Objective. To analyze the effect of early predictive nursing on complications and quality of life in patients after colorectal cancer surgery. Methods. A total of 130 patients with colorectal cancer who were diagnosed and underwent surgical resection in our hospital from 2019 to 2021 were recruited and assigned via the random number table method (1 : 1) to receive either conventional nursing (routine group) or predictive nursing (study group). Outcome measures included the incidence of complications and the quality of life. Results. Predictive nursing was associated with shorter operation time and hospital stay and less blood loss (2.35 ± 0.41, 9.32 ± 1.86, and 70.52 ± 16.52) versus conventional nursing (3.02 ± 0.78, 11.20 ± 2.14, and 81.51 ± 17.74) (all
P
<
0.05
). Patients in the study group showed a lower incidence of complications than the control group (10.76% vs 35.38%) (all
P
<
0.05
). Predictive nursing resulted in better anxiety relief than conventional nursing (
P
<
0.05
). Predictive nursing was associated with higher emotional function, cognitive function, role function, and physical function scores (83.51 ± 12.56, 82.45 ± 9.15, 82.48 ± 10.46, 84.43 ± 13.48, and 82.73 ± 9.67) than conventional nursing (73.85 ± 13.54, 72.54 ± 12.74, 72.48 ± 10.45, 73.99 ± 14.51, and 72.45 ± 11.69) (all
P
<
0.05
). Patients receiving predictive nursing showed a significantly higher nursing satisfaction versus conventional nursing (
P
<
0.05
). Conclusion. Early predictive nursing for patients receiving colorectal cancer surgery can lower the incidence of complications, effectively improve the quality of life of patients, shorten the hospital stay, reduce the amount of bleeding, and enhance the satisfaction of patients.