et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, several researchers have demonstrated that supercritical fluids, especially supercritical carbon dioxide, are useful as anti-solvents to modify material properties such as particle size, size distribution and morphology. The application of supercritical fluids shows interesting advantages like the possibility of eliminating or reducing the use of organic solvents, the efficient separation of the solvent and anti-solvent of the particles after precipitation, hence allowing obtaining solvent-free products (Franceschi et al 2008a(Franceschi et al , 2009Priamo et al 2011;Boschetto et al 2013;Machado Jr et al 2016;Aguiar et al 2016). Besides, the use of supercritical carbon dioxide as an anti-solvent in the SEDS technique allows working at near-ambient temperature, avoiding degradation of thermosensitive compounds (Cocero et al 2009).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Encapsulation of eugenyl acetate in PHBV using SEDS technique and in vitro release evaluation

Loss

Pereira²,

Boschetto³

et al. 2016

J Food Sci Technol

Self Cite

View full text Add to dashboard Cite

Eugenyl acetate obtained via enzymatic esterification using Lipozyme TL IM enzyme was encapsulated in biopolymer poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) through solution-enhanced dispersion by supercritical fluids (SEDS). Produced particles were characterized by SEM and confocal microscopy techniques and in addition in vitro release assays were performed in isopropanol and ethyl acetate. Experimental micronization conditions comprised 8 and 10 MPa, 308 and 313 K and eugenyl acetate concentration ranging from 5 to 20 mg mL, keeping PHBV concentration constant (20 mg mL in dichloromethane). The maximum encapsulation efficiency was 58.0 % for 5 mg mLof eugenyl acetate at 8 MPa and 308 K. The morphology of the encapsulated particles for most of the trials was spherical, with particle size ranging from 0.061 to 0.276 μm. Regarding the release in ethyl acetate and isopropanol solvents the higher the affinity of the encapsulated ester of these solvents, the faster the release was observed. These results demonstrate the importance of essential clove oil esterification reaction and encapsulation of the ester by SEDS method so that this encapsulated ester can be used in different industrial applications.

show abstract

Section: Resultssupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Encapsulation of eugenyl acetate in PHBV using SEDS technique and in vitro release evaluation

Loss

Pereira²,

Boschetto³

et al. 2016

J Food Sci Technol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides, micronization of resveratrol can be another approach to increase its bioavailability. By reducing the particle size of pharmaceutical compounds, their physical structures are greatly modified such that better solubility, permeability, and eventually bioavailability can be achieved (Aguiar et al, ). Optimization of drug delivery of resveratrol may resolve the lack of consistency between preclinical and clinical findings.…”

Section: Conflicting Effects Of Resveratrolmentioning

confidence: 99%

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Cheng

Luo

Lau

et al. 2019

British J Pharmacology

113

View full text Add to dashboard Cite

Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

show abstract

“…Further, its benefits are affected after its oral administration owing to its poor solubility and instability in physiological conditions as well as extensive metabolism [8,9]. To date, several formulation strategies such as amorphous solid dispersions, composite nanoparticles, emulsions, liposomes, polymeric micelles, self-emulsifying drug delivery systems, and solid lipid nanoparticles have been investigated to resolve this problem [10][11][12][13][14][15][16][17][18][19]. In addition, the enhanced oral bioavailability in humans has been reported with lipid formulation, micellar liquid formulation, and microparticles mixed with a liquid formulation [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Pure Trans-Resveratrol Nanoparticles Prepared by a Supercritical Antisolvent Process Using Alcohol and Dichloromethane Mixtures: Effect of Particle Size on Dissolution and Bioavailability in Rats

Park

Lee

et al. 2020

Antioxidants

View full text Add to dashboard Cite

The aim of this study was to prepare pure trans-resveratrol nanoparticles without additives (surfactants, polymers, and sugars) using a supercritical antisolvent (SAS) process with alcohol (methanol or ethanol) and dichloromethane mixtures. In addition, in order to investigate the effect of particle size on the dissolution and oral bioavailability of the trans-resveratrol, two microparticles with different sizes (1.94 µm and 18.75 µm) were prepared using two different milling processes, and compared to trans-resveratrol nanoparticles prepared by the SAS process. The solid-state properties of pure trans-resveratrol particles were characterized. By increasing the percentage of dichloromethane in the solvent mixtures, the mean particle size of trans-resveratrol was decreased, whereas its specific surface area was increased. The particle size could thus be controlled by solvent composition. Trans-resveratrol nanoparticle with a mean particle size of 0.17 µm was prepared by the SAS process using the ethanol/dichloromethane mixture at a ratio of 25/75 (w/w). The in vitro dissolution rate of trans-resveratrol in fasted state-simulated gastric fluid was significantly improved by the reduction of particle size, resulting in enhanced oral bioavailability in rats. The absolute bioavailability of trans-resveratrol nanoparticles was 25.2%. The maximum plasma concentration values were well correlated with the in vitro dissolution rate. These findings clearly indicate that the oral bioavailability of trans-resveratrol can be enhanced by preparing pure trans-resveratrol nanoparticles without additives (surfactants, polymers, and sugars) by the SAS process. These pure trans-resveratrol nanoparticles can be applied as an active ingredient for the development of health supplements, pharmaceutical products, and cosmetic products.

show abstract

Trans-resveratrol micronization by SEDS technique

Cited by 32 publications

References 21 publications

Encapsulation of eugenyl acetate in PHBV using SEDS technique and in vitro release evaluation

Encapsulation of eugenyl acetate in PHBV using SEDS technique and in vitro release evaluation

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Pure Trans-Resveratrol Nanoparticles Prepared by a Supercritical Antisolvent Process Using Alcohol and Dichloromethane Mixtures: Effect of Particle Size on Dissolution and Bioavailability in Rats

Contact Info

Product

Resources

About